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Items: 1 to 20 of 572

1.

Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Aβ pathology and improves cognitive function.

Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL.

Exp Mol Med. 2012 Dec 31;44(12):740-8. doi: 10.3858/emm.2012.44.12.082.

2.

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

Saura CA, Chen G, Malkani S, Choi SY, Takahashi RH, Zhang D, Gouras GK, Kirkwood A, Morris RG, Shen J.

J Neurosci. 2005 Jul 20;25(29):6755-64.

3.

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.

Zhang W, Hao J, Liu R, Zhang Z, Lei G, Su C, Miao J, Li Z.

Behav Brain Res. 2011 Sep 23;222(2):342-50. doi: 10.1016/j.bbr.2011.03.072. Epub 2011 Apr 14.

PMID:
21513747
4.

Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.

Aso E, Lomoio S, López-González I, Joda L, Carmona M, Fernández-Yagüe N, Moreno J, Juvés S, Pujol A, Pamplona R, Portero-Otin M, Martín V, Díaz M, Ferrer I.

Brain Pathol. 2012 Sep;22(5):636-53. doi: 10.1111/j.1750-3639.2011.00560.x. Epub 2012 Jan 13.

PMID:
22188425
5.

The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.

Collins JM, King AE, Woodhouse A, Kirkcaldie MT, Vickers JC.

Exp Neurol. 2015 May;267:219-29. doi: 10.1016/j.expneurol.2015.02.034. Epub 2015 Mar 4.

PMID:
25747037
6.

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.

Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T.

J Neurosci. 2016 Mar 30;36(13):3848-59. doi: 10.1523/JNEUROSCI.3757-15.2016.

7.
8.

Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice.

Liu MY, Wang S, Yao WF, Zhang ZJ, Zhong X, Sha L, He M, Zheng ZH, Wei MJ.

Neuroscience. 2014 Jul 25;273:141-51. doi: 10.1016/j.neuroscience.2014.05.011. Epub 2014 May 15.

PMID:
24846616
9.

Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease.

Lok K, Zhao H, Zhang C, He N, Shen H, Wang Z, Zhao W, Yin M.

J Neurol Sci. 2013 Dec 15;335(1-2):145-54. doi: 10.1016/j.jns.2013.09.018. Epub 2013 Sep 21.

PMID:
24095271
10.

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro.

Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R, Liu P.

Neurosci Lett. 2009 Mar 13;452(2):90-5. doi: 10.1016/j.neulet.2009.01.013. Epub 2009 Jan 13.

PMID:
19154776
11.

Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice.

Laursen B, Mørk A, Plath N, Kristiansen U, Bastlund JF.

Behav Brain Res. 2013 Mar 1;240:146-52. doi: 10.1016/j.bbr.2012.11.012. Epub 2012 Nov 22.

PMID:
23178660
12.

Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice.

Li X, Guo F, Zhang Q, Huo T, Liu L, Wei H, Xiong L, Wang Q.

BMC Complement Altern Med. 2014 Jan 22;14:37. doi: 10.1186/1472-6882-14-37.

13.

Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease.

Lewis TL, Cao D, Lu H, Mans RA, Su YR, Jungbauer L, Linton MF, Fazio S, LaDu MJ, Li L.

J Biol Chem. 2010 Nov 19;285(47):36958-68. doi: 10.1074/jbc.M110.127829. Epub 2010 Sep 16.

14.

Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice.

Zhao G, Liu HL, Zhang H, Tong XJ.

Neuroscience. 2015 Jul 9;298:357-66. doi: 10.1016/j.neuroscience.2015.04.038. Epub 2015 Apr 23.

PMID:
25917310
15.

The Ames dwarf mutation attenuates Alzheimer's disease phenotype of APP/PS1 mice.

Puig KL, Kulas JA, Franklin W, Rakoczy SG, Taglialatela G, Brown-Borg HM, Combs CK.

Neurobiol Aging. 2016 Apr;40:22-40. doi: 10.1016/j.neurobiolaging.2015.12.021. Epub 2016 Jan 6.

16.

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

Paris D, Ganey NJ, Laporte V, Patel NS, Beaulieu-Abdelahad D, Bachmeier C, March A, Ait-Ghezala G, Mullan MJ.

J Neuroinflammation. 2010 Mar 8;7:17. doi: 10.1186/1742-2094-7-17.

17.
18.

Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model.

Park TS, Ryu YK, Park HY, Kim JY, Go J, Noh JR, Kim YH, Hwang JH, Choi DH, Oh WK, Lee CH, Kim KS.

Int J Mol Med. 2017 Jan;39(1):21-30. doi: 10.3892/ijmm.2016.2804. Epub 2016 Nov 16.

19.

By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice.

Yu X, Guan PP, Guo JW, Wang Y, Cao LL, Xu GB, Konstantopoulos K, Wang ZY, Wang P.

FASEB J. 2015 Dec;29(12):5044-58. doi: 10.1096/fj.15-275578. Epub 2015 Aug 20.

20.

Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both Aβ and Tau pathologies.

Li C, Guo XD, Lei M, Wu JY, Jin JZ, Shi XF, Zhu ZY, Rukachaisirikul V, Hu LH, Wen TQ, Shen X.

Acta Pharmacol Sin. 2017 Jan;38(1):9-28. doi: 10.1038/aps.2016.94. Epub 2016 Oct 3.

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