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Complement factor C5a and C5a receptor contribute to morphine tolerance and withdrawal-induced hyperalgesia in rats.

Li YH, Jin H, Xu JS, Guo GQ, Chen DL, Bo Y.

Exp Ther Med. 2012 Oct;4(4):723-727. Epub 2012 Jul 10.


Lipoxin A4 analog attenuates morphine antinociceptive tolerance, withdrawal-induced hyperalgesia, and glial reaction and cytokine expression in the spinal cord of rat.

Jin H, Li YH, Xu JS, Guo GQ, Chen DL, Bo Y.

Neuroscience. 2012 Apr 19;208:1-10. doi: 10.1016/j.neuroscience.2012.02.009. Epub 2012 Feb 14.


Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat.

Niu Z, Ma J, Chu H, Zhao Y, Feng W, Cheng Y.

Neurosci Lett. 2012 Nov 7;529(2):112-7. doi: 10.1016/j.neulet.2012.09.034. Epub 2012 Sep 27.


Melatonin prevents morphine-induced hyperalgesia and tolerance in rats: role of protein kinase C and N-methyl-D-aspartate receptors.

Song L, Wu C, Zuo Y.

BMC Anesthesiol. 2015 Jan 28;15:12. doi: 10.1186/1471-2253-15-12. eCollection 2015.


Increased local concentration of complement C5a contributes to incisional pain in mice.

Jang JH, Liang D, Kido K, Sun Y, Clark DJ, Brennan TJ.

J Neuroinflammation. 2011 Jul 7;8:80. doi: 10.1186/1742-2094-8-80.


Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.

Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F.

Pain. 2007 May;129(1-2):35-45. Epub 2006 Nov 22.


Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat.

Dunbar SA, Karamian I, Zhang J.

Eur J Pain. 2007 Jan;11(1):1-6. Epub 2006 Jan 30.


Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance.

Little JW, Cuzzocrea S, Bryant L, Esposito E, Doyle T, Rausaria S, Neumann WL, Salvemini D.

Pain. 2013 Jul;154(7):978-86. doi: 10.1016/j.pain.2013.02.018. Epub 2013 Feb 27.


A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.

Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR.

J Neurosci. 2004 Aug 18;24(33):7353-65.


Low-Dose Cannabinoid Type 2 Receptor Agonist Attenuates Tolerance to Repeated Morphine Administration via Regulating μ-Opioid Receptor Expression in Walker 256 Tumor-Bearing Rats.

Zhang M, Wang K, Ma M, Tian S, Wei N, Wang G.

Anesth Analg. 2016 Apr;122(4):1031-7. doi: 10.1213/ANE.0000000000001129.


Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway.

Chen Y, Geis C, Sommer C.

J Neurosci. 2008 May 28;28(22):5836-45. doi: 10.1523/JNEUROSCI.4170-07.2008.


Central administration of selective melanocortin 4 receptor antagonist HS014 prevents morphine tolerance and withdrawal hyperalgesia.

Kalange AS, Kokare DM, Singru PS, Upadhya MA, Chopde CT, Subhedar NK.

Brain Res. 2007 Nov 21;1181:10-20. Epub 2007 Sep 4.


The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.

Shutov LP, Warwick CA, Shi X, Gnanasekaran A, Shepherd AJ, Mohapatra DP, Woodruff TM, Clark JD, Usachev YM.

J Neurosci. 2016 May 4;36(18):5055-70. doi: 10.1523/JNEUROSCI.3249-15.2016.


Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: implications for opioid hyperalgesia and tolerance.

Zhao YL, Chen SR, Chen H, Pan HL.

J Biol Chem. 2012 Jul 20;287(30):25073-85. doi: 10.1074/jbc.M112.378737. Epub 2012 Jun 7.


Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance.

Xie JY, Herman DS, Stiller CO, Gardell LR, Ossipov MH, Lai J, Porreca F, Vanderah TW.

J Neurosci. 2005 Jan 12;25(2):409-16.

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