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Items: 1 to 20 of 58


GPRC5B activates obesity-associated inflammatory signaling in adipocytes.

Kim YJ, Sano T, Nabetani T, Asano Y, Hirabayashi Y.

Sci Signal. 2012 Nov 20;5(251):ra85. doi: 10.1126/scisignal.2003149.


Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.

Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2008 Aug;57(8):2149-57. doi: 10.2337/db08-0176. Epub 2008 Apr 28.


Effect of NF-κB decoy on insulin resistance of adipocytes from patients with type 2 diabetes mellitus.

Zhong L, Luo Y, Huang C, Liu L.

Diabetes Metab. 2011 Dec;37(6):520-6. doi: 10.1016/j.diabet.2011.04.004. Epub 2011 Jun 12.


Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans.

Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, Satoh-Asahara N, Shimoda Y, Tanaka M, Kim-Saijo M, Miyamoto Y, Kamei Y, Sata M, Ogawa Y.

Diabetes. 2011 Mar;60(3):819-26. doi: 10.2337/db10-0864. Epub 2011 Jan 31.


SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells.

McPherson VA, Sharma N, Everingham S, Smith J, Zhu HH, Feng GS, Craig AW.

J Immunol. 2009 Oct 15;183(8):4940-7. doi: 10.4049/jimmunol.0900702. Epub 2009 Sep 28.


Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.

Hinoi E, Iezaki T, Ozaki K, Yoneda Y.

Biochem Biophys Res Commun. 2014 Oct 3;452(4):974-9. doi: 10.1016/j.bbrc.2014.09.022. Epub 2014 Sep 16.


Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinase.

Yamada E, Bastie CC.

PLoS One. 2014 Feb 25;9(2):e89604. doi: 10.1371/journal.pone.0089604. eCollection 2014.


Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production.

Lin L, Pang W, Chen K, Wang F, Gengler J, Sun Y, Tong Q.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1550-9. doi: 10.1152/ajpendo.00462.2011. Epub 2012 Mar 27.


NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes.

Zhao L, Hu P, Zhou Y, Purohit J, Hwang D.

Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E587-98. doi: 10.1152/ajpendo.00709.2010. Epub 2011 Jun 21.


Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents.

Kang W, Hong HJ, Guan J, Kim DG, Yang EJ, Koh G, Park D, Han CH, Lee YJ, Lee DH.

Metabolism. 2012 Mar;61(3):424-33. doi: 10.1016/j.metabol.2011.08.003. Epub 2011 Sep 25.


MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.

PLoS One. 2014 Feb 24;9(2):e89615. doi: 10.1371/journal.pone.0089615. eCollection 2014.


Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains.

Chalupny NJ, Aruffo A, Esselstyn JM, Chan PY, Bajorath J, Blake J, Gilliland LK, Ledbetter JA, Tepper MA.

Eur J Immunol. 1995 Oct;25(10):2978-84.


Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance.

Ceperuelo-Mallafré V, Duran X, Pachón G, Roche K, Garrido-Sánchez L, Vilarrasa N, Tinahones FJ, Vicente V, Pujol J, Vendrell J, Fernández-Veledo S.

J Clin Endocrinol Metab. 2014 May;99(5):E908-19. doi: 10.1210/jc.2013-3350. Epub 2014 Feb 10.


Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice.

Wueest S, Rapold RA, Schumann DM, Rytka JM, Schildknecht A, Nov O, Chervonsky AV, Rudich A, Schoenle EJ, Donath MY, Konrad D.

J Clin Invest. 2010 Jan;120(1):191-202. doi: 10.1172/JCI38388. Epub 2009 Dec 1.


5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.

Horrillo R, González-Périz A, Martínez-Clemente M, López-Parra M, Ferré N, Titos E, Morán-Salvador E, Deulofeu R, Arroyo V, Clària J.

J Immunol. 2010 Apr 1;184(7):3978-87. doi: 10.4049/jimmunol.0901355. Epub 2010 Mar 5.


Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways.

Jiao P, Chen Q, Shah S, Du J, Tao B, Tzameli I, Yan W, Xu H.

Diabetes. 2009 Jan;58(1):104-15. doi: 10.2337/db07-1344. Epub 2008 Oct 3.


Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner.

Cleghon V, Morrison DK.

J Biol Chem. 1994 Jul 1;269(26):17749-55.


Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor.

Samayawardhena LA, Hu J, Stein PL, Craig AW.

Cell Signal. 2006 Sep;18(9):1447-54. Epub 2006 Jan 25.


Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways.

Futosi K, Fodor S, Mócsai A.

Int Immunopharmacol. 2013 Dec;17(4):1185-97. doi: 10.1016/j.intimp.2013.11.010. Epub 2013 Nov 18. Review.


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