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Items: 1 to 20 of 150

1.

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.

Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, Lin K, Breen G, Wroe R, To AW, Leroy K, Causevic M, Usardi A, Robinson M, Noble W, Williamson R, Lunnon K, Kellie S, Reynolds CH, Bazenet C, Hodges A, Brion JP, Stephenson J, Simons JP, Lovestone S.

Mol Psychiatry. 2014 Jan;19(1):88-98. doi: 10.1038/mp.2012.163. Epub 2012 Nov 20.

2.

The regulation of p53 up-regulated modulator of apoptosis by JNK/c-Jun pathway in β-amyloid-induced neuron death.

Akhter R, Sanphui P, Das H, Saha P, Biswas SC.

J Neurochem. 2015 Sep;134(6):1091-103. doi: 10.1111/jnc.13128. Epub 2015 Apr 28.

3.

Role of Dickkopf-1, an antagonist of the Wnt/beta-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation.

Zhang QG, Wang R, Khan M, Mahesh V, Brann DW.

J Neurosci. 2008 Aug 20;28(34):8430-41. doi: 10.1523/JNEUROSCI.2752-08.2008.

4.

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

Scali C, Caraci F, Gianfriddo M, Diodato E, Roncarati R, Pollio G, Gaviraghi G, Copani A, Nicoletti F, Terstappen GC, Caricasole A.

Neurobiol Dis. 2006 Nov;24(2):254-65. Epub 2006 Aug 17.

PMID:
16919965
5.

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.

Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F.

J Neurosci. 2004 Jun 30;24(26):6021-7.

6.

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM.

J Neurosci. 2009 Jul 15;29(28):9078-89. doi: 10.1523/JNEUROSCI.1071-09.2009.

7.

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.

Purro SA, Dickins EM, Salinas PC.

J Neurosci. 2012 Mar 7;32(10):3492-8. doi: 10.1523/JNEUROSCI.4562-11.2012.

8.

Amyloid β peptide promotes lysosomal degradation of clusterin via sortilin in hippocampal primary neurons.

Wang Y, Qin X, Paudel HK.

Neurobiol Dis. 2017 Jul;103:78-88. doi: 10.1016/j.nbd.2017.04.003. Epub 2017 Apr 8.

PMID:
28396259
9.

Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons.

Abramovitch-Dahan C, Asraf H, Bogdanovic M, Sekler I, Bush AI, Hershfinkel M.

J Neurochem. 2016 Oct;139(2):221-233. doi: 10.1111/jnc.13760. Epub 2016 Sep 15.

10.

Neuroprotective effects of Wnt/β-catenin signaling pathway against Aβ -induced tau protein over-phosphorylation in PC12 cells.

Wang J, Jing Y, Song L, Xing Y.

Biochem Biophys Res Commun. 2016 Mar 18;471(4):628-32. doi: 10.1016/j.bbrc.2016.01.130. Epub 2016 Jan 22.

PMID:
26809093
11.

WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers.

Vargas JY, Ahumada J, Arrázola MS, Fuenzalida M, Inestrosa NC.

Exp Neurol. 2015 Feb;264:14-25. doi: 10.1016/j.expneurol.2014.11.005. Epub 2014 Nov 20.

PMID:
25450465
12.

[Involvement of Wnt/beta-catenin signaling in tripchlorolide protecting against oligomeric beta-amyloid-(1-42)-induced neuronal apoptosis].

Wu M, Zhu YG, Pan XD, Lin N, Zhang J, Chen XC.

Yao Xue Xue Bao. 2010 Jul;45(7):853-9. Chinese.

PMID:
20931782
13.

Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway.

Zhao X, Zou Y, Xu H, Fan L, Guo H, Li X, Li G, Zhang X, Dong M.

Brain Res. 2012 Oct 30;1482:13-21. doi: 10.1016/j.brainres.2012.09.010. Epub 2012 Sep 13.

PMID:
22982592
14.

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil.

Sellers KJ, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo AI, Jarosz-Griffiths HH, Watson IA, Xia W, Semenov M, Morin P, Hooper NM, Porter R, Preston J, Al-Shawi R, Baillie G, Lovestone S, Cuadrado A, Harte M, Simons P, Srivastava DP, Killick R.

Alzheimers Dement. 2018 Mar;14(3):306-317. doi: 10.1016/j.jalz.2017.09.008. Epub 2017 Oct 19.

15.

Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek.

Caneparo L, Huang YL, Staudt N, Tada M, Ahrendt R, Kazanskaya O, Niehrs C, Houart C.

Genes Dev. 2007 Feb 15;21(4):465-80.

16.

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, Davis RJ, Shirasaki Y, Greenberg ME.

J Neurosci. 2001 Oct 1;21(19):7551-60.

17.
18.

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG.

J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256.

19.

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils.

De Ferrari GV, Chacón MA, Barría MI, Garrido JL, Godoy JA, Olivares G, Reyes AE, Alvarez A, Bronfman M, Inestrosa NC.

Mol Psychiatry. 2003 Feb;8(2):195-208.

PMID:
12610652
20.

Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.

Chen YS, Chen SD, Wu CL, Huang SS, Yang DI.

Exp Neurol. 2014 Mar;253:63-71. doi: 10.1016/j.expneurol.2013.12.009. Epub 2013 Dec 22.

PMID:
24368194

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