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Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.

Tamaichi H, Sato M, Porter AC, Shimizu T, Mizutani S, Takagi M.

Cancer Sci. 2013 Feb;104(2):178-84. doi: 10.1111/cas.12067. Epub 2013 Jan 13.


The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells.

Deng S, Yan T, Nikolova T, Fuhrmann D, Nemecek A, Gödtel-Armbrust U, Kaina B, Wojnowski L.

Br J Pharmacol. 2015 May;172(9):2246-57. doi: 10.1111/bph.13046. Epub 2015 Feb 27.


Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells.

Gardner L, Malik R, Shimizu Y, Mullins N, ElShamy WM.

Breast Cancer Res. 2011 May 19;13(3):R53. doi: 10.1186/bcr2884.


Phosphorylation of Sp1 in response to DNA damage by ataxia telangiectasia-mutated kinase.

Olofsson BA, Kelly CM, Kim J, Hornsby SM, Azizkhan-Clifford J.

Mol Cancer Res. 2007 Dec;5(12):1319-30. doi: 10.1158/1541-7786.MCR-07-0374.


Proapoptotic BID is an ATM effector in the DNA-damage response.

Kamer I, Sarig R, Zaltsman Y, Niv H, Oberkovitz G, Regev L, Haimovich G, Lerenthal Y, Marcellus RC, Gross A.

Cell. 2005 Aug 26;122(4):593-603.


Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses.

Fan JR, Peng AL, Chen HC, Lo SC, Huang TH, Li TK.

DNA Repair (Amst). 2008 Mar 1;7(3):452-63. doi: 10.1016/j.dnarep.2007.12.002.


ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot.

Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A, Ikura T, Suzuki H, Mizutani S, Kanaar R, Tashiro S.

PLoS One. 2010 Oct 27;5(10):e13554. doi: 10.1371/journal.pone.0013554.


P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.

Ding H, Duan W, Zhu WG, Ju R, Srinivasan K, Otterson GA, Villalona-Calero MA.

Biochem Biophys Res Commun. 2003 Jun 13;305(4):950-6.


Phosphorylation of p300 by ATM controls the stability of NBS1.

Jang ER, Choi JD, Jeong G, Lee JS.

Biochem Biophys Res Commun. 2010 Jul 9;397(4):637-43. doi: 10.1016/j.bbrc.2010.05.060. Epub 2010 May 22.


An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.

Ramachandran S, Tran DD, Klebba-Faerber S, Kardinal C, Whetton AD, Tamura T.

RNA. 2011 Nov;17(11):1957-66. doi: 10.1261/rna.2820911. Epub 2011 Sep 21.


Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway.

Chiu YJ, Hour MJ, Lu CC, Chung JG, Kuo SC, Huang WW, Chen HJ, Jin YA, Yang JS.

J Orthop Res. 2011 Sep;29(9):1448-56. doi: 10.1002/jor.21398. Epub 2011 Mar 21.


Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.

Trinh BQ, Ko SY, Barengo N, Lin SY, Naora H.

Cancer Res. 2013 Jan 15;73(2):1000-10. doi: 10.1158/0008-5472.CAN-12-3538. Epub 2012 Dec 7.


DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.

Guo L, Liu X, Jiang Y, Nishikawa K, Plunkett W.

Mol Pharmacol. 2011 Aug;80(2):321-7. doi: 10.1124/mol.109.057125. Epub 2011 May 5.


Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.

Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y.

Mol Cell Biol. 2010 Apr;30(7):1620-33. doi: 10.1128/MCB.00810-09. Epub 2010 Feb 1.


CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines.

Pobst LJ, Ames MM.

Cancer Chemother Pharmacol. 2006 May;57(5):569-76. Epub 2005 Aug 11.


Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation.

Wei F, Xie Y, Tao L, Tang D.

Cell Signal. 2010 Nov;22(11):1783-9. doi: 10.1016/j.cellsig.2010.07.007. Epub 2010 Jul 15.


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