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Items: 1 to 20 of 93

1.

Crystal structure of 6-guanidinohexanoyl trypsin near the optimum pH reveals the acyl-enzyme intermediate to be deacylated.

Masuda Y, Nitanai Y, Mizutani R, Noguchi S.

Proteins. 2013 Mar;81(3):526-30. doi: 10.1002/prot.24206. Epub 2012 Dec 24.

PMID:
23161653
2.

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases.

Topf M, Várnai P, Schofield CJ, Richards WG.

Proteins. 2002 May 15;47(3):357-69.

PMID:
11948789
3.

Enzyme:substrate hydrogen bond shortening during the acylation phase of serine protease catalysis.

Fodor K, Harmat V, Neutze R, Szilágyi L, Gráf L, Katona G.

Biochemistry. 2006 Feb 21;45(7):2114-21.

PMID:
16475800
4.

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.

Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.

J Mol Biol. 2001 Apr 13;307(5):1451-86.

PMID:
11292354
5.

Details of the acyl-enzyme intermediate and the oxyanion hole in serine protease catalysis.

Whiting AK, Peticolas WL.

Biochemistry. 1994 Jan 18;33(2):552-61.

PMID:
8286385
6.

Molecular structure of the acyl-enzyme intermediate in beta-lactam hydrolysis at 1.7 A resolution.

Strynadka NC, Adachi H, Jensen SE, Johns K, Sielecki A, Betzel C, Sutoh K, James MN.

Nature. 1992 Oct 22;359(6397):700-5.

PMID:
1436034
8.

Crystallographic evidence for active-site dynamics in the hydrolytic aldehyde dehydrogenases. Implications for the deacylation step of the catalyzed reaction.

Muñoz-Clares RA, González-Segura L, Díaz-Sánchez AG.

Chem Biol Interact. 2011 May 30;191(1-3):137-46. doi: 10.1016/j.cbi.2010.12.024. Epub 2010 Dec 30.

PMID:
21195066
9.

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate.

Wilmouth RC, Edman K, Neutze R, Wright PA, Clifton IJ, Schneider TR, Schofield CJ, Hajdu J.

Nat Struct Biol. 2001 Aug;8(8):689-94.

PMID:
11473259
10.

The hydrolytic water molecule in trypsin, revealed by time-resolved Laue crystallography.

Singer PT, Smalås A, Carty RP, Mangel WF, Sweet RM.

Science. 1993 Jan 29;259(5095):669-73.

PMID:
8430314
11.
12.

Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

Cobessi D, Tête-Favier F, Marchal S, Branlant G, Aubry A.

J Mol Biol. 2000 Jun 30;300(1):141-52.

PMID:
10864505
13.

Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates.

Radisky ES, Lee JM, Lu CJ, Koshland DE Jr.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6835-40. Epub 2006 Apr 24.

14.

Length of the acyl carbonyl bond in acyl-serine proteases correlates with reactivity.

Tonge PJ, Carey PR.

Biochemistry. 1990 Dec 4;29(48):10723-7.

PMID:
2271679
16.

Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad.

Ruzzini AC, Ghosh S, Horsman GP, Foster LJ, Bolin JT, Eltis LD.

J Am Chem Soc. 2012 Mar 14;134(10):4615-24. doi: 10.1021/ja208544g. Epub 2012 Mar 5.

PMID:
22339283
17.

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution.

Katona G, Wilmouth RC, Wright PA, Berglund GI, Hajdu J, Neutze R, Schofield CJ.

J Biol Chem. 2002 Jun 14;277(24):21962-70. Epub 2002 Mar 14.

18.

Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.

Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW.

J Mol Biol. 2003 May 23;329(1):93-120.

PMID:
12742021
20.

X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.

Toyota E, Ng KK, Sekizaki H, Itoh K, Tanizawa K, James MN.

J Mol Biol. 2001 Jan 19;305(3):471-9.

PMID:
11152605

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