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Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii.

MacRae JI, Sheiner L, Nahid A, Tonkin C, Striepen B, McConville MJ.

Cell Host Microbe. 2012 Nov 15;12(5):682-92. doi: 10.1016/j.chom.2012.09.013.


Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii.

Nitzsche R, Zagoriy V, Lucius R, Gupta N.

J Biol Chem. 2016 Jan 1;291(1):126-41. doi: 10.1074/jbc.M114.624619. Epub 2015 Oct 30.


A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii.

Nitzsche R, Günay-Esiyok Ö, Tischer M, Zagoriy V, Gupta N.

J Biol Chem. 2017 Sep 15;292(37):15225-15239. doi: 10.1074/jbc.M117.802702. Epub 2017 Jul 18.


Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum.

MacRae JI, Dixon MW, Dearnley MK, Chua HH, Chambers JM, Kenny S, Bottova I, Tilley L, McConville MJ.

BMC Biol. 2013 Jun 13;11:67. doi: 10.1186/1741-7007-11-67.


A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and Virulence.

Blume M, Nitzsche R, Sternberg U, Gerlic M, Masters SL, Gupta N, McConville MJ.

Cell Host Microbe. 2015 Aug 12;18(2):210-20. doi: 10.1016/j.chom.2015.07.008.


Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis.

Blume M, Rodriguez-Contreras D, Landfear S, Fleige T, Soldati-Favre D, Lucius R, Gupta N.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12998-3003. doi: 10.1073/pnas.0903831106. Epub 2009 Jul 17.


Comprehensive Characterization of Toxoplasma Acyl Coenzyme A-Binding Protein TgACBP2 and Its Critical Role in Parasite Cardiolipin Metabolism.

Fu Y, Cui X, Fan S, Liu J, Zhang X, Wu Y, Liu Q.

MBio. 2018 Oct 23;9(5). pii: e01597-18. doi: 10.1128/mBio.01597-18.


Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii.

Fleige T, Pfaff N, Gross U, Bohne W.

Int J Parasitol. 2008 Aug;38(10):1121-32. doi: 10.1016/j.ijpara.2008.01.007. Epub 2008 Feb 13.


Host cell egress and invasion induce marked relocations of glycolytic enzymes in Toxoplasma gondii tachyzoites.

Pomel S, Luk FC, Beckers CJ.

PLoS Pathog. 2008 Oct;4(10):e1000188. doi: 10.1371/journal.ppat.1000188. Epub 2008 Oct 24.


Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways.

Lee IP, Evans AK, Yang C, Works MG, Kumar V, De Miguel Z, Manley NC, Sapolsky RM.

PLoS One. 2014 Oct 9;9(10):e109803. doi: 10.1371/journal.pone.0109803. eCollection 2014.


Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection.

Yu Y, Clippinger AJ, Alwine JC.

Trends Microbiol. 2011 Jul;19(7):360-7. doi: 10.1016/j.tim.2011.04.002. Epub 2011 May 12. Review.


Molecular cloning, organellar targeting and developmental expression of mitochondrial chaperone HSP60 in Toxoplasma gondii.

Toursel C, Dzierszinski F, Bernigaud A, Mortuaire M, Tomavo S.

Mol Biochem Parasitol. 2000 Dec;111(2):319-32.


The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.

Sheiner L, Vaidya AB, McFadden GI.

Curr Opin Microbiol. 2013 Aug;16(4):452-8. doi: 10.1016/j.mib.2013.07.003. Epub 2013 Aug 5. Review.


Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii.

Hartmann A, Hellmund M, Lucius R, Voelker DR, Gupta N.

J Biol Chem. 2014 Mar 7;289(10):6809-24. doi: 10.1074/jbc.M113.509406. Epub 2014 Jan 15.


Mechanism of dexamethasone in the context of Toxoplasma gondii infection.

Zhang J, Qin X, Zhu YU, Zhang S, Zhang XW, Lu HE.

Parasitology. 2017 Sep;144(11):1551-1559. doi: 10.1017/S0031182017001111. Epub 2017 Jun 27.


Induction of a stringent metabolic response in intracellular stages of Leishmania mexicana leads to increased dependence on mitochondrial metabolism.

Saunders EC, Ng WW, Kloehn J, Chambers JM, Ng M, McConville MJ.

PLoS Pathog. 2014 Jan;10(1):e1003888. doi: 10.1371/journal.ppat.1003888. Epub 2014 Jan 23.

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