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Items: 1 to 20 of 271

1.

The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration.

Klingauf M, Beck M, Berge U, Turgay Y, Heinzer S, Horvath P, Kroschewski R.

Biol Cell. 2013 Feb;105(2):91-107. doi: 10.1111/boc.201200030. Epub 2012 Dec 28.

PMID:
23157514
2.

The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.

Baljuls A, Beck M, Oenel A, Robubi A, Kroschewski R, Hekman M, Rudel T, Rapp UR.

J Biol Chem. 2012 Jun 29;287(27):23128-40. doi: 10.1074/jbc.M112.343780. Epub 2012 May 17.

3.

MEK-1 activates C-Raf through a Ras-independent mechanism.

Leicht DT, Balan V, Zhu J, Kaplun A, Bronisz A, Rana A, Tzivion G.

Biochim Biophys Acta. 2013 May;1833(5):976-86. doi: 10.1016/j.bbamcr.2013.01.015. Epub 2013 Jan 27.

4.
6.

Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF.

Baljuls A, DobrzyƄski M, Rauch J, Rauch N, Kolch W.

Cell Signal. 2016 Oct;28(10):1451-62. doi: 10.1016/j.cellsig.2016.06.019. Epub 2016 Jun 29.

PMID:
27368419
7.
9.

Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway.

Adler V, Qu Y, Smith SJ, Izotova L, Pestka S, Kung HF, Lin M, Friedman FK, Chie L, Chung D, Boutjdir M, Pincus MR.

Biochemistry. 2005 Aug 16;44(32):10784-95.

PMID:
16086581
10.
11.

Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

Marzec M, Kasprzycka M, Liu X, Raghunath PN, Wlodarski P, Wasik MA.

Oncogene. 2007 Feb 8;26(6):813-21. Epub 2006 Aug 7.

PMID:
16909118
12.

Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.

Zugasti O, Rul W, Roux P, Peyssonnaux C, Eychene A, Franke TF, Fort P, Hibner U.

Mol Cell Biol. 2001 Oct;21(19):6706-17.

13.

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.

Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T.

Nat Cell Biol. 2005 Aug;7(8):837-43. Epub 2005 Jul 24.

14.

T11TS inhibits Angiopoietin-1/Tie-2 signaling, EGFR activation and Raf/MEK/ERK pathway in brain endothelial cells restraining angiogenesis in glioma model.

Bhattacharya D, Chaudhuri S, Singh MK, Chaudhuri S.

Exp Mol Pathol. 2015 Jun;98(3):455-66. doi: 10.1016/j.yexmp.2015.03.026. Epub 2015 Mar 19.

PMID:
25797371
15.

ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7.

Lu Z, Yang H, Sutton MN, Yang M, Clarke CH, Liao WS, Bast RC Jr.

Cell Death Differ. 2014 Aug;21(8):1275-89. doi: 10.1038/cdd.2014.48. Epub 2014 Apr 25.

16.

Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway.

Woods D, Cherwinski H, Venetsanakos E, Bhat A, Gysin S, Humbert M, Bray PF, Saylor VL, McMahon M.

Mol Cell Biol. 2001 May;21(9):3192-205.

17.

Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.

Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T.

Cancer Res. 2013 Jul 1;73(13):4050-4060. doi: 10.1158/0008-5472.CAN-12-3937. Epub 2013 May 10.

18.

Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression.

Kim DI, Lee SJ, Lee SB, Park K, Kim WJ, Moon SK.

Carcinogenesis. 2008 Sep;29(9):1701-9. doi: 10.1093/carcin/bgn055. Epub 2008 Feb 22.

PMID:
18296682
19.

Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases.

Pan MR, Chang HC, Hung WC.

Cell Signal. 2008 Jun;20(6):1134-41. doi: 10.1016/j.cellsig.2008.02.004. Epub 2008 Feb 15.

PMID:
18374541
20.

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