Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 89


Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.

Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte JC, Matsui Y.

Genes Dev. 2012 Nov 15;26(22):2477-82. doi: 10.1101/gad.202242.112.


Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.

J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746. Epub 2012 Sep 5. Erratum in: J Biol Chem. 2013 Apr 26;288(17):12214.


Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.

Cho WK, Jang MK, Huang K, Pise-Masison CA, Brady JN.

J Virol. 2010 Dec;84(24):12801-9. doi: 10.1128/JVI.00943-10. Epub 2010 Oct 6.


Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb.

Van Herreweghe E, Egloff S, Goiffon I, Jády BE, Froment C, Monsarrat B, Kiss T.

EMBO J. 2007 Aug 8;26(15):3570-80. Epub 2007 Jul 5.


The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK.

Krueger BJ, Varzavand K, Cooper JJ, Price DH.

PLoS One. 2010 Aug 23;5(8):e12335. doi: 10.1371/journal.pone.0012335.


7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.

Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM.

Proc Natl Acad Sci U S A. 2009 May 12;106(19):7798-803. doi: 10.1073/pnas.0903188106. Epub 2009 Apr 27.


RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP.

Muniz L, Egloff S, Kiss T.

Nucleic Acids Res. 2013 Apr;41(8):4686-98. doi: 10.1093/nar/gkt159. Epub 2013 Mar 6.


PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.

Gudipaty SA, McNamara RP, Morton EL, D'Orso I.

Mol Cell Biol. 2015 Nov;35(22):3810-28. doi: 10.1128/MCB.00226-15. Epub 2015 Aug 31.


A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.

He N, Jahchan NS, Hong E, Li Q, Bayfield MA, Maraia RJ, Luo K, Zhou Q.

Mol Cell. 2008 Mar 14;29(5):588-99. doi: 10.1016/j.molcel.2008.01.003. Epub 2008 Jan 31.


Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.

Barboric M, Yik JH, Czudnochowski N, Yang Z, Chen R, Contreras X, Geyer M, Matija Peterlin B, Zhou Q.

Nucleic Acids Res. 2007;35(6):2003-12. Epub 2007 Mar 6.


LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated.

Krueger BJ, Jeronimo C, Roy BB, Bouchard A, Barrandon C, Byers SA, Searcey CE, Cooper JJ, Bensaude O, Cohen EA, Coulombe B, Price DH.

Nucleic Acids Res. 2008 Apr;36(7):2219-29. doi: 10.1093/nar/gkn061. Epub 2008 Feb 16.


Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M.

J Biol Chem. 2012 Jan 6;287(2):1090-9. doi: 10.1074/jbc.M111.282855. Epub 2011 Nov 14.


Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.

McNamara RP, McCann JL, Gudipaty SA, D'Orso I.

Cell Rep. 2013 Dec 12;5(5):1256-68. doi: 10.1016/j.celrep.2013.11.003. Epub 2013 Dec 5.


PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.

Chen R, Liu M, Li H, Xue Y, Ramey WN, He N, Ai N, Luo H, Zhu Y, Zhou N, Zhou Q.

Genes Dev. 2008 May 15;22(10):1356-68. doi: 10.1101/gad.1636008.


Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb.

C Quaresma AJ, Bugai A, Barboric M.

Nucleic Acids Res. 2016 Sep 19;44(16):7527-39. doi: 10.1093/nar/gkw585. Epub 2016 Jul 1. Review.


Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells.

Fujinaga K, Luo Z, Schaufele F, Peterlin BM.

J Biol Chem. 2015 Jan 16;290(3):1829-36. doi: 10.1074/jbc.M114.605816. Epub 2014 Dec 9.


HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.

Byers SA, Price JP, Cooper JJ, Li Q, Price DH.

J Biol Chem. 2005 Apr 22;280(16):16360-7. Epub 2005 Feb 14.


Supplemental Content

Support Center