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Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction.

Kubli DA, Zhang X, Lee Y, Hanna RA, Quinsay MN, Nguyen CK, Jimenez R, Petrosyan S, Murphy AN, Gustafsson AB.

J Biol Chem. 2013 Jan 11;288(2):915-26. doi: 10.1074/jbc.M112.411363. Epub 2012 Nov 14.


Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.

Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd.

Circ Res. 2015 Jul 31;117(4):346-51. doi: 10.1161/CIRCRESAHA.117.306859. Epub 2015 Jun 2.


Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

Huang C, Andres AM, Ratliff EP, Hernandez G, Lee P, Gottlieb RA.

PLoS One. 2011;6(6):e20975. doi: 10.1371/journal.pone.0020975. Epub 2011 Jun 8.


Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice.

Williams JA, Ni HM, Ding Y, Ding WX.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G324-40. doi: 10.1152/ajpgi.00108.2015. Epub 2015 Jul 9. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2):G142.


Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis.

Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K.

Toxicology. 2014 Aug 1;322:43-50. doi: 10.1016/j.tox.2014.04.008. Epub 2014 May 4.


Central Parkin: The evolving role of Parkin in the heart.

Dorn GW 2nd.

Biochim Biophys Acta. 2016 Aug;1857(8):1307-12. doi: 10.1016/j.bbabio.2016.03.014. Epub 2016 Mar 16. Review.


Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice.

Gong G, Song M, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd.

Science. 2015 Dec 4;350(6265):aad2459. doi: 10.1126/science.aad2459. Epub 2015 Dec 3.


Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.

Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW 2nd.

Circ Res. 2014 Jan 17;114(2):257-65. doi: 10.1161/CIRCRESAHA.114.302734. Epub 2013 Nov 5.


Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis.

Schiattarella GG, Cattaneo F, Pironti G, Magliulo F, Carotenuto G, Pirozzi M, Polishchuk R, Borzacchiello D, Paolillo R, Oliveti M, Boccella N, Avvedimento M, Sepe M, Lombardi A, Busiello RA, Trimarco B, Esposito G, Feliciello A, Perrino C.

PLoS One. 2016 May 2;11(5):e0154076. doi: 10.1371/journal.pone.0154076. eCollection 2016. Erratum in: PLoS One. 2016;11(7):e0158934.


Parkin Regulates Mitochondrial Autophagy After Myocardial Infarction in Rats.

Wu L, Maimaitirexiati X, Jiang Y, Liu L.

Med Sci Monit. 2016 May 8;22:1553-9.


Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.

Kageyama Y, Hoshijima M, Seo K, Bedja D, Sysa-Shah P, Andrabi SA, Chen W, Höke A, Dawson VL, Dawson TM, Gabrielson K, Kass DA, Iijima M, Sesaki H.

EMBO J. 2014 Dec 1;33(23):2798-813. doi: 10.15252/embj.201488658. Epub 2014 Oct 27.


Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.

Han JY, Kang MJ, Kim KH, Han PL, Kim HS, Ha JY, Son JH.

J Biol Chem. 2015 Apr 17;290(16):10325-35. doi: 10.1074/jbc.M114.624767. Epub 2015 Feb 25.


Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons.

Cai Q, Zakaria HM, Simone A, Sheng ZH.

Curr Biol. 2012 Mar 20;22(6):545-52. doi: 10.1016/j.cub.2012.02.005. Epub 2012 Feb 16.


Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes.

Lee Y, Lee HY, Hanna RA, Gustafsson ÅB.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1924-31. doi: 10.1152/ajpheart.00368.2011. Epub 2011 Sep 2.


Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction.

Piquereau J, Godin R, Deschênes S, Bessi VL, Mofarrahi M, Hussain SN, Burelle Y.

Autophagy. 2013 Nov 1;9(11):1837-51. doi: 10.4161/auto.26502. Epub 2013 Oct 3.


Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains.

Ye X, Sun X, Starovoytov V, Cai Q.

Hum Mol Genet. 2015 May 15;24(10):2938-51. doi: 10.1093/hmg/ddv056. Epub 2015 Feb 12.


Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.

Narendra D, Tanaka A, Suen DF, Youle RJ.

J Cell Biol. 2008 Dec 1;183(5):795-803. doi: 10.1083/jcb.200809125. Epub 2008 Nov 24.


Mitochondrial dysfunction and oxidative damage in parkin-deficient mice.

Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J.

J Biol Chem. 2004 Apr 30;279(18):18614-22. Epub 2004 Feb 24.


Acetylcholine Attenuates Hypoxia/Reoxygenation Injury by Inducing Mitophagy Through PINK1/Parkin Signal Pathway in H9c2 Cells.

Sun L, Zhao M, Yang Y, Xue RQ, Yu XJ, Liu JK, Zang WJ.

J Cell Physiol. 2016 May;231(5):1171-81. doi: 10.1002/jcp.25215. Epub 2015 Oct 23.


p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both.

Narendra D, Kane LA, Hauser DN, Fearnley IM, Youle RJ.

Autophagy. 2010 Nov;6(8):1090-106.

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