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Quality controls in cellular immunotherapies: rapid assessment of clinical grade dendritic cells by gene expression profiling.

Castiello L, Sabatino M, Zhao Y, Tumaini B, Ren J, Ping J, Wang E, Wood LV, Marincola FM, Puri RK, Stroncek DF.

Mol Ther. 2013 Feb;21(2):476-84. doi: 10.1038/mt.2012.89. Epub 2012 Nov 13. Erratum in: Mol Ther. 2013 Feb;21(2):495.


Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies.

Jin P, Han TH, Ren J, Saunders S, Wang E, Marincola FM, Stroncek DF.

J Transl Med. 2010 Jan 15;8:4. doi: 10.1186/1479-5876-8-4.


Microarray-based gene expression analysis as a process characterization tool to establish comparability of complex biological products: scale-up of a whole-cell immunotherapy product.

Wang M, Senger RS, Paredes C, Banik GG, Lin A, Papoutsakis ET.

Biotechnol Bioeng. 2009 Nov 1;104(4):796-808. doi: 10.1002/bit.22441.


Transient downregulation of monocyte-derived dendritic-cell differentiation, function, and survival during tumoral progression and regression in an in vivo canine model of transmissible venereal tumor.

Liu CC, Wang YS, Lin CY, Chuang TF, Liao KW, Chi KH, Chen MF, Chiang HC, Chu RM.

Cancer Immunol Immunother. 2008 Apr;57(4):479-91. Epub 2007 Aug 21.


Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients.

Jacobs JF, Hoogerbrugge PM, de Rakt MW, Aarntzen EH, Figdor CG, Adema GJ, de Vries IJ.

Pediatr Blood Cancer. 2007 Dec;49(7):924-7.


Generation of dendritic cells for immunotherapy is minimally impaired by granulocytes in the monocyte preparation.

ten Brinke A, Karsten ML, Dieker MC, Zwaginga JJ, Vrielink H, Marieke van Ham S.

Immunobiology. 2006;211(6-8):633-40. Epub 2006 Jul 5.


Menstrual blood-derived stromal stem cells inhibit optimal generation and maturation of human monocyte-derived dendritic cells.

Bozorgmehr M, Moazzeni SM, Salehnia M, Sheikhian A, Nikoo S, Zarnani AH.

Immunol Lett. 2014 Dec;162(2 Pt B):239-46. doi: 10.1016/j.imlet.2014.10.005. Epub 2014 Oct 18.


Evaluation of gene expression profiles of immature dendritic cells prepared from peripheral blood mononuclear cells.

Shin JW, Jin P, Fan Y, Slezak S, David-Ocampo V, Khuu HM, Read EJ, Wang E, Marincola FM, Stroncek DF.

Transfusion. 2008 Apr;48(4):647-57. doi: 10.1111/j.1537-2995.2007.01615.x. Epub 2008 Feb 12.


Human monocyte-derived dendritic cells from leukoreduction system chambers after plateletpheresis are functional in an in vitro co-culture assay with intestinal epithelial cells.

Tiscornia I, Sánchez-Martins V, Hernández A, Bollati-Fogolín M.

J Immunol Methods. 2012 Oct 31;384(1-2):164-70. doi: 10.1016/j.jim.2012.07.005. Epub 2012 Jul 24.


Polarization of human monocyte-derived dendritic cells to DC1 by in vitro stimulation with Newcastle Disease Virus.

Fournier P, Arnold A, Schirrmacher V.

J BUON. 2009 Sep;14 Suppl 1:S111-22.


Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.

Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L.

Blood. 2011 Mar 3;117(9):2625-39. doi: 10.1182/blood-2010-06-292136. Epub 2010 Dec 10.


Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy.

Prins RM, Soto H, Konkankit V, Odesa SK, Eskin A, Yong WH, Nelson SF, Liau LM.

Clin Cancer Res. 2011 Mar 15;17(6):1603-15. doi: 10.1158/1078-0432.CCR-10-2563. Epub 2010 Dec 6.


Comparative evaluation of techniques for the manufacturing of dendritic cell-based cancer vaccines.

Dohnal AM, Graffi S, Witt V, Eichstill C, Wagner D, Ul-Haq S, Wimmer D, Felzmann T.

J Cell Mol Med. 2009 Jan;13(1):125-35. doi: 10.1111/j.1582-4934.2008.00304.x. Epub 2008 Mar 17.


Monocyte derived dendritic cells generated by IFN-alpha acquire mature dendritic and natural killer cell properties as shown by gene expression analysis.

Korthals M, Safaian N, Kronenwett R, Maihöfer D, Schott M, Papewalis C, Diaz Blanco E, Winter M, Czibere A, Haas R, Kobbe G, Fenk R.

J Transl Med. 2007 Sep 25;5:46.


Impact of interleukin-10 on phenotype and gene expression during early monocyte differentiation into dendritic cells.

Schwarz AM, Banning-Eichenseer U, Seidel K, Mauz-Körholz C, Körholz D, Staege MS.

Anticancer Res. 2013 Nov;33(11):4791-8.


Autoimmune regulator induced changes in the gene expression profile of human monocyte-dendritic cell-lineage.

Sillanpää N, Magureanu CG, Murumägi A, Reinikainen A, West A, Manninen A, Lahti M, Ranki A, Saksela K, Krohn K, Lahesmaa R, Peterson P.

Mol Immunol. 2004 Nov;41(12):1185-98.


Generation of canine dendritic cells from peripheral blood monocytes without using purified cytokines.

Wijewardana V, Sugiura K, Oichi T, Fujimoto M, Akazawa T, Hatoya S, Inaba M, Ikehara S, Jayaweera TS, Inaba T.

Vet Immunol Immunopathol. 2006 Nov 15;114(1-2):37-48. Epub 2006 Aug 14.


Efficient monocyte-derived dendritic cell generation in patients with acute myeloid leukemia after chemotherapy treatment: application to active immunotherapy.

Royer PJ, Bougras G, Ebstein F, Leveque L, Tanguy-Royer S, Simon T, Juge-Morineau N, Chevallier P, Harousseau JL, Gregoire M.

Exp Hematol. 2008 Mar;36(3):329-39. doi: 10.1016/j.exphem.2007.11.001. Epub 2008 Jan 22.


Monocyte-derived DC maturation strategies and related pathways: a transcriptional view.

Castiello L, Sabatino M, Jin P, Clayberger C, Marincola FM, Krensky AM, Stroncek DF.

Cancer Immunol Immunother. 2011 Apr;60(4):457-66. doi: 10.1007/s00262-010-0954-6. Epub 2011 Jan 22. Review.

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