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Items: 1 to 20 of 78

1.

siRNA has greatly elevated mismatch tolerance at 3'-UTR sites.

Wei N, Zhang L, Huang H, Chen Y, Zheng J, Zhou X, Yi F, Du Q, Liang Z.

PLoS One. 2012;7(11):e49309. doi: 10.1371/journal.pone.0049309. Epub 2012 Nov 8.

2.

Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7.

Ravon M, Berrera M, Ebeling M, Certa U.

RNA Biol. 2012 Jan;9(1):87-97. doi: 10.4161/rna.9.1.18121. Epub 2012 Jan 1.

3.

Expression determinants of mammalian argonaute proteins in mediating gene silencing.

Valdmanis PN, Gu S, Schüermann N, Sethupathy P, Grimm D, Kay MA.

Nucleic Acids Res. 2012 Apr;40(8):3704-13. doi: 10.1093/nar/gkr1274. Epub 2011 Dec 30.

4.

Positional effects and strand preference of RNA interference against hepatitis C virus target sequences.

Smith RM, Smolic R, Volarevic M, Wu GY.

J Viral Hepat. 2007 Mar;14(3):194-212.

PMID:
17305886
5.

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites.

Du Q, Thonberg H, Wang J, Wahlestedt C, Liang Z.

Nucleic Acids Res. 2005 Mar 21;33(5):1671-7. Print 2005. Erratum in: Nucleic Acids Res. 2005;33(11):3698.

6.

Analysis of siRNA specificity on targets with double-nucleotide mismatches.

Dahlgren C, Zhang HY, Du Q, Grahn M, Norstedt G, Wahlestedt C, Liang Z.

Nucleic Acids Res. 2008 May;36(9):e53. doi: 10.1093/nar/gkn190. Epub 2008 Apr 17.

7.
8.

Structural evolution and functional diversification analyses of argonaute protein.

Wei KF, Wu LJ, Chen J, Chen YF, Xie DX.

J Cell Biochem. 2012 Aug;113(8):2576-85. doi: 10.1002/jcb.24133.

PMID:
22415963
9.

Platination of the siRNA sense-strand modulates both efficacy and selectivity in vitro.

Hägerlöf M, Hedman H, Elmroth SK.

Biochem Biophys Res Commun. 2007 Sep 14;361(1):14-9. Epub 2007 Jul 6.

PMID:
17632077
10.

Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units.

Alagia A, Terrazas M, Eritja R.

Molecules. 2015 Apr 24;20(5):7602-19. doi: 10.3390/molecules20057602.

11.

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

Lian SL, Li S, Abadal GX, Pauley BA, Fritzler MJ, Chan EK.

RNA. 2009 May;15(5):804-13. doi: 10.1261/rna.1229409. Epub 2009 Mar 26.

12.

Comparison between the repression potency of siRNA targeting the coding region and the 3'-untranslated region of mRNA.

Lai CF, Chen CY, Au LC.

Biomed Res Int. 2013;2013:637850. doi: 10.1155/2013/637850. Epub 2013 Jun 12.

13.

Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects.

Petri S, Dueck A, Lehmann G, Putz N, Rüdel S, Kremmer E, Meister G.

RNA. 2011 Apr;17(4):737-49. doi: 10.1261/rna.2348111. Epub 2011 Mar 2.

15.

Effect of the guide strand 3'-end structure on the gene-silencing potency of asymmetric siRNA.

Hong SW, Park JH, Yun S, Lee CH, Shin C, Lee DK.

Biochem J. 2014 Aug 1;461(3):427-34. doi: 10.1042/BJ20140407.

PMID:
24800867
16.

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.

Vickers TA, Lima WF, Wu H, Nichols JG, Linsley PS, Crooke ST.

Nucleic Acids Res. 2009 Nov;37(20):6927-41. doi: 10.1093/nar/gkp735. Epub 2009 Sep 18.

17.

Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.

Wu L, Fan J, Belasco JG.

Curr Biol. 2008 Sep 9;18(17):1327-32. doi: 10.1016/j.cub.2008.07.072.

18.

Functional dissection of a plant Argonaute.

Fátyol K, Ludman M, Burgyán J.

Nucleic Acids Res. 2016 Feb 18;44(3):1384-97. doi: 10.1093/nar/gkv1371. Epub 2015 Dec 15.

19.

Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi.

Chen S, Chahar HS, Abraham S, Wu H, Pierson TC, Wang XA, Manjunath N.

PLoS One. 2011;6(11):e27551. doi: 10.1371/journal.pone.0027551. Epub 2011 Nov 10.

20.

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways.

Okamura K, Ishizuka A, Siomi H, Siomi MC.

Genes Dev. 2004 Jul 15;18(14):1655-66. Epub 2004 Jul 1.

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