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MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.

Testa JS, Shetty V, Hafner J, Nickens Z, Kamal S, Sinnathamby G, Philip R.

PLoS One. 2012;7(11):e48484. doi: 10.1371/journal.pone.0048484. Epub 2012 Nov 7.


A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses.

QuiƱones-Parra SM, Clemens EB, Wang Z, Croom HA, Kedzierski L, McVernon J, Vijaykrishna D, Kedzierska K.

J Virol. 2016 Jul 11;90(15):6936-47. doi: 10.1128/JVI.00349-16. Print 2016 Aug 1.


Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.

Valkenburg SA, Gras S, Guillonneau C, La Gruta NL, Thomas PG, Purcell AW, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K.

PLoS Pathog. 2010 Aug 12;6(8):e1001039. doi: 10.1371/journal.ppat.1001039.


Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections.

Zhong W, Liu F, Dong L, Lu X, Hancock K, Reinherz EL, Katz JM, Sambhara S.

PLoS One. 2010 May 11;5(5):e10583. doi: 10.1371/journal.pone.0010583.


Conserved MHC class I-presented dengue virus epitopes identified by immunoproteomics analysis are targets for cross-serotype reactive T-cell response.

Testa JS, Shetty V, Sinnathamby G, Nickens Z, Hafner J, Kamal S, Zhang X, Jett M, Philip R.

J Infect Dis. 2012 Feb 15;205(4):647-55. doi: 10.1093/infdis/jir814. Epub 2012 Jan 13.


Universal H1N1 influenza vaccine development: identification of consensus class II hemagglutinin and neuraminidase epitopes derived from strains circulating between 1980 and 2011.

Moise L, Terry F, Ardito M, Tassone R, Latimer H, Boyle C, Martin WD, De Groot AS.

Hum Vaccin Immunother. 2013 Jul;9(7):1598-607. doi: 10.4161/hv.25598. Epub 2013 Jul 11.


Viral escape by selection of cytotoxic T cell-resistant variants in influenza A virus pneumonia.

Price GE, Ou R, Jiang H, Huang L, Moskophidis D.

J Exp Med. 2000 Jun 5;191(11):1853-67.


A human CD4+ T cell epitope in the influenza hemagglutinin is cross-reactive to influenza A virus subtypes and to influenza B virus.

Babon JA, Cruz J, Ennis FA, Yin L, Terajima M.

J Virol. 2012 Sep;86(17):9233-43. doi: 10.1128/JVI.06325-11. Epub 2012 Jun 20. Erratum in: J Virol. 2013 Aug;87(16):9396.


The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans.

Choo JA, Liu J, Toh X, Grotenbreg GM, Ren EC.

J Virol. 2014 Sep;88(18):10613-23. doi: 10.1128/JVI.00855-14. Epub 2014 Jul 2.


Differential processing and presentation of the H-2D(b)-restricted epitope from two different strains of influenza virus nucleoprotein.

Potter P, Tourdot S, Blanchard T, Smith GL, Gould KG.

J Gen Virol. 2001 May;82(Pt 5):1069-74.


Structural and Biochemical Analyses of Swine Major Histocompatibility Complex Class I Complexes and Prediction of the Epitope Map of Important Influenza A Virus Strains.

Fan S, Wu Y, Wang S, Wang Z, Jiang B, Liu Y, Liang R, Zhou W, Zhang N, Xia C.

J Virol. 2016 Jul 11;90(15):6625-41. doi: 10.1128/JVI.00119-16. Print 2016 Aug 1.


A CTL-based liposomal vaccine capable of inducing protection against heterosubtypic influenza viruses in HLA-A*0201 transgenic mice.

Matsui M, Kohyama S, Suda T, Yokoyama S, Mori M, Kobayashi A, Taneichi M, Uchida T.

Biochem Biophys Res Commun. 2010 Jan 15;391(3):1494-9. doi: 10.1016/j.bbrc.2009.12.100.


Heterosubtypic immunity against human influenza A viruses, including recently emerged avian H5 and H9 viruses, induced by FLU-ISCOM vaccine in mice requires both cytotoxic T-lymphocyte and macrophage function.

Sambhara S, Kurichh A, Miranda R, Tumpey T, Rowe T, Renshaw M, Arpino R, Tamane A, Kandil A, James O, Underdown B, Klein M, Katz J, Burt D.

Cell Immunol. 2001 Aug 1;211(2):143-53.


Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus.

Tu W, Mao H, Zheng J, Liu Y, Chiu SS, Qin G, Chan PL, Lam KT, Guan J, Zhang L, Guan Y, Yuen KY, Peiris JS, Lau YL.

J Virol. 2010 Jul;84(13):6527-35. doi: 10.1128/JVI.00519-10. Epub 2010 Apr 21.


HLA class I molecules consistently present internal influenza epitopes.

Wahl A, Schafer F, Bardet W, Buchli R, Air GM, Hildebrand WH.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):540-5. doi: 10.1073/pnas.0811271106. Epub 2009 Jan 2.


Multiple distinct forms of CD8+ T cell cross-reactivity and specificities revealed after 2009 H1N1 influenza A virus infection in mice.

Guo H, Topham DJ.

PLoS One. 2012;7(9):e46166. doi: 10.1371/journal.pone.0046166. Epub 2012 Sep 27.


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