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Items: 1 to 20 of 84

1.

Englerin a selectively induces necrosis in human renal cancer cells.

Sulzmaier FJ, Li Z, Nakashige ML, Fash DM, Chain WJ, Ramos JW.

PLoS One. 2012;7(10):e48032. doi: 10.1371/journal.pone.0048032. Epub 2012 Oct 22.

2.

Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy.

Williams RT, Yu AL, Diccianni MB, Theodorakis EA, Batova A.

J Exp Clin Cancer Res. 2013 Aug 20;32:57. doi: 10.1186/1756-9966-32-57. Erratum in: J Exp Clin Cancer Res. 2014;33:95.

3.

Total synthesis of englerin A.

Nicolaou KC, Kang Q, Ng SY, Chen DY.

J Am Chem Soc. 2010 Jun 16;132(23):8219-22. doi: 10.1021/ja102927n.

PMID:
20496885
4.

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.

Carson C, Raman P, Tullai J, Xu L, Henault M, Thomas E, Yeola S, Lao J, McPate M, Verkuyl JM, Marsh G, Sarber J, Amaral A, Bailey S, Lubicka D, Pham H, Miranda N, Ding J, Tang HM, Ju H, Tranter P, Ji N, Krastel P, Jain RK, Schumacher AM, Loureiro JJ, George E, Berellini G, Ross NT, Bushell SM, Erdemli G, Solomon JM.

PLoS One. 2015 Jun 22;10(6):e0127498. doi: 10.1371/journal.pone.0127498. eCollection 2015.

5.

Englerin A induces an acute inflammatory response and reveals lipid metabolism and ER stress as targetable vulnerabilities in renal cell carcinoma.

Batova A, Altomare D, Creek KE, Naviaux RK, Wang L, Li K, Green E, Williams R, Naviaux JC, Diccianni M, Yu AL.

PLoS One. 2017 Mar 15;12(3):e0172632. doi: 10.1371/journal.pone.0172632. eCollection 2017.

6.

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ, Waldmann H.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. doi: 10.1002/anie.201411511. Epub 2015 Feb 23.

PMID:
25707820
7.

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent.

Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutler JA, Linehan WM, Neckers L.

Oncotarget. 2015 Oct 6;6(30):29963-74. doi: 10.18632/oncotarget.4676.

8.

Synthesis of a stable and orally bioavailable englerin analogue.

Fash DM, Peer CJ, Li Z, Talisman IJ, Hayavi S, Sulzmaier FJ, Ramos JW, Sourbier C, Neckers L, Figg WD, Beutler JA, Chain WJ.

Bioorg Med Chem Lett. 2016 Jun 1;26(11):2641-4. doi: 10.1016/j.bmcl.2016.04.016. Epub 2016 Apr 8.

9.

Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile.

Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C, Fröhlich R, Habenberger P, Waldmann H, Christmann M.

Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3998-4002. doi: 10.1002/anie.201007790. Epub 2011 Mar 29. No abstract available.

PMID:
21472928
10.

Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA.

Org Lett. 2009 Jan 1;11(1):57-60. doi: 10.1021/ol802339w.

11.

Formal synthesis of (-)-englerin A and cytotoxicity studies of truncated englerins.

Xu J, Caro-Diaz EJ, Batova A, Sullivan SD, Theodorakis EA.

Chem Asian J. 2012 May;7(5):1052-60. doi: 10.1002/asia.201101021. Epub 2012 Mar 13.

12.

Asymmetric Total Synthesis of (-)-Englerin A through Catalytic Diastereo- and Enantioselective Carbonyl Ylide Cycloaddition.

Hanari T, Shimada N, Kurosaki Y, Thrimurtulu N, Nambu H, Anada M, Hashimoto S.

Chemistry. 2015 Aug 10;21(33):11671-6. doi: 10.1002/chem.201502009. Epub 2015 Jul 15.

PMID:
26179743
13.

Chlorinated englerins with selective inhibition of renal cancer cell growth.

Akee RK, Ransom T, Ratnayake R, McMahon JB, Beutler JA.

J Nat Prod. 2012 Mar 23;75(3):459-63. doi: 10.1021/np200905u. Epub 2012 Jan 26.

14.

Synthesis and Biological Evaluation of New (-)-Englerin Analogues.

López-Suárez L, Riesgo L, Bravo F, Ransom TT, Beutler JA, Echavarren AM.

ChemMedChem. 2016 May 6;11(9):1003-7. doi: 10.1002/cmdc.201600040. Epub 2016 Mar 23.

15.

Chemical synthesis of the englerins.

Pouwer RH, Richard JA, Tseng CC, Chen DY.

Chem Asian J. 2012 Jan 2;7(1):22-35. doi: 10.1002/asia.201100780. Epub 2011 Dec 8. Review.

PMID:
22162365
16.

A brief synthesis of (-)-englerin A.

Li Z, Nakashige M, Chain WJ.

J Am Chem Soc. 2011 May 4;133(17):6553-6. doi: 10.1021/ja201921j. Epub 2011 Apr 8.

PMID:
21476574
17.

Chemical synthesis and biological evaluation of the englerin analogues.

Chan KP, Chen DY.

ChemMedChem. 2011 Mar 7;6(3):420-3. doi: 10.1002/cmdc.201000544. Epub 2011 Jan 18. No abstract available.

PMID:
21360817
18.

Sodium meta-arsenite induces reactive oxygen species-dependent apoptosis, necrosis, and autophagy in both androgen-sensitive and androgen-insensitive prostate cancer cells.

Kim Y, Jeong IG, You D, Song SH, Suh N, Jang SW, Kim S, Hwang JJ, Kim CS.

Anticancer Drugs. 2014 Jan;25(1):53-62. doi: 10.1097/CAD.0000000000000013.

PMID:
24100277
19.

Enantioselective formal synthesis of (-)-englerin A via a Rh-catalyzed [4 + 3] cycloaddition reaction.

Xu J, Caro-Diaz EJ, Theodorakis EA.

Org Lett. 2010 Aug 20;12(16):3708-11. doi: 10.1021/ol1015652.

20.

Englerins: A Comprehensive Review.

Wu Z, Zhao S, Fash DM, Li Z, Chain WJ, Beutler JA.

J Nat Prod. 2017 Mar 24;80(3):771-781. doi: 10.1021/acs.jnatprod.6b01167. Epub 2017 Feb 7. Review.

PMID:
28170253

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