Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 124

1.

The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.

Behnke MS, Fentress SJ, Mashayekhi M, Li LX, Taylor GA, Sibley LD.

PLoS Pathog. 2012;8(11):e1002992. doi: 10.1371/journal.ppat.1002992. Epub 2012 Nov 8.

2.

The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response.

Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP.

PLoS Pathog. 2012;8(6):e1002784. doi: 10.1371/journal.ppat.1002784. Epub 2012 Jun 28.

3.

The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD.

Cell Host Microbe. 2014 May 14;15(5):537-50. doi: 10.1016/j.chom.2014.04.002.

4.

A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.

Fleckenstein MC, Reese ML, Könen-Waisman S, Boothroyd JC, Howard JC, Steinfeldt T.

PLoS Biol. 2012;10(7):e1001358. doi: 10.1371/journal.pbio.1001358. Epub 2012 Jul 10.

5.

Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.

Selleck EM, Fentress SJ, Beatty WL, Degrandi D, Pfeffer K, Virgin HW 4th, Macmicking JD, Sibley LD.

PLoS Pathog. 2013;9(4):e1003320. doi: 10.1371/journal.ppat.1003320. Epub 2013 Apr 25.

6.

Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination.

Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP.

MBio. 2015 Feb 24;6(2):e02280. doi: 10.1128/mBio.02280-14.

7.

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse.

Alaganan A, Fentress SJ, Tang K, Wang Q, Sibley LD.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1126-31. doi: 10.1073/pnas.1313501111. Epub 2014 Jan 3.

8.

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.

Fox BA, Rommereim LM, Guevara RB, Falla A, Hortua Triana MA, Sun Y, Bzik DJ.

MBio. 2016 May 10;7(3). pii: e00193-16. doi: 10.1128/mBio.00193-16.

9.

Association of ROP18 and ROP5 was efficient as a marker of virulence in atypical isolates of Toxoplasma gondii obtained from pigs and goats in Piauí, Brazil.

Rêgo WMF, Costa JGL, Baraviera RCA, Pinto LV, Bessa GL, Lopes REN, Vitor RWA.

Vet Parasitol. 2017 Nov 30;247:19-25. doi: 10.1016/j.vetpar.2017.09.015. Epub 2017 Sep 22.

PMID:
29080759
10.

Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.

Fox BA, Sanders KL, Rommereim LM, Guevara RB, Bzik DJ.

PLoS Genet. 2016 Jul 22;12(7):e1006189. doi: 10.1371/journal.pgen.1006189. eCollection 2016 Jul.

11.

The ROP18 and ROP5 gene allele types are highly predictive of virulence in mice across globally distributed strains of Toxoplasma gondii.

Shwab EK, Jiang T, Pena HF, Gennari SM, Dubey JP, Su C.

Int J Parasitol. 2016 Feb;46(2):141-6. doi: 10.1016/j.ijpara.2015.10.005. Epub 2015 Dec 14.

PMID:
26699401
12.

The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.

Hermanns T, Müller UB, Könen-Waisman S, Howard JC, Steinfeldt T.

Cell Microbiol. 2016 Feb;18(2):244-59. doi: 10.1111/cmi.12499. Epub 2015 Oct 30.

13.

Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.

Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD.

Cell Host Microbe. 2010 Dec 16;8(6):484-95. doi: 10.1016/j.chom.2010.11.005.

14.

The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.

Reese ML, Shah N, Boothroyd JC.

J Biol Chem. 2014 Oct 3;289(40):27849-58. doi: 10.1074/jbc.M114.567057. Epub 2014 Aug 12.

15.

Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.

Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC.

PLoS Biol. 2010 Dec 21;8(12):e1000576. doi: 10.1371/journal.pbio.1000576. Erratum in: PLoS Biol. 2015 Jul;13(7):e1002199.

16.

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.

Behnke MS, Khan A, Lauron EJ, Jimah JR, Wang Q, Tolia NH, Sibley LD.

PLoS Genet. 2015 Aug 20;11(8):e1005434. doi: 10.1371/journal.pgen.1005434. eCollection 2015 Aug.

17.

Towards vaccine against toxoplasmosis: evaluation of the immunogenic and protective activity of recombinant ROP5 and ROP18 Toxoplasma gondii proteins.

Grzybowski MM, Dziadek B, Gatkowska JM, Dzitko K, Długońska H.

Parasitol Res. 2015 Dec;114(12):4553-63. doi: 10.1007/s00436-015-4701-y. Epub 2015 Sep 4.

PMID:
26337271
18.

Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18.

Yamamoto M, Takeda K.

Virulence. 2012 Jan-Feb;3(1):77-80. doi: 10.4161/viru.3.1.18340. Epub 2012 Jan 1.

PMID:
22286708
19.

The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii.

Fentress SJ, Steinfeldt T, Howard JC, Sibley LD.

Cell Microbiol. 2012 Dec;14(12):1921-33. doi: 10.1111/cmi.12022. Epub 2012 Sep 20.

20.

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases.

Behnke MS, Khan A, Wootton JC, Dubey JP, Tang K, Sibley LD.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9631-6. doi: 10.1073/pnas.1015338108. Epub 2011 May 17.

Supplemental Content

Support Center