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Items: 1 to 20 of 125

1.

Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.

Wijnker PJ, Foster DB, Tsao AL, Frazier AH, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H260-8. doi: 10.1152/ajpheart.00498.2012. Epub 2012 Nov 9.

2.

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

Wijnker PJ, Sequeira V, Foster DB, Li Y, Dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1171-81. doi: 10.1152/ajpheart.00580.2013. Epub 2014 Feb 28.

3.

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

Wijnker PJ, Sequeira V, Witjas-Paalberends ER, Foster DB, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J.

Arch Biochem Biophys. 2014 Jul 15;554:11-21. doi: 10.1016/j.abb.2014.04.017. Epub 2014 May 9.

4.

PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils.

Rao V, Cheng Y, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M.

Biophys J. 2014 Sep 2;107(5):1196-204. doi: 10.1016/j.bpj.2014.07.027.

5.

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

Kooij V, Zhang P, Piersma SR, Sequeira V, Boontje NM, Wijnker PJ, Jiménez CR, Jaquet KE, dos Remedios C, Murphy AM, Van Eyk JE, van der Velden J, Stienen GJ.

PLoS One. 2013 Oct 7;8(10):e74847. doi: 10.1371/journal.pone.0074847. eCollection 2013 Oct 7.

6.

Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function.

Haworth RS, Cuello F, Herron TJ, Franzen G, Kentish JC, Gautel M, Avkiran M.

Circ Res. 2004 Nov 26;95(11):1091-9. Epub 2004 Oct 28.

7.

The unique amino-terminal peptide of cardiac troponin I regulates myofibrillar activity only when it is phosphorylated.

Wattanapermpool J, Guo X, Solaro RJ.

J Mol Cell Cardiol. 1995 Jul;27(7):1383-91.

PMID:
7473784
8.

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.

Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J.

J Mol Cell Cardiol. 2015 May;82:93-103. doi: 10.1016/j.yjmcc.2015.03.006. Epub 2015 Mar 11.

9.

Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation.

Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M.

J Biol Chem. 2015 Nov 13;290(46):27749-66. doi: 10.1074/jbc.M115.683045. Epub 2015 Sep 21.

10.

Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle.

Narolska NA, Piroddi N, Belus A, Boontje NM, Scellini B, Deppermann S, Zaremba R, Musters RJ, dos Remedios C, Jaquet K, Foster DB, Murphy AM, van Eyk JE, Tesi C, Poggesi C, van der Velden J, Stienen GJ.

Circ Res. 2006 Oct 27;99(9):1012-20. Epub 2006 Oct 5.

11.

Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background.

Kooij V, Saes M, Jaquet K, Zaremba R, Foster DB, Murphy AM, Dos Remedios C, van der Velden J, Stienen GJ.

J Mol Cell Cardiol. 2010 May;48(5):954-63. doi: 10.1016/j.yjmcc.2010.01.002. Epub 2010 Jan 15.

12.

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.

Rao VS, Korte FS, Razumova MV, Feest ER, Hsu H, Irving TC, Regnier M, Martyn DA.

J Physiol. 2013 Jan 15;591(2):475-90. doi: 10.1113/jphysiol.2012.241604. Epub 2012 Nov 5.

13.

AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.

Nixon BR, Thawornkaiwong A, Jin J, Brundage EA, Little SC, Davis JP, Solaro RJ, Biesiadecki BJ.

J Biol Chem. 2012 Jun 1;287(23):19136-47. doi: 10.1074/jbc.M111.323048. Epub 2012 Apr 6.

14.

Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation.

Kumar M, Govindan S, Zhang M, Khairallah RJ, Martin JL, Sadayappan S, de Tombe PP.

J Biol Chem. 2015 Dec 4;290(49):29241-9. doi: 10.1074/jbc.M115.686790. Epub 2015 Oct 9.

15.

Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling.

Bardswell SC, Cuello F, Rowland AJ, Sadayappan S, Robbins J, Gautel M, Walker JW, Kentish JC, Avkiran M.

J Biol Chem. 2010 Feb 19;285(8):5674-82. doi: 10.1074/jbc.M109.066456. Epub 2009 Dec 17.

16.

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium.

Pi Y, Zhang D, Kemnitz KR, Wang H, Walker JW.

J Physiol. 2003 Nov 1;552(Pt 3):845-57. Epub 2003 Aug 15.

17.
18.

Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.

Parvatiyar MS, Pinto JR.

Biochim Biophys Acta. 2015 Feb;1850(2):365-72. doi: 10.1016/j.bbagen.2014.09.029. Epub 2014 Nov 1.

19.

Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.

Wang Y, Pinto JR, Solis RS, Dweck D, Liang J, Diaz-Perez Z, Ge Y, Walker JW, Potter JD.

J Biol Chem. 2012 Jan 13;287(3):2156-67. doi: 10.1074/jbc.M111.294306. Epub 2011 Nov 15.

20.

The influence of trout cardiac troponin I and PKA phosphorylation on the Ca2+ affinity of the cardiac troponin complex.

Kirkpatrick KP, Robertson AS, Klaiman JM, Gillis TE.

J Exp Biol. 2011 Jun 15;214(Pt 12):1981-8. doi: 10.1242/jeb.052860.

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