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Items: 1 to 20 of 96


Obesity in mice with adipocyte-specific deletion of clock component Arntl.

Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA.

Nat Med. 2012 Dec;18(12):1768-77. doi: 10.1038/nm.2979. Epub 2012 Nov 11.


Metabolic jet lag when the fat clock is out of sync.

Asterholm IW, Scherer PE.

Nat Med. 2012 Dec;18(12):1738-40. doi: 10.1038/nm.3010. No abstract available.


Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons.

Fick LJ, Fick GH, Belsham DD.

Biochem Biophys Res Commun. 2011 Sep 30;413(3):414-9. doi: 10.1016/j.bbrc.2011.08.103. Epub 2011 Aug 27.


Obesity and metabolic syndrome in circadian Clock mutant mice.

Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J.

Science. 2005 May 13;308(5724):1043-5. Epub 2005 Apr 21.


Layer and broiler chicks exhibit similar hypothalamic expression of orexigenic neuropeptides but distinct expression of genes related to energy homeostasis and obesity.

Yuan L, Ni Y, Barth S, Wang Y, Grossmann R, Zhao R.

Brain Res. 2009 Jun 1;1273:18-28. doi: 10.1016/j.brainres.2009.03.052. Epub 2009 Apr 1.


The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways.

Nam D, Guo B, Chatterjee S, Chen MH, Nelson D, Yechoor VK, Ma K.

J Cell Sci. 2015 May 1;128(9):1835-47. doi: 10.1242/jcs.167643. Epub 2015 Mar 6.


Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes.

Tong X, Zhang D, Arthurs B, Li P, Durudogan L, Gupta N, Yin L.

PLoS One. 2015 Jun 15;10(6):e0130047. doi: 10.1371/journal.pone.0130047. eCollection 2015.


Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.

Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ.

Nat Struct Mol Biol. 2015 Oct;22(10):759-66. doi: 10.1038/nsmb.3076. Epub 2015 Aug 31.


Shifting the circadian rhythm of feeding in mice induces gastrointestinal, metabolic and immune alterations which are influenced by ghrelin and the core clock gene Bmal1.

Laermans J, Broers C, Beckers K, Vancleef L, Steensels S, Thijs T, Tack J, Depoortere I.

PLoS One. 2014 Oct 16;9(10):e110176. doi: 10.1371/journal.pone.0110176. eCollection 2014.


Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation.

Shimba S, Ogawa T, Hitosugi S, Ichihashi Y, Nakadaira Y, Kobayashi M, Tezuka M, Kosuge Y, Ishige K, Ito Y, Komiyama K, Okamatsu-Ogura Y, Kimura K, Saito M.

PLoS One. 2011;6(9):e25231. doi: 10.1371/journal.pone.0025231. Epub 2011 Sep 22.


Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides.

Bullen JW Jr, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E662-70.


The melanocortin-3 receptor is required for entrainment to meal intake.

Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA.

J Neurosci. 2008 Nov 26;28(48):12946-55. doi: 10.1523/JNEUROSCI.3615-08.2008.


Differential effects of omega-3 fatty acid docosahexaenoic acid and palmitate on the circadian transcriptional profile of clock genes in immortalized hypothalamic neurons.

Greco JA, Oosterman JE, Belsham DD.

Am J Physiol Regul Integr Comp Physiol. 2014 Oct 15;307(8):R1049-60. doi: 10.1152/ajpregu.00100.2014. Epub 2014 Aug 20.


Circadian Rhythms in Diet-Induced Obesity.

Engin A.

Adv Exp Med Biol. 2017;960:19-52. doi: 10.1007/978-3-319-48382-5_2. Review.


Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis.

Shimba S, Ishii N, Ohta Y, Ohno T, Watabe Y, Hayashi M, Wada T, Aoyagi T, Tezuka M.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12071-6. Epub 2005 Aug 10.


Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.

Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.

Nature. 2010 Jul 29;466(7306):627-31. doi: 10.1038/nature09253.


The RelB subunit of NFκB acts as a negative regulator of circadian gene expression.

Bellet MM, Zocchi L, Sassone-Corsi P.

Cell Cycle. 2012 Sep 1;11(17):3304-11. doi: 10.4161/cc.21669. Epub 2012 Aug 16.


A metabolomic study of adipose tissue in mice with a disruption of the circadian system.

Castro C, Briggs W, Paschos GK, FitzGerald GA, Griffin JL.

Mol Biosyst. 2015 Jul;11(7):1897-906. doi: 10.1039/c5mb00032g.


p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

Baeza-Raja B, Eckel-Mahan K, Zhang L, Vagena E, Tsigelny IF, Sassone-Corsi P, Ptácek LJ, Akassoglou K.

J Neurosci. 2013 Jun 19;33(25):10221-34. doi: 10.1523/JNEUROSCI.2757-12.2013.


Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice.

Rakshit K, Hsu TW, Matveyenko AV.

Diabetologia. 2016 Apr;59(4):734-43. doi: 10.1007/s00125-015-3859-2. Epub 2016 Jan 13.

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