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Items: 1 to 20 of 95

1.

Atom-based enumeration: new eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux.

Yu MJ, Zheng W, Tendyke K.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7363-6. doi: 10.1016/j.bmcl.2012.10.077. Epub 2012 Oct 22.

PMID:
23141916
2.

Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility.

Narayan S, Carlson EM, Cheng H, Du H, Hu Y, Jiang Y, Lewis BM, Seletsky BM, Tendyke K, Zhang H, Zheng W, Littlefield BA, Towle MJ, Yu MJ.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1630-3. doi: 10.1016/j.bmcl.2011.01.111. Epub 2011 Jan 31.

PMID:
21324686
3.

Synthesis and antitumour activity of new muricatacin and goniofufurone analogues.

Popsavin V, Srećo B, Krstić I, Popsavin M, Kojić V, Bogdanović G.

Eur J Med Chem. 2006 Oct;41(10):1217-22. Epub 2006 Aug 7.

PMID:
16891043
4.

Macrocyclic ketone analogues of halichondrin B.

Zheng W, Seletsky BM, Palme MH, Lydon PJ, Singer LA, Chase CE, Lemelin CA, Shen Y, Davis H, Tremblay L, Towle MJ, Salvato KA, Wels BF, Aalfs KK, Kishi Y, Littlefield BA, Yu MJ.

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5551-4.

PMID:
15482922
5.

Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent.

Srivastava V, Negi AS, Kumar JK, Faridi U, Sisodia BS, Darokar MP, Luqman S, Khanuja SP.

Bioorg Med Chem Lett. 2006 Feb 15;16(4):911-4. Epub 2005 Nov 15.

PMID:
16297622
6.

The halichondrins and E7389.

Jackson KL, Henderson JA, Phillips AJ.

Chem Rev. 2009 Jul;109(7):3044-79. doi: 10.1021/cr900016w. Review. No abstract available.

PMID:
19534494
7.

Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4.

Zhang ZY, King BM, Pelletier RD, Wong YN.

Cancer Chemother Pharmacol. 2008 Sep;62(4):707-16. doi: 10.1007/s00280-008-0755-1. Epub 2008 Apr 23.

PMID:
18431572
8.

Macromolecular interaction of halichondrin B analogues eribulin (E7389) and ER-076349 with tubulin by analytical ultracentrifugation.

Alday PH, Correia JJ.

Biochemistry. 2009 Aug 25;48(33):7927-38. doi: 10.1021/bi900776u.

PMID:
19586046
9.

Chemistry. The renaissance of natural products as drug candidates.

Paterson I, Anderson EA.

Science. 2005 Oct 21;310(5747):451-3. No abstract available.

PMID:
16239465
10.

2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents.

Singh P, Mittal A, Kaur S, Holzer W, Kumar S.

Org Biomol Chem. 2008 Aug 7;6(15):2706-12. doi: 10.1039/b803608j. Epub 2008 May 22.

PMID:
18633528
11.

Synthesis and primary cytotoxicity evaluation of arylmethylenenaphthofuranones derivatives.

Lardic M, Patry C, Duflos M, Guillon J, Massip S, Cruzalegui F, Edmonds T, Giraudet S, Marini L, Leonce S.

J Enzyme Inhib Med Chem. 2006 Jun;21(3):313-25.

PMID:
16918079
12.

The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines.

Wang F, Liu Z, Wang J, Tao J, Gong P, Bao X, Zhao Y, Wang Y.

Eur J Med Chem. 2015 Aug 28;101:126-32. doi: 10.1016/j.ejmech.2015.06.002. Epub 2015 Jun 5.

PMID:
26123642
13.

Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors.

Zhang J, Cao J, Xu L, Zhou Y, Liu T, Li J, Hu Y.

Bioorg Med Chem. 2014 Jun 1;22(11):2955-65. doi: 10.1016/j.bmc.2014.04.011. Epub 2014 Apr 13.

PMID:
24767818
14.

Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.

Qiu X, Liu Z, Shao WY, Liu X, Jing DP, Yu YJ, An LK, Huang SL, Bu XZ, Huang ZS, Gu LQ.

Bioorg Med Chem. 2008 Sep 1;16(17):8035-41. doi: 10.1016/j.bmc.2008.07.054. Epub 2008 Jul 24.

PMID:
18678491
15.

Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives.

Nakagawa-Goto K, Wu JH, Bastow KF, Wu CC, Lee KH.

Bioorg Med Chem. 2005 Mar 15;13(6):2325-30.

PMID:
15727881
16.

Design, synthesis and antiproliferative activity of two new heteroannelated (-)-muricatacin mimics.

Popsavin V, Srećo B, Benedeković G, Popsavin M, Francuz J, Kojić V, Bogdanović G.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5182-5. doi: 10.1016/j.bmcl.2008.08.097. Epub 2008 Aug 29.

PMID:
18790637
17.

Cytotoxic simplified tubulysin analogues.

Raghavan B, Balasubramanian R, Steele JC, Sackett DL, Fecik RA.

J Med Chem. 2008 Mar 27;51(6):1530-3. doi: 10.1021/jm701321p. Epub 2008 Mar 4.

PMID:
18314944
18.

Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones.

Kim Y, Nam NH, You YJ, Ahn BZ.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):719-22.

PMID:
11844709
19.

Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.

Kudou N, Taniguchi A, Sugimoto K, Matsuya Y, Kawasaki M, Toyooka N, Miyoshi C, Awale S, Dibwe DF, Esumi H, Kadota S, Tezuka Y.

Eur J Med Chem. 2013 Feb;60:76-88. doi: 10.1016/j.ejmech.2012.11.031. Epub 2012 Nov 28.

PMID:
23287053
20.

Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo.

Narayan S, Carlson EM, Cheng H, Condon K, Du H, Eckley S, Hu Y, Jiang Y, Kumar V, Lewis BM, Saxton P, Schuck E, Seletsky BM, Tendyke K, Zhang H, Zheng W, Littlefield BA, Towle MJ, Yu MJ.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1634-8. doi: 10.1016/j.bmcl.2011.01.097. Epub 2011 Jan 25.

PMID:
21324692

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