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Items: 1 to 20 of 106

1.

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.

Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH.

Cell Metab. 2012 Nov 7;16(5):625-33. doi: 10.1016/j.cmet.2012.10.009.

2.

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.

Andersson SA, Olsson AH, Esguerra JL, Heimann E, Ladenvall C, Edlund A, Salehi A, Taneera J, Degerman E, Groop L, Ling C, Eliasson L.

Mol Cell Endocrinol. 2012 Nov 25;364(1-2):36-45. doi: 10.1016/j.mce.2012.08.009. Epub 2012 Aug 23.

3.

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.

Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH.

Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652.

4.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.

5.

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Park YJ, Warnock GL, Ao Z, Safikhan N, Meloche M, Asadi A, Kieffer TJ, Marzban L.

Diabetes Obes Metab. 2017 May;19(5):682-694. doi: 10.1111/dom.12873. Epub 2017 Feb 27.

PMID:
28058779
6.

Relationship between serum secreted frizzled-related protein 4 levels and the first-phase of glucose-stimulated insulin secretion in individuals with different glucose tolerance.

Liu F, Qu H, Li Y, Tang Q, Yang Z, Wang H, Deng H.

Endocr J. 2015;62(8):733-40. doi: 10.1507/endocrj.EJ15-0212. Epub 2015 Jul 4.

7.

Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.

Taneera J, Fadista J, Ahlqvist E, Atac D, Ottosson-Laakso E, Wollheim CB, Groop L.

Hum Mol Genet. 2015 Apr 1;24(7):1945-55. doi: 10.1093/hmg/ddu610. Epub 2014 Dec 8.

PMID:
25489054
8.

Thrombin stimulates insulin secretion via protease-activated receptor-3.

Hänzelmann S, Wang J, Güney E, Tang Y, Zhang E, Axelsson AS, Nenonen H, Salehi AS, Wollheim CB, Zetterberg E, Berntorp E, Costa IG, Castelo R, Rosengren AH.

Islets. 2015;7(4):e1118195. doi: 10.1080/19382014.2015.1118195.

9.

Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis.

Volkov P, Bacos K, Ofori JK, Esguerra JL, Eliasson L, Rönn T, Ling C.

Diabetes. 2017 Apr;66(4):1074-1085. doi: 10.2337/db16-0996. Epub 2017 Jan 4.

10.

Ca2+-secretion coupling is impaired in diabetic Goto Kakizaki rats.

Rose T, Efendic S, Rupnik M.

J Gen Physiol. 2007 Jun;129(6):493-508.

11.

Lupinus mutabilis Extract Exerts an Anti-Diabetic Effect by Improving Insulin Release in Type 2 Diabetic Goto-Kakizaki Rats.

Zambrana S, Lundqvist LCE, Mamani O, Catrina SB, Gonzales E, Östenson CG.

Nutrients. 2018 Jul 20;10(7). pii: E933. doi: 10.3390/nu10070933.

12.

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N.

Diabetologia. 2016 Sep;59(9):1928-37. doi: 10.1007/s00125-016-4020-6. Epub 2016 Jun 23.

PMID:
27338624
13.

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.

Dayeh T, Volkov P, Salö S, Hall E, Nilsson E, Olsson AH, Kirkpatrick CL, Wollheim CB, Eliasson L, Rönn T, Bacos K, Ling C.

PLoS Genet. 2014 Mar 6;10(3):e1004160. doi: 10.1371/journal.pgen.1004160. eCollection 2014 Mar.

14.

CaV2.3 calcium channels control second-phase insulin release.

Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renström E.

J Clin Invest. 2005 Jan;115(1):146-54.

15.

Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.

Bennet H, Balhuizen A, Medina A, Dekker Nitert M, Ottosson Laakso E, Essén S, Spégel P, Storm P, Krus U, Wierup N, Fex M.

Peptides. 2015 Sep;71:113-20. doi: 10.1016/j.peptides.2015.07.008. Epub 2015 Jul 20.

PMID:
26206285
16.

Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol.

Nagaraj V, Kazim AS, Helgeson J, Lewold C, Barik S, Buda P, Reinbothe TM, Wennmalm S, Zhang E, Renström E.

Mol Endocrinol. 2016 Oct;30(10):1059-1069. Epub 2016 Aug 17.

17.

Androgen receptor-deficient islet β-cells exhibit alteration in genetic markers of insulin secretion and inflammation. A transcriptome analysis in the male mouse.

Xu W, Niu T, Xu B, Navarro G, Schipma MJ, Mauvais-Jarvis F.

J Diabetes Complications. 2017 May;31(5):787-795. doi: 10.1016/j.jdiacomp.2017.03.002. Epub 2017 Mar 9.

18.
19.

IL-1β hampers glucose-stimulated insulin secretion in Cohen diabetic rat islets through mitochondrial cytochrome c oxidase inhibition by nitric oxide.

Weksler-Zangen S, Aharon-Hananel G, Mantzur C, Aouizerat T, Gurgul-Convey E, Raz I, Saada A.

Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E648-57. doi: 10.1152/ajpendo.00451.2013. Epub 2014 Jan 14.

20.

Secreted Frizzled-Related Protein 4 (SFRP4) is Elevated in Patients with Diabetes Mellitus.

Brix JM, Krzizek EC, Hoebaus C, Ludvik B, Schernthaner G, Schernthaner GH.

Horm Metab Res. 2016 May;48(5):345-8. doi: 10.1055/s-0041-111698. Epub 2016 Feb 16.

PMID:
26882051

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