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Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1.

Prabhakar S, Taherian M, Gianni D, Conlon TJ, Fulci G, Brockmann J, Stemmer-Rachamimov A, Sena-Esteves M, Breakefield XO, Brenner GJ.

Hum Gene Ther. 2013 Feb;24(2):152-62. doi: 10.1089/hum.2012.094. Epub 2013 Jan 30.


Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter.

Prabhakar S, Brenner GJ, Sung B, Messerli SM, Mao J, Sena-Esteves M, Stemmer-Rachamimov A, Tannous B, Breakefield XO.

Cancer Gene Ther. 2010 Apr;17(4):266-74. doi: 10.1038/cgt.2009.71. Epub 2009 Oct 16.


Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2.

Messerli SM, Prabhakar S, Tang Y, Mahmood U, Giovannini M, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO.

Hum Gene Ther. 2006 Jan;17(1):20-30. Erratum in: Hum Gene Ther. 2006 Jul;17(7):796. Giovannini, Marco [added].


Suppression of cancer growth in mice by adeno-associated virus vector-mediated IFN-beta expression driven by hTERT promoter.

He LF, Wang YG, Xiao T, Zhang KJ, Li GC, Gu JF, Chu L, Tang WH, Tan WS, Liu XY.

Cancer Lett. 2009 Dec 28;286(2):196-205. doi: 10.1016/j.canlet.2009.05.024. Epub 2009 Jun 28.


Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta.

Prabhakar S, Messerli SM, Stemmer-Rachamimov AO, Liu TC, Rabkin S, Martuza R, Breakefield XO.

Cancer Gene Ther. 2007 May;14(5):460-7. Epub 2007 Feb 16.


A novel imaging-compatible sciatic nerve schwannoma model.

Saydam O, Ozdener GB, Senol O, Mizrak A, Prabhakar S, Stemmer-Rachamimov AO, Breakefield XO, Brenner GJ.

J Neurosci Methods. 2011 Jan 30;195(1):75-7. doi: 10.1016/j.jneumeth.2010.10.021. Epub 2010 Nov 24.


Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck squamous cell carcinoma.

Jiang M, Liu Z, Xiang Y, Ma H, Liu S, Liu Y, Zheng D.

BMC Cancer. 2011 Feb 3;11:54. doi: 10.1186/1471-2407-11-54.


Clinical features of spinal schwannomas in 65 patients with schwannomatosis compared with 831 with solitary schwannomas and 102 with neurofibromatosis Type 2: a retrospective study at a single institution.

Li P, Zhao F, Zhang J, Wang Z, Wang X, Wang B, Yang Z, Yang J, Gao Z, Liu P.

J Neurosurg Spine. 2016 Jan;24(1):145-54. doi: 10.3171/2015.3.SPINE141145. Epub 2015 Sep 25.


Adeno-associated virus 2-mediated intratumoral prostate cancer gene therapy: long-term maspin expression efficiently suppresses tumor growth.

Watanabe M, Nasu Y, Kashiwakura Y, Kusumi N, Tamayose K, Nagai A, Sasano T, Shimada T, Daida H, Kumon H.

Hum Gene Ther. 2005 Jun;16(6):699-710.


An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer.

Chtarto A, Bockstael O, Gebara E, Vermoesen K, Melas C, Pythoud C, Levivier M, De Witte O, Luthi-Carter R, Clinkers R, Tenenbaum L.

PLoS One. 2013;8(1):e53156. doi: 10.1371/journal.pone.0053156. Epub 2013 Jan 3.


Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.

Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KM, Kirschner LS.

Oncogene. 2013 Jul 25;32(30):3491-9. doi: 10.1038/onc.2012.374. Epub 2012 Oct 8.


Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential.

Li Q, Miller R, Han PY, Pang J, Dinculescu A, Chiodo V, Hauswirth WW.

Mol Vis. 2008 Sep 24;14:1760-9.


Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse.

Lee JK, Sobel RA, Chiocca EA, Kim TS, Martuza RL.

J Neurooncol. 1992 Oct;14(2):101-12.


Glial promoter selectivity following AAV-delivery to the immature brain.

von Jonquieres G, Mersmann N, Klugmann CB, Harasta AE, Lutz B, Teahan O, Housley GD, Fröhlich D, Krämer-Albers EM, Klugmann M.

PLoS One. 2013 Jun 14;8(6):e65646. doi: 10.1371/journal.pone.0065646. Print 2013.


Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery.

Towne C, Pertin M, Beggah AT, Aebischer P, Decosterd I.

Mol Pain. 2009 Sep 8;5:52. doi: 10.1186/1744-8069-5-52.


A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation.

Gehlhausen JR, Park SJ, Hickox AE, Shew M, Staser K, Rhodes SD, Menon K, Lajiness JD, Mwanthi M, Yang X, Yuan J, Territo P, Hutchins G, Nalepa G, Yang FC, Conway SJ, Heinz MG, Stemmer-Rachamimov A, Yates CW, Wade Clapp D.

Hum Mol Genet. 2015 Jan 1;24(1):1-8. doi: 10.1093/hmg/ddu414. Epub 2014 Aug 11.


Adeno-associated virus-mediated local delivery of LIGHT suppresses tumorigenesis in a murine cervical cancer model.

Maitituoheti M, Li Y, Wang W, Wang W, Han L, Yang R, Wang T, Wu Z, Ma D, Wang S.

J Immunother. 2011 Oct;34(8):581-7. doi: 10.1097/CJI.0b013e31822b9fe0.


Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2.

Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO.

Neoplasia. 2002 Nov-Dec;4(6):501-9.


Immortalized Human Schwann Cell Lines Derived From Tumors of Schwannomatosis Patients.

Ostrow KL, Donaldson K, Blakeley J, Belzberg A, Hoke A.

PLoS One. 2015 Dec 14;10(12):e0144620. doi: 10.1371/journal.pone.0144620. eCollection 2015.


The human rhodopsin kinase promoter in an AAV5 vector confers rod- and cone-specific expression in the primate retina.

Boye SE, Alexander JJ, Boye SL, Witherspoon CD, Sandefer KJ, Conlon TJ, Erger K, Sun J, Ryals R, Chiodo VA, Clark ME, Girkin CA, Hauswirth WW, Gamlin PD.

Hum Gene Ther. 2012 Oct;23(10):1101-15. doi: 10.1089/hum.2012.125. Epub 2012 Sep 20.

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