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Items: 1 to 20 of 98

1.

Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Lerman BJ, Hoffman EP, Sutherland ML, Bouri K, Hsu DK, Liu FT, Rothstein JD, Knoblach SM.

Brain Behav. 2012 Sep;2(5):563-75. doi: 10.1002/brb3.75. Epub 2012 Jul 23.

2.

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats.

Nikodemova M, Small AL, Smith SM, Mitchell GS, Watters JJ.

Neurobiol Dis. 2014 Sep;69:43-53. doi: 10.1016/j.nbd.2013.11.009. Epub 2013 Nov 19.

3.

Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis.

Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K.

Am J Pathol. 2015 Nov;185(11):3053-65. doi: 10.1016/j.ajpath.2015.07.016. Epub 2015 Sep 9.

PMID:
26362733
4.

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice.

Bartlett R, Sluyter V, Watson D, Sluyter R, Yerbury JJ.

PeerJ. 2017 Mar 1;5:e3064. doi: 10.7717/peerj.3064. eCollection 2017.

5.

Expression of heat shock transcription factor 1 and its downstream target protein T-cell death associated gene 51 in the spinal cord of a mouse model of amyotrophic lateral sclerosis.

Mimoto T, Morimoto N, Miyazaki K, Kurata T, Sato K, Ikeda Y, Abe K.

Brain Res. 2012 Dec 7;1488:123-31. doi: 10.1016/j.brainres.2012.10.012. Epub 2012 Oct 11.

PMID:
23063459
6.

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis.

Zhang X, Chen S, Song L, Tang Y, Shen Y, Jia L, Le W.

Autophagy. 2014 Apr;10(4):588-602. doi: 10.4161/auto.27710. Epub 2014 Jan 15.

7.

Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis.

Andrus PK, Fleck TJ, Gurney ME, Hall ED.

J Neurochem. 1998 Nov;71(5):2041-8.

8.

Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: a longitudinal MRI study.

Marcuzzo S, Zucca I, Mastropietro A, de Rosbo NK, Cavalcante P, Tartari S, Bonanno S, Preite L, Mantegazza R, Bernasconi P.

Exp Neurol. 2011 Sep;231(1):30-7. doi: 10.1016/j.expneurol.2011.05.007. Epub 2011 May 14.

PMID:
21620832
9.

Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis.

Yoo YE, Ko CP.

Exp Neurol. 2011 Sep;231(1):147-59. doi: 10.1016/j.expneurol.2011.06.003. Epub 2011 Jun 25.

PMID:
21712032
10.

Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.

Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, Jaquet V.

Free Radic Biol Med. 2016 Aug;97:95-108. doi: 10.1016/j.freeradbiomed.2016.05.016. Epub 2016 May 19.

11.

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression.

Apolloni S, Fabbrizio P, Amadio S, Volonté C.

J Neuroinflammation. 2016 Aug 22;13(1):191. doi: 10.1186/s12974-016-0658-8.

12.

Apoptosis-inducing factor and cyclophilin A cotranslocate to the motor neuronal nuclei in amyotrophic lateral sclerosis model mice.

Tanaka H, Shimazaki H, Kimura M, Izuta H, Tsuruma K, Shimazawa M, Hara H.

CNS Neurosci Ther. 2011 Oct;17(5):294-304. doi: 10.1111/j.1755-5949.2010.00180.x. Epub 2010 Jun 14.

PMID:
20553309
13.

Caspase 6 has a protective role in SOD1(G93A) transgenic mice.

Hogg MC, Mitchem MR, König HG, Prehn JH.

Biochim Biophys Acta. 2016 Jun;1862(6):1063-73. doi: 10.1016/j.bbadis.2016.03.006. Epub 2016 Mar 11.

PMID:
26976329
14.

Lack of TNF-alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression.

Tortarolo M, Vallarola A, Lidonnici D, Battaglia E, Gensano F, Spaltro G, Fiordaliso F, Corbelli A, Garetto S, Martini E, Pasetto L, Kallikourdis M, Bonetto V, Bendotti C.

J Neurochem. 2015 Oct;135(1):109-24. doi: 10.1111/jnc.13154. Epub 2015 Jun 4.

15.

Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model.

Luo G, Yi J, Ma C, Xiao Y, Yi F, Yu T, Zhou J.

PLoS One. 2013 Dec 6;8(12):e82112. doi: 10.1371/journal.pone.0082112. eCollection 2013.

16.

Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model.

Sunyach C, Michaud M, Arnoux T, Bernard-Marissal N, Aebischer J, Latyszenok V, Gouarné C, Raoul C, Pruss RM, Bordet T, Pettmann B.

Neuropharmacology. 2012 Jun;62(7):2346-52. doi: 10.1016/j.neuropharm.2012.02.013. Epub 2012 Feb 20.

PMID:
22369784
17.
18.

Caffeic acid phenethyl ester extends survival of a mouse model of amyotrophic lateral sclerosis.

Fontanilla CV, Wei X, Zhao L, Johnstone B, Pascuzzi RM, Farlow MR, Du Y.

Neuroscience. 2012 Mar 15;205:185-93. doi: 10.1016/j.neuroscience.2011.12.025. Epub 2011 Dec 24.

PMID:
22206942
19.

Therapeutic effects of dl-3-n-butylphthalide in a transgenic mouse model of amyotrophic lateral sclerosis.

Feng XH, Yuan W, Peng Y, Liu MS, Cui LY.

Chin Med J (Engl). 2012 May;125(10):1760-6.

PMID:
22800896
20.

Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis.

Kasai A, Kinjo T, Ishihara R, Sakai I, Ishimaru Y, Yoshioka Y, Yamamuro A, Ishige K, Ito Y, Maeda S.

PLoS One. 2011;6(8):e23968. doi: 10.1371/journal.pone.0023968. Epub 2011 Aug 24.

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