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Items: 1 to 20 of 112

1.

Correlates between host and viral transcriptional program associated with different oncolytic vaccinia virus isolates.

Reinboth J, Ascierto ML, Chen NG, Zhang Q, Yu YA, Aguilar RJ, Carretero R, Worschech A, Zhao Y, Wang E, Marincola FM, Szalay AA.

Hum Gene Ther Methods. 2012 Oct;23(5):285-96. doi: 10.1089/hgtb.2012.057. Epub 2012 Nov 6.

2.

Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice.

Chen NG, Yu YA, Zhang Q, Szalay AA.

J Transl Med. 2011 Sep 27;9:164. doi: 10.1186/1479-5876-9-164.

3.

Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68.

Ascierto ML, Worschech A, Yu Z, Adams S, Reinboth J, Chen NG, Pos Z, Roychoudhuri R, Di Pasquale G, Bedognetti D, Uccellini L, Rossano F, Ascierto PA, Stroncek DF, Restifo NP, Wang E, Szalay AA, Marincola FM.

BMC Cancer. 2011 Oct 19;11:451. doi: 10.1186/1471-2407-11-451.

4.

Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus.

Haddad D, Chen NG, Zhang Q, Chen CH, Yu YA, Gonzalez L, Carpenter SG, Carson J, Au J, Mittra A, Gonen M, Zanzonico PB, Fong Y, Szalay AA.

J Transl Med. 2011 Mar 31;9:36. doi: 10.1186/1479-5876-9-36.

5.

JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase.

Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B.

Cancer Gene Ther. 2008 Sep;15(9):616-24. doi: 10.1038/cgt.2008.32. Epub 2008 Jun 6.

6.

Viral-mediated oncolysis is the most critical factor in the late-phase of the tumor regression process upon vaccinia virus infection.

Weibel S, Raab V, Yu YA, Worschech A, Wang E, Marincola FM, Szalay AA.

BMC Cancer. 2011 Feb 14;11:68. doi: 10.1186/1471-2407-11-68.

7.

Growth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV-1h68.

Ehrig K, Kilinc MO, Chen NG, Stritzker J, Buckel L, Zhang Q, Szalay AA.

J Transl Med. 2013 Mar 26;11:79. doi: 10.1186/1479-5876-11-79.

8.

Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68.

Gentschev I, Müller M, Adelfinger M, Weibel S, Grummt F, Zimmermann M, Bitzer M, Heisig M, Zhang Q, Yu YA, Chen NG, Stritzker J, Lauer UM, Szalay AA.

PLoS One. 2011;6(7):e22069. doi: 10.1371/journal.pone.0022069. Epub 2011 Jul 11.

9.

A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference.

Beard PM, Griffiths SJ, Gonzalez O, Haga IR, Pechenick Jowers T, Reynolds DK, Wildenhain J, Tekotte H, Auer M, Tyers M, Ghazal P, Zimmer R, Haas J.

PLoS One. 2014 Jun 5;9(6):e98431. doi: 10.1371/journal.pone.0098431. eCollection 2014.

10.

Antibiotic-dependent expression of early transcription factor subunits leads to stringent control of vaccinia virus replication.

Hagen CJ, Titong A, Sarnoski EA, Verardi PH.

Virus Res. 2014 Mar 6;181:43-52. doi: 10.1016/j.virusres.2013.12.033. Epub 2014 Jan 3.

11.

Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma.

Gentschev I, Adelfinger M, Josupeit R, Rudolph S, Ehrig K, Donat U, Weibel S, Chen NG, Yu YA, Zhang Q, Heisig M, Thamm D, Stritzker J, Macneill A, Szalay AA.

PLoS One. 2012;7(5):e37239. doi: 10.1371/journal.pone.0037239. Epub 2012 May 15.

12.

Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps.

Kober C, Rohn S, Weibel S, Geissinger U, Chen NG, Szalay AA.

J Transl Med. 2015 Jul 7;13:216. doi: 10.1186/s12967-015-0586-x.

13.

Vaccinia virus-mediated intra-tumoral expression of matrix metalloproteinase 9 enhances oncolysis of PC-3 xenograft tumors.

Schäfer S, Weibel S, Donat U, Zhang Q, Aguilar RJ, Chen NG, Szalay AA.

BMC Cancer. 2012 Aug 23;12:366. doi: 10.1186/1471-2407-12-366.

14.

Regression of human prostate tumors and metastases in nude mice following treatment with the recombinant oncolytic vaccinia virus GLV-1h68.

Gentschev I, Donat U, Hofmann E, Weibel S, Adelfinger M, Raab V, Heisig M, Chen N, Yu YA, Stritzker J, Szalay AA.

J Biomed Biotechnol. 2010;2010:489759. doi: 10.1155/2010/489759. Epub 2010 Apr 1.

15.

Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus.

Zhang Q, Yu YA, Wang E, Chen N, Danner RL, Munson PJ, Marincola FM, Szalay AA.

Cancer Res. 2007 Oct 15;67(20):10038-46.

16.
17.

Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68.

Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA.

Mol Cancer Ther. 2009 Jan;8(1):141-51. doi: 10.1158/1535-7163.MCT-08-0533.

18.

Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis.

Dorer DE, Holtrup F, Fellenberg K, Kaufmann JK, Engelhardt S, Hoheisel JD, Nettelbeck DM.

PLoS One. 2011;6(11):e27934. doi: 10.1371/journal.pone.0027934. Epub 2011 Nov 30.

19.

A novel genetically modified oncolytic vaccinia virus in experimental models is effective against a wide range of human cancers.

Haddad D, Chen N, Zhang Q, Chen CH, Yu YA, Gonzalez L, Aguilar J, Li P, Wong J, Szalay AA, Fong Y.

Ann Surg Oncol. 2012 Jul;19 Suppl 3:S665-74. doi: 10.1245/s10434-011-2198-x. Epub 2012 Jan 19.

PMID:
22258815
20.

Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy.

Frentzen A, Yu YA, Chen N, Zhang Q, Weibel S, Raab V, Szalay AA.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12915-20. doi: 10.1073/pnas.0900660106. Epub 2009 Jul 15.

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