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Phosphorylation of Cdc6 at serine 74, but not at serine 106, drives translocation of Cdc6 to the cytoplasm.

Yim H, Park JW, Woo SU, Kim ST, Liu L, Lee CH, Lee SK.

J Cell Physiol. 2013 Jun;228(6):1221-8. doi: 10.1002/jcp.24275.


Two nuclear export signals of Cdc6 are differentially associated with CDK-mediated phosphorylation residues for cytoplasmic translocation.

Hwang IS, Woo SU, Park JW, Lee SK, Yim H.

Biochim Biophys Acta. 2014 Feb;1843(2):223-33. doi: 10.1016/j.bbamcr.2013.10.024. Epub 2013 Nov 8.


Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.

Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K.

EMBO J. 1999 Jan 15;18(2):396-410.


Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.

Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1347-52. Epub 2002 Jan 22.


Regulation of the localization and stability of Cdc6 in living yeast cells.

Luo KQ, Elsasser S, Chang DC, Campbell JL.

Biochem Biophys Res Commun. 2003 Jul 11;306(4):851-9.


Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells.

Lunn CL, Chrivia JC, Baldassare JJ.

Cell Cycle. 2010 Nov 15;9(22):4533-41. Epub 2010 Nov 15.


Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

Nguyen VQ, Co C, Irie K, Li JJ.

Curr Biol. 2000 Feb 24;10(4):195-205.


Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.

Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ.

Oncogene. 2004 Apr 8;23(15):2658-63.


Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm.

Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J.

Mol Biol Cell. 2002 Mar;13(3):1030-45.


Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.

Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa-Saito M, Waga S, Kiyono T, Fujita M.

J Cell Sci. 2009 Apr 15;122(Pt 8):1184-91. doi: 10.1242/jcs.041889.


A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.

Li C, Andrake M, Dunbrack R, Enders GH.

Mol Cell Biol. 2010 Jan;30(1):116-30. doi: 10.1128/MCB.01876-08.


HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.

Hall C, Nelson DM, Ye X, Baker K, DeCaprio JA, Seeholzer S, Lipinski M, Adams PD.

Mol Cell Biol. 2001 Mar;21(5):1854-65.


Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1.

Santaguida M, Nepveu A.

J Biol Chem. 2005 Sep 23;280(38):32712-21. Epub 2005 Aug 3.


Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization.

Bermejo R, Vilaboa N, Calés C.

Mol Biol Cell. 2002 Nov;13(11):3989-4000.


Intracellular localization of the cyclin-dependent kinase inhibitor p21CDKN1A-GFP fusion protein during cell cycle arrest.

Cazzalini O, Perucca P, Valsecchi F, Stivala LA, Bianchi L, Vannini V, Prosperi E.

Histochem Cell Biol. 2004 May;121(5):377-81. Epub 2004 May 7.


A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.

Lin R, Yang L, Arguello M, Penafuerte C, Hiscott J.

J Biol Chem. 2005 Jan 28;280(4):3088-95. Epub 2004 Nov 19.


Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.

Deng M, Li F, Ballif BA, Li S, Chen X, Guo L, Ye X.

J Biol Chem. 2009 Mar 20;284(12):7875-88. doi: 10.1074/jbc.M807827200. Epub 2009 Jan 16.


Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis.

Yim H, Jin YH, Park BD, Choi HJ, Lee SK.

Mol Biol Cell. 2003 Oct;14(10):4250-9. Epub 2003 Jun 27.


Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.

Lents NH, Keenan SM, Bellone C, Baldassare JJ.

J Biol Chem. 2002 Dec 6;277(49):47469-75. Epub 2002 Sep 30.

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