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Items: 1 to 20 of 336

1.

Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway.

Huang J, Huang K, Lan T, Xie X, Shen X, Liu P, Huang H.

Mol Cell Endocrinol. 2013 Jan 30;365(2):231-40. doi: 10.1016/j.mce.2012.10.024. Epub 2012 Nov 2.

PMID:
23127801
2.

AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose.

Huang K, Huang J, Chen C, Hao J, Wang S, Huang J, Liu P, Huang H.

Cell Signal. 2014 Mar;26(3):629-38. doi: 10.1016/j.cellsig.2013.12.002. Epub 2013 Dec 14.

PMID:
24342046
3.

Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway.

Chen C, Huang K, Hao J, Huang J, Yang Z, Xiong F, Liu P, Huang H.

Mol Cell Endocrinol. 2016 May 15;427:45-56. doi: 10.1016/j.mce.2016.03.003. Epub 2016 Mar 4.

PMID:
26948947
4.

Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells.

Lan T, Liu W, Xie X, Xu S, Huang K, Peng J, Shen X, Liu P, Wang L, Xia P, Huang H.

Mol Endocrinol. 2011 Dec;25(12):2094-105. doi: 10.1210/me.2011-0095. Epub 2011 Oct 13.

5.

Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway.

Lan T, Liu W, Xie X, Huang K, Peng J, Huang J, Shen X, Liu P, Yang H, Huang H.

Eur J Pharmacol. 2012 Dec 15;697(1-3):165-72. doi: 10.1016/j.ejphar.2012.10.003. Epub 2012 Oct 16.

PMID:
23085271
6.

TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells.

Yang Z, Xiong F, Wang Y, Gong W, Huang J, Chen C, Liu P, Huang H.

Pharmacol Res. 2016 Sep;111:226-236. doi: 10.1016/j.phrs.2016.05.035. Epub 2016 Jun 16.

PMID:
27317945
7.

Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling.

Xie X, Chang X, Chen L, Huang K, Huang J, Wang S, Shen X, Liu P, Huang H.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):56-65. doi: 10.1016/j.mce.2013.07.019. Epub 2013 Jul 26.

PMID:
23896433
8.

Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway.

Lan T, Shen X, Liu P, Liu W, Xu S, Xie X, Jiang Q, Li W, Huang H.

Arch Biochem Biophys. 2010 Oct 15;502(2):112-20. doi: 10.1016/j.abb.2010.07.012. Epub 2010 Jul 18.

PMID:
20646989
9.

Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy.

Deng Y, Lan T, Huang J, Huang H.

Chin Med J (Engl). 2014;127(16):3004-10. Review.

PMID:
25131242
10.

Berberine attenuates high glucose-induced fibrosis by activating the G protein-coupled bile acid receptor TGR5 and repressing the S1P2/MAPK signaling pathway in glomerular mesangial cells.

Yang Z, Li J, Xiong F, Huang J, Chen C, Liu P, Huang H.

Exp Cell Res. 2016 Aug 15;346(2):241-7. doi: 10.1016/j.yexcr.2016.06.005. Epub 2016 Jun 9.

PMID:
27292312
11.

Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models.

Huang K, Liu W, Lan T, Xie X, Peng J, Huang J, Wang S, Shen X, Liu P, Huang H.

PLoS One. 2012;7(8):e43874. doi: 10.1371/journal.pone.0043874. Epub 2012 Aug 24. Erratum in: PLoS One. 2012;7(10). doi:10.1371/annotation/e4e8ca0c-f6e8-4b32-aae1-b5f8e0c7ebc3.

12.

Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.

Wang X, Zhang DM, Gu TT, Ding XQ, Fan CY, Zhu Q, Shi YW, Hong Y, Kong LD.

Biochem Pharmacol. 2013 Dec 15;86(12):1791-804. doi: 10.1016/j.bcp.2013.10.005. Epub 2013 Oct 14.

PMID:
24134913
13.

Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription.

Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T.

J Cell Biochem. 2011 Nov;112(11):3449-58. doi: 10.1002/jcb.23275.

PMID:
21769916
14.

Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy.

Yaghobian D, Don AS, Yaghobian S, Chen X, Pollock CA, Saad S.

Clin Exp Pharmacol Physiol. 2016 Jan;43(1):56-66. doi: 10.1111/1440-1681.12494.

PMID:
26414003
15.

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells.

Huang K, Huang J, Xie X, Wang S, Chen C, Shen X, Liu P, Huang H.

Free Radic Biol Med. 2013 Dec;65:528-40. doi: 10.1016/j.freeradbiomed.2013.07.029. Epub 2013 Jul 24.

PMID:
23891678
16.

Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells.

Xie X, Peng J, Huang K, Huang J, Shen X, Liu P, Huang H.

Mol Cell Endocrinol. 2012 Oct 15;362(1-2):183-93. doi: 10.1016/j.mce.2012.06.008. Epub 2012 Jun 22.

PMID:
22732364
17.

Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: involvement of suppression of cell cycle progression and NF-κB/AP-1 pathways.

Lan T, Wu T, Chen C, Chen X, Hao J, Huang J, Wang L, Huang H.

Mol Cell Endocrinol. 2014 Mar 25;384(1-2):109-16. doi: 10.1016/j.mce.2014.01.022. Epub 2014 Feb 5.

PMID:
24508662
18.

Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells.

Liu X, Hong Q, Wang Z, Yu Y, Zou X, Xu L.

Exp Biol Med (Maywood). 2016 Feb;241(3):265-72. doi: 10.1177/1535370215605586. Epub 2015 Sep 16.

19.

PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells.

Wu D, Peng F, Zhang B, Ingram AJ, Kelly DJ, Gilbert RE, Gao B, Krepinsky JC.

J Am Soc Nephrol. 2009 Mar;20(3):554-66. doi: 10.1681/ASN.2008040445. Epub 2009 Feb 11.

20.

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