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Items: 1 to 20 of 163

1.

Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug.

Vega MC, Rolón M, Montero-Torres A, Fonseca-Berzal C, Escario JA, Gómez-Barrio A, Gálvez J, Marrero-Ponce Y, Arán VJ.

Eur J Med Chem. 2012 Dec;58:214-27. doi: 10.1016/j.ejmech.2012.10.009. Epub 2012 Oct 16.

PMID:
23124218
2.

Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles.

Fonseca-Berzal C, Ibáñez-Escribano A, Reviriego F, Cumella J, Morales P, Jagerovic N, Nogal-Ruiz JJ, Escario JA, da Silva PB, Soeiro Mde N, Gómez-Barrio A, Arán VJ.

Eur J Med Chem. 2016 Jun 10;115:295-310. doi: 10.1016/j.ejmech.2016.03.036. Epub 2016 Mar 17.

PMID:
27017556
3.

Further insights into biological evaluation of new anti-Trypanosoma cruzi 5-nitroindazoles.

Fonseca-Berzal C, Escario JA, Arán VJ, Gómez-Barrio A.

Parasitol Res. 2014 Mar;113(3):1049-56. doi: 10.1007/s00436-013-3740-5. Epub 2014 Jan 17.

PMID:
24435615
4.

Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series.

Dias LR, Santos MB, Albuquerque Sd, Castro HC, de Souza AM, Freitas AC, DiVaio MA, Cabral LM, Rodrigues CR.

Bioorg Med Chem. 2007 Jan 1;15(1):211-9. Epub 2006 Oct 1.

PMID:
17064907
5.

Synthesis and biological properties of new 5-nitroindazole derivatives.

Arán VJ, Ochoa C, Boiani L, Buccino P, Cerecetto H, Gerpe A, González M, Montero D, Nogal JJ, Gómez-Barrio A, Azqueta A, López de Ceráin A, Piro OE, Castellano EE.

Bioorg Med Chem. 2005 May 2;13(9):3197-207.

PMID:
15809155
6.

New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and mechanism of action studies.

Rodríguez J, Arán VJ, Boiani L, Olea-Azar C, Lavaggi ML, González M, Cerecetto H, Maya JD, Carrasco-Pozo C, Cosoy HS.

Bioorg Med Chem. 2009 Dec 15;17(24):8186-96. doi: 10.1016/j.bmc.2009.10.030. Epub 2009 Oct 20.

PMID:
19900812
7.

New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.

Carneiro PF, do Nascimento SB, Pinto AV, Pinto Mdo C, Lechuga GC, Santos DO, dos Santos Júnior HM, Resende JA, Bourguignon SC, Ferreira VF.

Bioorg Med Chem. 2012 Aug 15;20(16):4995-5000. doi: 10.1016/j.bmc.2012.06.027. Epub 2012 Jun 21.

PMID:
22795899
8.

Indazole N-oxide derivatives as antiprotozoal agents: synthesis, biological evaluation and mechanism of action studies.

Gerpe A, Aguirre G, Boiani L, Cerecetto H, González M, Olea-Azar C, Rigol C, Maya JD, Morello A, Piro OE, Arán VJ, Azqueta A, de Ceráin AL, Monge A, Rojas MA, Yaluff G.

Bioorg Med Chem. 2006 May 15;14(10):3467-80. Epub 2006 Feb 17.

PMID:
16483783
9.

Research for new antichagasic drugs.

Mester B, Claramunt RM, Elguero J, Atienza J, Gómez Barrio A, Escario JA.

Chem Pharm Bull (Tokyo). 1991 Aug;39(8):1990-3.

PMID:
1797419
10.

Synthesis and antichagasic properties of new 1,2,6-thiadiazin-3,5-dione 1,1-dioxides and related compounds.

Di Maio R, Cerecetto H, Seoane G, Ochoa C, Arán VJ, Pérez E, Gómez Barrio A, Muelas S.

Arzneimittelforschung. 1999 Sep;49(9):759-63.

PMID:
10514904
11.

Trypanocidal activity of 5,6-dihydropyran-2-ones against free trypomastigotes forms of Trypanosoma cruzi.

de Fátima A, Marquissolo C, de Albuquerque S, Carraro-Abrahão AA, Pilli RA.

Eur J Med Chem. 2006 Oct;41(10):1210-3. Epub 2006 Jul 3.

PMID:
16815596
12.

Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Structure-activity relationships. Part II.

Aguirre G, Cerecetto H, Di Maio R, González M, Porcal W, Seoane G, Ortega MA, Aldana I, Monge A, Denicola A.

Arch Pharm (Weinheim). 2002 Jan;335(1):15-21.

PMID:
11933675
13.

In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles.

Boiani L, Gerpe A, Arán VJ, Torres de Ortiz S, Serna E, Vera de Bilbao N, Sanabria L, Yaluff G, Nakayama H, Rojas de Arias A, Maya JD, Morello JA, Cerecetto H, González M.

Eur J Med Chem. 2009 Mar;44(3):1034-40. doi: 10.1016/j.ejmech.2008.06.024. Epub 2008 Jun 28.

PMID:
18706738
14.

Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi.

Elhalem E, Bailey BN, Docampo R, Ujváry I, Szajnman SH, Rodriguez JB.

J Med Chem. 2002 Aug 29;45(18):3984-99.

PMID:
12190320
15.

Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease.

Salas CO, Faúndez M, Morello A, Maya JD, Tapia RA.

Curr Med Chem. 2011;18(1):144-61. Review.

PMID:
21110810
16.

Anti-Trypanosoma activity of some natural stilbenoids and synthetic related heterocyclic compounds.

del Olmo E, Armas MG, López-Pérez JL, Ruiz G, Vargas F, Giménez A, Deharo E, San Feliciano A.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2755-7.

PMID:
11591517
17.

In vitro and in vivo trypanocidal evaluation of nickel complexes with an azapurine derivative against Trypanosoma cruzi.

Maldonado CR, Marín C, Olmo F, Huertas O, Quirós M, Sánchez-Moreno M, Rosales MJ, Salas JM.

J Med Chem. 2010 Oct 14;53(19):6964-72. doi: 10.1021/jm100581z.

PMID:
20812723
18.

Indazoles: a new top seed structure in the search of efficient drugs against Trypanosoma cruzi.

Aguilera-Venegas B, Olea-Azar C, Arán VJ, Speisky H.

Future Med Chem. 2013 Oct;5(15):1843-59. doi: 10.4155/fmc.13.144. Review.

PMID:
24144415
19.

Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.

Salas C, Tapia RA, Ciudad K, Armstrong V, Orellana M, Kemmerling U, Ferreira J, Maya JD, Morello A.

Bioorg Med Chem. 2008 Jan 15;16(2):668-74. Epub 2007 Oct 18.

PMID:
18029184
20.

Synthesis and biological characterization of new aryloxyindole-4,9-diones as potent trypanosomicidal agents.

Tapia RA, Salas CO, Vázquez K, Espinosa-Bustos C, Soto-Delgado J, Varela J, Birriel E, Cerecetto H, González M, Paulino M.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3919-22. doi: 10.1016/j.bmcl.2014.06.044. Epub 2014 Jun 24.

PMID:
25008454

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