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Items: 1 to 20 of 102

1.

BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation.

Métais JY, Winkler T, Geyer JT, Calado RT, Aplan PD, Eckhaus MA, Dunbar CE.

PLoS One. 2012;7(10):e48267. doi: 10.1371/journal.pone.0048267. Epub 2012 Oct 30.

2.

Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.

Campbell KJ, Bath ML, Turner ML, Vandenberg CJ, Bouillet P, Metcalf D, Scott CL, Cory S.

Blood. 2010 Oct 28;116(17):3197-207. doi: 10.1182/blood-2010-04-281071. Epub 2010 Jul 14.

3.

Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.

Wang Z, Medrzycki M, Bunting ST, Bunting KD.

Oncotarget. 2015 Oct 6;6(30):28961-72. doi: 10.18632/oncotarget.5009.

4.

Retroviral transduction of enriched hematopoietic stem cells allows lifelong Bcl-2 expression in multiple lineages but does not perturb hematopoiesis.

Innes KM, Szilvassy SJ, Davidson HE, Gibson L, Adams JM, Cory S.

Exp Hematol. 1999 Jan;27(1):75-87.

PMID:
9923446
5.

Homeobox genes in hematopoiesis and leukemogenesis.

Shimamoto T, Ohyashiki K, Toyama K, Takeshita K.

Int J Hematol. 1998 Jun;67(4):339-50. Review.

PMID:
9695407
6.

Leukemic predisposition of mice transplanted with gene-modified hematopoietic precursors expressing flt3 ligand.

Hawley TS, Fong AZ, Griesser H, Lyman SD, Hawley RG.

Blood. 1998 Sep 15;92(6):2003-11.

7.

Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.

Chang YI, You X, Kong G, Ranheim EA, Wang J, Du J, Liu Y, Zhou Y, Ryu MJ, Zhang J.

Leukemia. 2015 Sep;29(9):1847-56. doi: 10.1038/leu.2015.85. Epub 2015 Mar 24.

9.

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia.

Montes R, Ayllón V, Gutierrez-Aranda I, Prat I, Hernández-Lamas MC, Ponce L, Bresolin S, Te Kronnie G, Greaves M, Bueno C, Menendez P.

Blood. 2011 May 5;117(18):4746-58. doi: 10.1182/blood-2010-12-322230. Epub 2011 Mar 9.

10.

Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase.

Kitayama H, Tsujimura T, Matsumura I, Oritani K, Ikeda H, Ishikawa J, Okabe M, Suzuki M, Yamamura K, Matsuzawa Y, Kitamura Y, Kanakura Y.

Blood. 1996 Aug 1;88(3):995-1004.

11.

Hematopoietic transforming potential of activated ras in chimeric mice.

Hawley RG, Fong AZ, Ngan BY, Hawley TS.

Oncogene. 1995 Sep 21;11(6):1113-23.

PMID:
7566971
12.

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome.

Slape CI, Saw J, Jowett JB, Aplan PD, Strasser A, Jane SM, Curtis DJ.

Blood. 2012 Sep 20;120(12):2475-83. Epub 2012 Jul 31.

13.

Human T-cell leukemia virus type 1 tax oncoprotein suppression of multilineage hematopoiesis of CD34+ cells in vitro.

Tripp A, Liu Y, Sieburg M, Montalbano J, Wrzesinski S, Feuer G.

J Virol. 2003 Nov;77(22):12152-64.

14.

Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome.

Matsuura S, Komeno Y, Stevenson KE, Biggs JR, Lam K, Tang T, Lo MC, Cong X, Yan M, Neuberg DS, Zhang DE.

Blood. 2012 Nov 8;120(19):4028-37. doi: 10.1182/blood-2012-01-404533. Epub 2012 Aug 23.

15.

Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.

Tornack J, Seiler K, Grützkau A, Grün JR, Onodera M, Melchers F, Tsuneto M.

PLoS One. 2013 Jul 29;8(7):e70116. doi: 10.1371/journal.pone.0070116. Print 2013.

16.

Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells.

Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, Ishii S, Suzuki K, Shibata-Minoshima F, Katayama N, Kitamura T, Nosaka T.

Blood. 2013 Aug 15;122(7):1271-83. doi: 10.1182/blood-2012-09-456665. Epub 2013 Jul 9.

17.

Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation.

Jia Y, Peng L, Rao Q, Xing H, Huai L, Yu P, Chen Y, Wang C, Wang M, Mi Y, Wang J.

FASEB J. 2014 Jul;28(7):2816-27. doi: 10.1096/fj.13-244632. Epub 2014 Mar 25.

18.

Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival.

Kikushige Y, Yoshimoto G, Miyamoto T, Iino T, Mori Y, Iwasaki H, Niiro H, Takenaka K, Nagafuji K, Harada M, Ishikawa F, Akashi K.

J Immunol. 2008 Jun 1;180(11):7358-67.

19.

Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis.

Sánchez-Aguilera A, Arranz L, Martín-Pérez D, García-García A, Stavropoulou V, Kubovcakova L, Isern J, Martín-Salamanca S, Langa X, Skoda RC, Schwaller J, Méndez-Ferrer S.

Cell Stem Cell. 2014 Dec 4;15(6):791-804. doi: 10.1016/j.stem.2014.11.002.

20.

IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.

Jenkins CR, Shevchuk OO, Giambra V, Lam SH, Carboni JM, Gottardis MM, Holzenberger M, Pollak M, Humphries RK, Weng AP.

Exp Hematol. 2012 Sep;40(9):715-723.e6. doi: 10.1016/j.exphem.2012.05.003. Epub 2012 May 18.

PMID:
22613471

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