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PNUTS functions as a proto-oncogene by sequestering PTEN.

Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S.

Cancer Res. 2013 Jan 1;73(1):205-14. doi: 10.1158/0008-5472.CAN-12-1394. Epub 2012 Nov 1.


Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2.

Lee SJ, Lim CJ, Min JK, Lee JK, Kim YM, Lee JY, Won MH, Kwon YG.

Cell Death Differ. 2007 Jun;14(6):1106-16. Epub 2007 Feb 23.


A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.

Grelet S, Link LA, Howley B, Obellianne C, Palanisamy V, Gangaraju VK, Diehl JA, Howe PH.

Nat Cell Biol. 2017 Sep;19(9):1105-1115. doi: 10.1038/ncb3595. Epub 2017 Aug 21. Erratum in: Nat Cell Biol. 2017 Nov 29;19(12 ):1443.


Langerhans cell protein 1 (LCP1) binds to PNUTS in the nucleus: implications for this complex in transcriptional regulation.

Lee SJ, Lee JK, Maeng YS, Kim YM, Kwon YG.

Exp Mol Med. 2009 Mar 31;41(3):189-200. doi: 10.3858/emm.2009.41.3.022.


The miRNA miR-34a enhances HIV-1 replication by targeting PNUTS/PPP1R10, which negatively regulates HIV-1 transcriptional complex formation.

Kapoor R, Arora S, Ponia SS, Kumar B, Maddika S, Banerjea AC.

Biochem J. 2015 Sep 15;470(3):293-302. doi: 10.1042/BJ20150700. Epub 2015 Jul 17.


The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response.

Landsverk HB, Mora-Bermúdez F, Landsverk OJ, Hasvold G, Naderi S, Bakke O, Ellenberg J, Collas P, Syljuåsen RG, Küntziger T.

EMBO Rep. 2010 Nov;11(11):868-75. doi: 10.1038/embor.2010.134. Epub 2010 Oct 1.


Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.

Lehman JA, Waning DL, Batuello CN, Cipriano R, Kadakia MP, Mayo LD.

J Biol Chem. 2011 Oct 21;286(42):36631-40. doi: 10.1074/jbc.M110.217620. Epub 2011 Aug 26.


PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells.

De Leon G, Cavino M, D'Angelo M, Krucher NA.

Int J Oncol. 2010 May;36(5):1269-75.


MicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN.

Zhou K, Zhang T, Fan Y, Serick, Du G, Wu P, Geng D.

Tumour Biol. 2016 Oct;37(10):13469-13477. Epub 2016 Jul 27.


PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner.

Landsverk HB, Kirkhus M, Bollen M, Küntziger T, Collas P.

Biochem J. 2005 Sep 15;390(Pt 3):709-17.


Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.

Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4097-102. doi: 10.1073/pnas.1317395111. Epub 2014 Mar 3.


PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway.

Tian T, Nan KJ, Guo H, Wang WJ, Ruan ZP, Wang SH, Liang X, Lu CX.

Oncol Rep. 2010 Jun;23(6):1593-600.


Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells.

Cheng Z, Yang N, Liang W, Yan X, Li L, Pan L.

Leuk Lymphoma. 2012 Jul;53(7):1383-9. doi: 10.3109/10428194.2011.650695. Epub 2012 Jan 31.


PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.

Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG.

J Biol Chem. 2003 Apr 18;278(16):13819-28. Epub 2003 Feb 6.


CREB is a novel nuclear target of PTEN phosphatase.

Gu T, Zhang Z, Wang J, Guo J, Shen WH, Yin Y.

Cancer Res. 2011 Apr 15;71(8):2821-5. doi: 10.1158/0008-5472.CAN-10-3399. Epub 2011 Mar 8.


RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation.

Lee JT, Shan J, Zhong J, Li M, Zhou B, Zhou A, Parsons R, Gu W.

Cell Res. 2013 Apr;23(4):552-64. doi: 10.1038/cr.2013.27. Epub 2013 Feb 19.


Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis.

De Leon G, Sherry TC, Krucher NA.

Cancer Biol Ther. 2008 Jun;7(6):833-41. Epub 2008 Mar 5.


Identification and characterization of a novel human PP1 phosphatase complex.

Lee JH, You J, Dobrota E, Skalnik DG.

J Biol Chem. 2010 Aug 6;285(32):24466-76. doi: 10.1074/jbc.M110.109801. Epub 2010 Jun 1.


NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma.

Liu S, Ma X, Ai Q, Huang Q, Shi T, Zhu M, Wang B, Zhang X.

Urol Oncol. 2013 Aug;31(6):938-48. doi: 10.1016/j.urolonc.2011.07.006. Epub 2011 Oct 10.


Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.

Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9472-7. doi: 10.1073/pnas.1101296108. Epub 2011 May 18. Erratum in: Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2411.

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