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Items: 1 to 20 of 211

1.

Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA.

Annadurai S, Martinez R, Canney DJ, Eidem T, Dunman PM, Abou-Gharbia M.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7719-25. doi: 10.1016/j.bmcl.2012.09.095. Epub 2012 Oct 3.

PMID:
23116888
2.

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

Huigens RW 3rd, Reyes S, Reed CS, Bunders C, Rogers SA, Steinhauer AT, Melander C.

Bioorg Med Chem. 2010 Jan 15;18(2):663-74. doi: 10.1016/j.bmc.2009.12.003. Epub 2009 Dec 6.

PMID:
20044260
3.

Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).

Kim HY, Wiles JA, Wang Q, Pais GC, Lucien E, Hashimoto A, Nelson DM, Thanassi JA, Podos SD, Deshpande M, Pucci MJ, Bradbury BJ.

J Med Chem. 2011 May 12;54(9):3268-82. doi: 10.1021/jm101604v. Epub 2011 Apr 15.

PMID:
21425851
4.

Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria.

Kane JL Jr, Hirth BH, Liang B, Gourlie BB, Nahill S, Barsomian G.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4463-6.

PMID:
14643347
5.

Synthesis and antibacterial evaluation of a novel series of synthetic phenylthiazole compounds against methicillin-resistant Staphylococcus aureus (MRSA).

Mohammad H, Reddy PV, Monteleone D, Mayhoub AS, Cushman M, Seleem MN.

Eur J Med Chem. 2015 Apr 13;94:306-16. doi: 10.1016/j.ejmech.2015.03.015. Epub 2015 Mar 7.

6.

The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains.

Hardej D, Ashby CR Jr, Khadtare NS, Kulkarni SS, Singh S, Talele TT.

Eur J Med Chem. 2010 Dec;45(12):5827-32. doi: 10.1016/j.ejmech.2010.09.045. Epub 2010 Sep 25.

PMID:
20947220
7.

Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii.

Su Z, Peng L, Worthington RJ, Melander C.

ChemMedChem. 2011 Dec 9;6(12):2243-51. doi: 10.1002/cmdc.201100316. Epub 2011 Sep 16.

PMID:
21928438
8.

Synthesis and biological screening of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyls as possible anti-tubercular and antimicrobial agents.

Abhale YK, Sasane AV, Chavan AP, Deshmukh KK, Kotapalli SS, Ummanni R, Sayyad SF, Mhaske PC.

Eur J Med Chem. 2015 Apr 13;94:340-7. doi: 10.1016/j.ejmech.2015.03.016. Epub 2015 Mar 7.

PMID:
25778990
9.

Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents.

Shang JL, Guo H, Li ZS, Ren B, Li ZM, Dai HQ, Zhang LX, Wang JG.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):724-7. doi: 10.1016/j.bmcl.2012.11.103. Epub 2012 Dec 3.

PMID:
23265879
10.

Riccardin C derivatives as anti-MRSA agents: structure-activity relationship of a series of hydroxylated bis(bibenzyl)s.

Sawada H, Okazaki M, Morita D, Kuroda T, Matsuno K, Hashimoto Y, Miyachi H.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7444-7. doi: 10.1016/j.bmcl.2012.10.052. Epub 2012 Oct 17.

PMID:
23122868
11.

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents.

Zhou C, Min J, Liu Z, Young A, Deshazer H, Gao T, Chang YT, Kallenbach NR.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1308-11. doi: 10.1016/j.bmcl.2008.01.031. Epub 2008 Jan 11.

PMID:
18226902
12.

Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory antimicrobial agents.

Bekhit AA, Fahmy HT, Rostom SA, El-Din A Bekhit A.

Eur J Med Chem. 2010 Dec;45(12):6027-38. doi: 10.1016/j.ejmech.2010.10.001. Epub 2010 Oct 20.

PMID:
20970223
13.

A multivalent approach to drug discovery for novel antibiotics.

Long DD, Aggen JB, Christensen BG, Judice JK, Hegde SS, Kaniga K, Krause KM, Linsell MS, Moran EJ, Pace JL.

J Antibiot (Tokyo). 2008 Oct;61(10):595-602. doi: 10.1038/ja.2008.79.

PMID:
19168973
14.

N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus.

Turos E, Long TE, Konaklieva MI, Coates C, Shim JY, Dickey S, Lim DV, Cannons A.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2229-31.

PMID:
12127544
15.

High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase.

Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW, Cheng YS, Cheng WC, Wong CH.

Bioorg Med Chem. 2010 Dec 15;18(24):8512-29. doi: 10.1016/j.bmc.2010.10.036. Epub 2010 Oct 21.

PMID:
21075637
16.

Synthesis and potent antimicrobial activity of some novel 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides.

Ozden S, Karataş H, Yildiz S, Göker H.

Arch Pharm (Weinheim). 2004 Oct;337(10):556-62.

PMID:
15476288
17.

Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis.

Eid I, Elsebaei MM, Mohammad H, Hagras M, Peters CE, Hegazy YA, Cooper B, Pogliano J, Pogliano K, Abulkhair HS, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2017 Oct 20;139:665-673. doi: 10.1016/j.ejmech.2017.08.039. Epub 2017 Aug 18.

PMID:
28846967
18.

Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors.

Cheng K, Xue JY, Zhu HL.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4235-8. doi: 10.1016/j.bmcl.2013.05.006. Epub 2013 May 10.

PMID:
23731945
19.

Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents.

Ran K, Gao C, Deng H, Lei Q, You X, Wang N, Shi Y, Liu Z, Wei W, Peng C, Xiong L, Xiao K, Yu L.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3669-74. doi: 10.1016/j.bmcl.2016.05.088. Epub 2016 May 30.

PMID:
27289321
20.

The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds.

Patel BA, Ashby CR Jr, Hardej D, Talele TT.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5523-7. doi: 10.1016/j.bmcl.2013.08.059. Epub 2013 Aug 20.

PMID:
24012180

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