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Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.

White JP, Gao S, Puppa MJ, Sato S, Welle SL, Carson JA.

Mol Cell Endocrinol. 2013 Jan 30;365(2):174-86. doi: 10.1016/j.mce.2012.10.019. Epub 2012 Oct 29.


AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1.

Sanchez AM, Csibi A, Raibon A, Cornille K, Gay S, Bernardi H, Candau R.

J Cell Biochem. 2012 Feb;113(2):695-710. doi: 10.1002/jcb.23399.


Testosterone signals through mTOR and androgen receptor to induce muscle hypertrophy.

Basualto-Alarcón C, Jorquera G, Altamirano F, Jaimovich E, Estrada M.

Med Sci Sports Exerc. 2013 Sep;45(9):1712-20. doi: 10.1249/MSS.0b013e31828cf5f3.


Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK.

White JP, Puppa MJ, Gao S, Sato S, Welle SL, Carson JA.

Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1042-52. doi: 10.1152/ajpendo.00410.2012. Epub 2013 Mar 26.


Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats.

Luo L, Lu AM, Wang Y, Hong A, Chen Y, Hu J, Li X, Qin ZH.

Exp Gerontol. 2013 Apr;48(4):427-36. doi: 10.1016/j.exger.2013.02.009. Epub 2013 Feb 16.


AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.

Tandelilin AA, Hirase T, Hudoyo AW, Cheng J, Toyama K, Morisaki H, Morisaki T.

BMC Endocr Disord. 2015 Mar 27;15:11. doi: 10.1186/s12902-015-0010-9. Erratum in: BMC Endocr Disord. 2015;15:80.


Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.

Pöllänen E, Ronkainen PH, Horttanainen M, Takala T, Puolakka J, Suominen H, Sipilä S, Kovanen V.

Growth Horm IGF Res. 2010 Oct;20(5):372-9. doi: 10.1016/j.ghir.2010.07.003. Epub 2010 Aug 17.


Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.

Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1258-70. doi: 10.1152/ajpcell.00105.2009. Epub 2009 Apr 8.


Resveratrol prevents TNF-α-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes.

Wang DT, Yin Y, Yang YJ, Lv PJ, Shi Y, Lu L, Wei LB.

Int Immunopharmacol. 2014 Apr;19(2):206-13. doi: 10.1016/j.intimp.2014.02.002. Epub 2014 Feb 15.


Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.

Sandri M, Barberi L, Bijlsma AY, Blaauw B, Dyar KA, Milan G, Mammucari C, Meskers CG, Pallafacchina G, Paoli A, Pion D, Roceri M, Romanello V, Serrano AL, Toniolo L, Larsson L, Maier AB, Muñoz-Cánoves P, Musarò A, Pende M, Reggiani C, Rizzuto R, Schiaffino S.

Biogerontology. 2013 Jun;14(3):303-23. doi: 10.1007/s10522-013-9432-9. Epub 2013 May 19.


PI3 kinase regulation of skeletal muscle hypertrophy and atrophy.

Glass DJ.

Curr Top Microbiol Immunol. 2010;346:267-78. doi: 10.1007/82_2010_78. Review.


Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy.

Hulmi JJ, Silvennoinen M, Lehti M, Kivelä R, Kainulainen H.

Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E307-15. doi: 10.1152/ajpendo.00398.2011. Epub 2011 Nov 8.


Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle.

Joassard OR, Amirouche A, Gallot YS, Desgeorges MM, Castells J, Durieux AC, Berthon P, Freyssenet DG.

Int J Biochem Cell Biol. 2013 Nov;45(11):2444-55. doi: 10.1016/j.biocel.2013.07.019. Epub 2013 Aug 2.


Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes.

Frost RA, Huber D, Pruznak A, Lang CH.

J Cell Biochem. 2009 Dec 1;108(5):1192-202. doi: 10.1002/jcb.22349.


Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells.

Clavel S, Siffroi-Fernandez S, Coldefy AS, Boulukos K, Pisani DF, Dérijard B.

Mol Cell Biol. 2010 Jan;30(2):470-80. doi: 10.1128/MCB.00666-09. Epub 2009 Nov 16.


Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.


The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity.

Bonifacio A, Sanvee GM, Bouitbir J, Krähenbühl S.

Biochim Biophys Acta. 2015 Aug;1853(8):1841-9. doi: 10.1016/j.bbamcr.2015.04.010. Epub 2015 Apr 23.

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