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Items: 1 to 20 of 105

1.

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells.

Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A.

Islets. 2012 Sep-Oct;4(5):354-8. doi: 10.4161/isl.22538. Epub 2012 Sep 1.

2.

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets.

Jayaram B, Syed I, Kyathanahalli CN, Rhodes CJ, Kowluru A.

Biochem Pharmacol. 2011 Apr 15;81(8):1016-27. doi: 10.1016/j.bcp.2011.01.006. Epub 2011 Jan 26.

3.

Glucose activates prenyltransferases in pancreatic islet beta-cells.

Goalstone M, Kamath V, Kowluru A.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):895-8. doi: 10.1016/j.bbrc.2009.11.159. Epub 2009 Nov 29.

4.

Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells.

Veluthakal R, Arora DK, Goalstone ML, Kowluru RA, Kowluru A.

Cell Physiol Biochem. 2016;39(6):2110-2120. Epub 2016 Nov 2.

5.

VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.

Veluthakal R, Tunduguru R, Arora DK, Sidarala V, Syeda K, Vlaar CP, Thurmond DC, Kowluru A.

Diabetologia. 2015 Nov;58(11):2573-81. doi: 10.1007/s00125-015-3707-4. Epub 2015 Jul 31.

6.

Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.

Kowluru A, Veluthakal R, Rhodes CJ, Kamath V, Syed I, Koch BJ.

Diabetes. 2010 Apr;59(4):967-77. doi: 10.2337/db09-1334. Epub 2010 Jan 13.

7.

Nm23-H1 regulates glucose-stimulated insulin secretion in pancreatic β-cells via Arf6-Rac1 signaling axis.

Veluthakal R, Kaetzel D, Kowluru A.

Cell Physiol Biochem. 2013;32(3):533-41. doi: 10.1159/000354457. Epub 2013 Aug 30.

8.

EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.

Sidarala V, Veluthakal R, Syeda K, Kowluru A.

Cell Signal. 2015 Jun;27(6):1159-67. doi: 10.1016/j.cellsig.2015.02.020. Epub 2015 Feb 26.

9.
11.

Protein prenylation in islet β-cell function in health and diabetes: Putting the pieces of the puzzle together.

Kowluru A, Kowluru RA.

Biochem Pharmacol. 2015 Dec 1;98(3):363-70. doi: 10.1016/j.bcp.2015.07.004. Epub 2015 Jul 26.

PMID:
26215874
12.

Sequence dependence of protein isoprenylation.

Moores SL, Schaber MD, Mosser SD, Rands E, O'Hara MB, Garsky VM, Marshall MS, Pompliano DL, Gibbs JB.

J Biol Chem. 1991 Aug 5;266(22):14603-10.

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16.

Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells.

Jayaram B, Syed I, Singh A, Subasinghe W, Kyathanahalli CN, Kowluru A.

Islets. 2011 Mar-Apr;3(2):48-57. Epub 2011 Mar 1.

17.

Insulin signals to prenyltransferases via the Shc branch of intracellular signaling.

Goalstone ML, Leitner JW, Berhanu P, Sharma PM, Olefsky JM, Draznin B.

J Biol Chem. 2001 Apr 20;276(16):12805-12. Epub 2001 Jan 25.

18.

A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGE₂.

Kyathanahalli CN, Kowluru A.

Biochem Pharmacol. 2011 May 15;81(10):1237-47. doi: 10.1016/j.bcp.2011.03.002. Epub 2011 Mar 23.

19.

Inhibition of glucose- and calcium-induced insulin secretion from betaTC3 cells by novel inhibitors of protein isoprenylation.

Amin R, Chen HQ, Tannous M, Gibbs R, Kowluru A.

J Pharmacol Exp Ther. 2002 Oct;303(1):82-8.

20.

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