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Items: 1 to 20 of 122

1.

Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants.

Uno T, Obe Y, Ogura C, Goto T, Yamamoto K, Nakamura M, Kanamaru K, Yamagata H, Imaishi H.

Biopharm Drug Dispos. 2013 Mar;34(2):87-97. doi: 10.1002/bdd.1825. Epub 2012 Dec 4.

PMID:
23112005
2.

Point mutation of cytochrome P450 2A6 (a polymorphic variant CYP2A6.25) confers new substrate specificity towards flavonoids.

Uno T, Ogura C, Izumi C, Nakamura M, Yanase T, Yamazaki H, Ashida H, Kanamaru K, Yamagata H, Imaishi H.

Biopharm Drug Dispos. 2015 Nov;36(8):552-63. doi: 10.1002/bdd.1966. Epub 2015 Aug 31.

PMID:
26222491
3.

Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis.

Kim D, Wu ZL, Guengerich FP.

J Biol Chem. 2005 Dec 2;280(48):40319-27. Epub 2005 Oct 5.

4.
5.

Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35).

Han S, Choi S, Chun YJ, Yun CH, Lee CH, Shin HJ, Na HS, Chung MW, Kim D.

Biol Pharm Bull. 2012;35(3):394-9.

6.

The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.

Duarte MP, Palma BB, Gilep AA, Laires A, Oliveira JS, Usanov SA, Rueff J, Kranendonk M.

Mutagenesis. 2005 Mar;20(2):93-100. Epub 2005 Feb 22. Erratum in: Mutagenesis. 2007 Jan;22(1):75-81.

PMID:
15728263
7.

Cyp2a6 is a principal enzyme involved in hydroxylation of 1,7-dimethylxanthine, a main caffeine metabolite, in humans.

Kimura M, Yamazaki H, Fujieda M, Kiyotani K, Honda G, Saruwatari J, Nakagawa K, Ishizaki T, Kamataki T.

Drug Metab Dispos. 2005 Sep;33(9):1361-6. Epub 2005 Jun 24.

8.
9.

Functional characterization of cytochrome P450 2A6 allelic variants CYP2A6*15, CYP2A6*16, CYP2A6*21, and CYP2A6*22.

Tiong KH, Yiap BC, Tan EL, Ismail R, Ong CE.

Drug Metab Dispos. 2010 May;38(5):745-51. doi: 10.1124/dmd.109.031054. Epub 2010 Feb 5.

11.

Novel sensitive high-performance liquid chromatographic method for assay of coumarin 7-hydroxylation.

Soucek P.

J Chromatogr B Biomed Sci Appl. 1999 Oct 29;734(1):23-9.

PMID:
10574186
13.

Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole.

Ueng YF, Hsieh CH, Don MJ.

Food Chem Toxicol. 2005 May;43(5):707-12.

PMID:
15778010
14.
15.

Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen.

Koenigs LL, Peter RM, Thompson SJ, Rettie AE, Trager WF.

Drug Metab Dispos. 1997 Dec;25(12):1407-15.

16.

A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502).

Nunoya K, Yokoi T, Kimura K, Inoue K, Kodama T, Funayama M, Nagashima K, Funae Y, Green C, Kinoshita M, Kamataki T.

Pharmacogenetics. 1998 Jun;8(3):239-49.

PMID:
9682269
18.

A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.

Fukami T, Nakajima M, Higashi E, Yamanaka H, McLeod HL, Yokoi T.

Biochem Pharmacol. 2005 Sep 1;70(5):801-8.

PMID:
15993850
19.

A novel polymorphism of human CYP2A6 gene CYP2A6*17 has an amino acid substitution (V365M) that decreases enzymatic activity in vitro and in vivo.

Fukami T, Nakajima M, Yoshida R, Tsuchiya Y, Fujiki Y, Katoh M, McLeod HL, Yokoi T.

Clin Pharmacol Ther. 2004 Dec;76(6):519-27.

PMID:
15592323
20.

Engineering bacterial cytochrome P450 (P450) BM3 into a prototype with human P450 enzyme activity using indigo formation.

Park SH, Kim DH, Kim D, Kim DH, Jung HC, Pan JG, Ahn T, Kim D, Yun CH.

Drug Metab Dispos. 2010 May;38(5):732-9. doi: 10.1124/dmd.109.030759. Epub 2010 Jan 25.

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