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Fatty acid synthase inhibitor cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis.

Jeong NY, Lee JS, Yoo KS, Oh S, Choe E, Lee HJ, Park BS, Choi YH, Yoo YH.

Apoptosis. 2013 Feb;18(2):226-37. doi: 10.1007/s10495-012-0776-4.


Cerulenin-induced apoptosis is mediated by disrupting the interaction between AIF and hexokinase II.

Jeong NY, Yoo YH.

Int J Oncol. 2012 Jun;40(6):1949-56. doi: 10.3892/ijo.2012.1401. Epub 2012 Mar 15.


Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.

Rossato FA, Zecchin KG, La Guardia PG, Ortega RM, Alberici LC, Costa RA, Catharino RR, Graner E, Castilho RF, Vercesi AE.

PLoS One. 2014 Jun 25;9(6):e101060. doi: 10.1371/journal.pone.0101060. eCollection 2014.


Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model.

Bastos DC, Paupert J, Maillard C, Seguin F, Carvalho MA, Agostini M, Coletta RD, Noël A, Graner E.

Lab Invest. 2017 Feb;97(2):194-206. doi: 10.1038/labinvest.2016.125. Epub 2016 Dec 5.


Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells.

Vazquez-Martin A, Ropero S, Brunet J, Colomer R, Menendez JA.

Oncol Rep. 2007 Oct;18(4):973-80.


Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis.

Lee KH, Lee MS, Cha EY, Sul JY, Lee JS, Kim JS, Park JB, Kim JY.

Mol Med Rep. 2017 Apr;15(4):2163-2173. doi: 10.3892/mmr.2017.6254. Epub 2017 Feb 28.


Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer.

Bauerschlag DO, Maass N, Leonhardt P, Verburg FA, Pecks U, Zeppernick F, Morgenroth A, Mottaghy FM, Tolba R, Meinhold-Heerlein I, Bräutigam K.

J Transl Med. 2015 May 7;13:146. doi: 10.1186/s12967-015-0511-3.


Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells.

Shiragami R, Murata S, Kosugi C, Tezuka T, Yamazaki M, Hirano A, Yoshimura Y, Suzuki M, Shuto K, Koda K.

Int J Oncol. 2013 Aug;43(2):431-8. doi: 10.3892/ijo.2013.1978. Epub 2013 Jun 7.


Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer.

Tomek K, Wagner R, Varga F, Singer CF, Karlic H, Grunt TW.

Mol Cancer Res. 2011 Dec;9(12):1767-79. doi: 10.1158/1541-7786.MCR-10-0467. Epub 2011 Oct 4.


Fatty acid synthase is a novel therapeutic target in multiple myeloma.

Okawa Y, Hideshima T, Ikeda H, Raje N, Vallet S, Kiziltepe T, Yasui H, Enatsu S, Pozzi S, Breitkreutz I, Cirstea D, Santo L, Richardson P, Anderson KC.

Br J Haematol. 2008 May;141(5):659-71. doi: 10.1111/j.1365-2141.2008.07114.x. Epub 2008 Apr 10. Retraction in: Cotter F. Br J Haematol. 2008 May;141(5):659.


[An experimental study on cerulenin induced apoptosis of human colonic cancer cells].

Huang P, Zhu S, Lu S, Dai Z, Jin Y.

Zhonghua Bing Li Xue Za Zhi. 2000 Apr;29(2):115-8. Chinese.


The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells.

Hughes DT, Martel PM, Kinlaw WB, Eisenberg BL.

Cancer Invest. 2008 Mar;26(2):118-27. doi: 10.1080/07357900701522612.


Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells.

Ho TS, Ho YP, Wong WY, Chi-Ming Chiu L, Wong YS, Eng-Choon Ooi V.

Biomed Pharmacother. 2007 Oct;61(9):578-87. Epub 2007 Sep 14.


Key role of mitochondria in cerulenin-mediated apoptosis.

Heiligtag SJ, Bredehorst R, David KA.

Cell Death Differ. 2002 Sep;9(9):1017-25.


Synergistic effects of topoisomerase I inhibitor, 7-ethyl-10-hydroxycamptothecin, and irradiation in a cisplatin-resistant human small cell lung cancer cell line.

Kohara H, Tabata M, Kiura K, Ueoka H, Kawata K, Chikamori M, Aoe K, Chikamori K, Matsushita A, Harada M.

Clin Cancer Res. 2002 Jan;8(1):287-92.


Phosphatidylinositol 3-kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines.

Badinloo M, Esmaeili-Mahani S.

Fundam Clin Pharmacol. 2014 Aug;28(4):414-22. doi: 10.1111/fcp.12043. Epub 2013 Jul 10.


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