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Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.

Bacci S, Prudente S, Copetti M, Spoto B, Rizza S, Baratta R, Di Pietro N, Morini E, Di Paola R, Testa A, Mallamaci F, Tripepi G, Zhang YY, Mercuri L, Di Silvestre S, Lauro R, Malatino L, Consoli A, Pellegrini F, Pandolfi A, Frittitta L, Zoccali C, Federici M, Doria A, Trischitta V.

Atherosclerosis. 2013 Jan;226(1):140-5. doi: 10.1016/j.atherosclerosis.2012.10.035. Epub 2012 Oct 16.


Joint effect of insulin signaling genes on all-cause mortality.

Menzaghi C, Fontana A, Copetti M, Rizza S, Spoto B, Buranasupkajorn P, Tripepi G, Marucci A, Bailetti D, Hastings T, Testa A, Mendonca C, Mallamaci F, De Cosmo S, Bacci S, Federici M, Doria A, Zoccali C, Trischitta V.

Atherosclerosis. 2014 Dec;237(2):639-44. doi: 10.1016/j.atherosclerosis.2014.10.005. Epub 2014 Oct 24.


The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.

Bacci S, Rizza S, Prudente S, Spoto B, Powers C, Facciorusso A, Pacilli A, Lauro D, Testa A, Zhang YY, Di Stolfo G, Mallamaci F, Tripepi G, Xu R, Mangiacotti D, Aucella F, Lauro R, Gervino EV, Hauser TH, Copetti M, De Cosmo S, Pellegrini F, Zoccali C, Federici M, Doria A, Trischitta V.

Diabetes. 2011 Mar;60(3):1000-7. doi: 10.2337/db10-1300. Epub 2011 Jan 31.


TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.

Andreozzi F, Formoso G, Prudente S, Hribal ML, Pandolfi A, Bellacchio E, Di Silvestre S, Trischitta V, Consoli A, Sesti G.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1355-60. doi: 10.1161/ATVBAHA.108.162883. Epub 2008 Apr 24.


Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5.

Trombetta M, Dauriz M, Bonetti S, Travia D, Boselli L, Santi L, Bonora E, Bonadonna RC.

Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):232-8. doi: 10.1016/j.numecd.2016.01.002. Epub 2016 Jan 14.


Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.

Prudente S, Morini E, Marselli L, Baratta R, Copetti M, Mendonca C, Andreozzi F, Chandalia M, Pellegrini F, Bailetti D, Alberico F, Shah H, Abate N, Sesti G, Frittitta L, Marchetti P, Doria A, Trischitta V.

J Clin Endocrinol Metab. 2013 Jun;98(6):E1143-7. doi: 10.1210/jc.2012-4282. Epub 2013 Apr 30.


ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells.

Bacci S, Di Paola R, Menzaghi C, Di Fulvio P, Di Silvestre S, Pellegrini F, Baratta R, Marucci A, Mastroianno S, Fini G, Formoso G, Consoli A, Perticone F, Frittitta L, Pandolfi A, Trischitta V.

Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1678-83. doi: 10.1161/ATVBAHA.109.189191. Epub 2009 Aug 13.


Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.

Prudente S, Morini E, Trischitta V.

Nat Rev Endocrinol. 2009 Dec;5(12):682-93. doi: 10.1038/nrendo.2009.215. Review.


Body fat distribution and their associations with cardiovascular risk, insulin resistance and β-cell function: are there differences between men and women?

Chen G, Liu C, Chen F, Yao J, Jiang Q, Chen N, Huang H, Liang J, Li L, Lin L.

Int J Clin Pract. 2011 May;65(5):592-601. doi: 10.1111/j.1742-1241.2011.02653.x.


G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.

Federici M, Pandolfi A, De Filippis EA, Pellegrini G, Menghini R, Lauro D, Cardellini M, Romano M, Sesti G, Lauro R, Consoli A.

Circulation. 2004 Jan 27;109(3):399-405. Epub 2004 Jan 5.


Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study.

Rutter MK, Meigs JB, Sullivan LM, D'Agostino RB Sr, Wilson PW.

Diabetes. 2005 Nov;54(11):3252-7.


New measure of insulin sensitivity predicts cardiovascular disease better than HOMA estimated insulin resistance.

Venkataraman K, Khoo CM, Leow MK, Khoo EY, Isaac AV, Zagorodnov V, Sadananthan SA, Velan SS, Chong YS, Gluckman P, Lee J, Salim A, Tai ES, Lee YS.

PLoS One. 2013 Sep 30;8(9):e74410. doi: 10.1371/journal.pone.0074410. eCollection 2013.


Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in caucasian subjects from the general population: the Bruneck study.

Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Meigs JB, Bonadonna RC, Muggeo M.

Diabetes Care. 2007 Feb;30(2):318-24.


Obstructive sleep apnea is independently associated with inflammation and insulin resistance, but not with blood pressure, plasma catecholamines, and endothelial function in obese subjects.

Araújo Lda S, Fernandes JF, Klein MR, Sanjuliani AF.

Nutrition. 2015 Nov-Dec;31(11-12):1351-7. doi: 10.1016/j.nut.2015.05.017. Epub 2015 Jun 20.


Rationale and design of the LURIC study--a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease.

Winkelmann BR, März W, Boehm BO, Zotz R, Hager J, Hellstern P, Senges J; LURIC Study Group (LUdwigshafen RIsk and Cardiovascular Health).

Pharmacogenomics. 2001 Feb;2(1 Suppl 1):S1-73. Review.


Fasting and OGTT-derived measures of insulin resistance as compared with the euglycemic-hyperinsulinemic clamp in nondiabetic Finnish offspring of type 2 diabetic individuals.

Lorenzo C, Haffner SM, Stančáková A, Kuusisto J, Laakso M.

J Clin Endocrinol Metab. 2015 Feb;100(2):544-50. doi: 10.1210/jc.2014-2299. Epub 2014 Nov 11.


Insulin Resistance and Risk of Cardiovascular Disease in Postmenopausal Women: A Cohort Study From the Women's Health Initiative.

Schmiegelow MD, Hedlin H, Stefanick ML, Mackey RH, Allison M, Martin LW, Robinson JG, Hlatky MA.

Circ Cardiovasc Qual Outcomes. 2015 May;8(3):309-16. doi: 10.1161/CIRCOUTCOMES.114.001563. Epub 2015 May 5.


The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.

Formoso G, Di Tomo P, Andreozzi F, Succurro E, Di Silvestre S, Prudente S, Perticone F, Trischitta V, Sesti G, Pandolfi A, Consoli A.

Cardiovasc Res. 2011 Jan 1;89(1):184-92. doi: 10.1093/cvr/cvq255. Epub 2010 Aug 5.


Endothelial dysfunction plays a key role in increasing cardiovascular risk in type 2 diabetes: the Hoorn study.

van Sloten TT, Henry RM, Dekker JM, Nijpels G, Unger T, Schram MT, Stehouwer CD.

Hypertension. 2014 Dec;64(6):1299-305. doi: 10.1161/HYPERTENSIONAHA.114.04221. Epub 2014 Sep 15.


The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.

Prudente S, Trischitta V.

Biochem Soc Trans. 2015 Oct;43(5):1108-11. doi: 10.1042/BST20150115. Review.


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