Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 86

1.

Tacrine-6-ferulic acid, a novel multifunctional dimer against Alzheimer's disease, prevents oxidative stress-induced neuronal death through activating Nrf2/ARE/HO-1 pathway in HT22 cells.

Huang WY, Chao XJ, Ouyang Y, Liu AM, He XX, Chen MH, Wang LH, Liu J, Yu SW, Rapposelli S, Pi RB.

CNS Neurosci Ther. 2012 Nov;18(11):950-1. doi: 10.1111/cns.12010. No abstract available.

PMID:
23106978
2.

Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-induced cell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway.

Chao XJ, Chen ZW, Liu AM, He XX, Wang SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Cui W, Kong AN, Yu ZL, Han YF, Pi RB.

CNS Neurosci Ther. 2014 Sep;20(9):840-50. doi: 10.1111/cns.12286. Epub 2014 Jun 12.

PMID:
24922524
3.

Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo.

Pi R, Mao X, Chao X, Cheng Z, Liu M, Duan X, Ye M, Chen X, Mei Z, Liu P, Li W, Han Y.

PLoS One. 2012;7(2):e31921. doi: 10.1371/journal.pone.0031921. Epub 2012 Feb 23.

4.
5.
6.

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.

Benchekroun M, Romero A, Egea J, León R, Michalska P, Buendía I, Jimeno ML, Jun D, Janockova J, Sepsova V, Soukup O, Bautista-Aguilera OM, Refouvelet B, Ouari O, Marco-Contelles J, Ismaili L.

J Med Chem. 2016 Nov 10;59(21):9967-9973. Epub 2016 Oct 31.

PMID:
27736061
7.

Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB.

Khodagholi F, Eftekharzadeh B, Maghsoudi N, Rezaei PF.

Mol Cell Biochem. 2010 Apr;337(1-2):39-51. doi: 10.1007/s11010-009-0284-1. Epub 2009 Oct 21.

PMID:
19844776
8.

Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway.

Zhang H, Mak S, Cui W, Li W, Han R, Hu S, Ye M, Pi R, Han Y.

Neurochem Int. 2011 Dec;59(7):981-8. doi: 10.1016/j.neuint.2011.09.001. Epub 2011 Sep 10.

PMID:
21939707
9.

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.

Digiacomo M, Chen Z, Wang S, Lapucci A, Macchia M, Yang X, Chu J, Han Y, Pi R, Rapposelli S.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):807-10. doi: 10.1016/j.bmcl.2014.12.084. Epub 2015 Jan 6.

PMID:
25597007
10.

The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.

Espada S, Ortega F, Molina-Jijón E, Rojo AI, Pérez-Sen R, Pedraza-Chaverri J, Miras-Portugal MT, Cuadrado A.

Free Radic Biol Med. 2010 Aug 1;49(3):416-26. doi: 10.1016/j.freeradbiomed.2010.04.031. Epub 2010 May 4.

PMID:
20447456
11.

Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway.

Qaisiya M, Coda Zabetta CD, Bellarosa C, Tiribelli C.

Cell Signal. 2014 Mar;26(3):512-20. doi: 10.1016/j.cellsig.2013.11.029. Epub 2013 Dec 2.

PMID:
24308969
12.

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline.

Koriyama Y, Nakayama Y, Matsugo S, Kato S.

Brain Res. 2013 Mar 7;1499:145-57. doi: 10.1016/j.brainres.2012.12.041. Epub 2013 Jan 4.

PMID:
23295186
13.

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.

Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, López MG, Wehle S, Gharbi T, Refouvelet B, de Andrés L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodríguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L.

ChemMedChem. 2015 Mar;10(3):523-39. doi: 10.1002/cmdc.201402409. Epub 2014 Dec 23.

PMID:
25537267
14.

Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.

Chen Y, Sun J, Fang L, Liu M, Peng S, Liao H, Lehmann J, Zhang Y.

J Med Chem. 2012 May 10;55(9):4309-21. doi: 10.1021/jm300106z. Epub 2012 Apr 27.

PMID:
22512543
15.

Cudarflavone B provides neuroprotection against glutamate-induced mouse hippocampal HT22 cell damage through the Nrf2 and PI3K/Akt signaling pathways.

Lee DS, Ko W, Kim DC, Kim YC, Jeong GS.

Molecules. 2014 Jul 24;19(8):10818-31. doi: 10.3390/molecules190810818.

16.

The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice.

Hong Y, Yan W, Chen S, Sun CR, Zhang JM.

Acta Pharmacol Sin. 2010 Nov;31(11):1421-30. doi: 10.1038/aps.2010.101. Epub 2010 Oct 18.

17.

Effect of 7, 8-dihydroxyflavone on the up-regulation of Nrf2-mediated heme oxygenase-1 expression in hamster lung fibroblasts.

Ryu MJ, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Chung HS, Park JC, Cho SJ, Hyun JW.

In Vitro Cell Dev Biol Anim. 2014 Jun;50(6):549-54. doi: 10.1007/s11626-014-9735-4. Epub 2014 Mar 8.

PMID:
24610348
18.

2-Ethoxy-4,5-diphenyl-1,3-oxazine-6-one activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.

Ansari N, Khodagholi F, Amini M.

Eur J Pharmacol. 2011 May 11;658(2-3):84-90. doi: 10.1016/j.ejphar.2011.02.028. Epub 2011 Mar 1.

PMID:
21371450
19.

Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner.

Hwang YP, Kim HG, Han EH, Jeong HG.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):318-27. doi: 10.1016/j.taap.2008.04.019. Epub 2008 May 2.

PMID:
18554677
20.

Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.

Chao X, He X, Yang Y, Zhou X, Jin M, Liu S, Cheng Z, Liu P, Wang Y, Yu J, Tan Y, Huang Y, Qin J, Rapposelli S, Pi R.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6498-502. doi: 10.1016/j.bmcl.2012.08.036. Epub 2012 Aug 16.

PMID:
22981331

Supplemental Content

Support Center