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High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.

Lera RF, Burkard ME.

J Biol Chem. 2012 Dec 14;287(51):42812-25. doi: 10.1074/jbc.M112.412544. Epub 2012 Oct 27.


Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus.

Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, Menendez JA.

Cell Cycle. 2011 Apr 15;10(8):1295-302. Epub 2011 Apr 15.


Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting.

Hanisch A, Wehner A, Nigg EA, Silljé HH.

Mol Biol Cell. 2006 Jan;17(1):448-59. Epub 2005 Nov 2.


The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation.

Lasek AL, McPherson BM, Trueman NG, Burkard ME.

PLoS One. 2016 Feb 26;11(2):e0150225. doi: 10.1371/journal.pone.0150225. eCollection 2016.


PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity.

Zhang L, Shao H, Huang Y, Yan F, Chu Y, Hou H, Zhu M, Fu C, Aikhionbare F, Fang G, Ding X, Yao X.

J Biol Chem. 2011 Jan 28;286(4):3033-46. doi: 10.1074/jbc.M110.165340. Epub 2010 Nov 15.


Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.

Yim H, Erikson RL.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19742-7. doi: 10.1073/pnas.1013557107. Epub 2010 Nov 1.


Polo-like kinase controls vertebrate spindle elongation and cytokinesis.

Brennan IM, Peters U, Kapoor TM, Straight AF.

PLoS One. 2007 May 2;2(5):e409.


Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation.

Kang YH, Park JE, Yu LR, Soung NK, Yun SM, Bang JK, Seong YS, Yu H, Garfield S, Veenstra TD, Lee KS.

Mol Cell. 2006 Nov 3;24(3):409-22.


Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis.

van Vugt MA, van de Weerdt BC, Vader G, Janssen H, Calafat J, Klompmaker R, Wolthuis RM, Medema RH.

J Biol Chem. 2004 Aug 27;279(35):36841-54. Epub 2004 Jun 21.


The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation.

Liu J, Zhang C.

Cell Mol Life Sci. 2017 Jun;74(12):2127-2134. doi: 10.1007/s00018-017-2457-5. Epub 2017 Feb 10. Review.


PLK1 regulates spindle formation kinetics and APC/C activation in mouse zygote.

Baran V, Brzakova A, Rehak P, Kovarikova V, Solc P.

Zygote. 2016 Jun;24(3):338-45. doi: 10.1017/S0967199415000246. Epub 2015 Jul 15.


Roles of polo-like kinase 1 in the assembly of functional mitotic spindles.

Sumara I, Giménez-Abián JF, Gerlich D, Hirota T, Kraft C, de la Torre C, Ellenberg J, Peters JM.

Curr Biol. 2004 Oct 5;14(19):1712-22.


The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1.

Ritter A, Sanhaji M, Steinhäuser K, Roth S, Louwen F, Yuan J.

Oncotarget. 2015 Mar 30;6(9):6641-55.


A spindle checkpoint arrest and a cytokinesis failure by the dominant-negative polo-box domain of Plk1 in U-2 OS cells.

Seong YS, Kamijo K, Lee JS, Fernandez E, Kuriyama R, Miki T, Lee KS.

J Biol Chem. 2002 Aug 30;277(35):32282-93. Epub 2002 May 28.


Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.

Shao H, Huang Y, Zhang L, Yuan K, Chu Y, Dou Z, Jin C, Garcia-Barrio M, Liu X, Yao X.

Sci Rep. 2015 Jul 24;5:12204. doi: 10.1038/srep12204.


Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.

Ikeda M, Chiba S, Ohashi K, Mizuno K.

J Biol Chem. 2012 Aug 10;287(33):27670-81. doi: 10.1074/jbc.M112.378968. Epub 2012 Jun 29.


P21-activated kinase is required for mitotic progression and regulates Plk1.

Maroto B, Ye MB, von Lohneysen K, Schnelzer A, Knaus UG.

Oncogene. 2008 Aug 21;27(36):4900-8. doi: 10.1038/onc.2008.131. Epub 2008 Apr 21.


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