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Interleukin 1β regulation of FoxO1 protein content and localization: evidence for a novel ceramide-dependent mechanism.

Dobierzewska A, Shi L, Karakashian AA, Nikolova-Karakashian MN.

J Biol Chem. 2012 Dec 28;287(53):44749-60. doi: 10.1074/jbc.M112.378836. Epub 2012 Oct 26.


Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation.

Karakashian AA, Giltiay NV, Smith GM, Nikolova-Karakashian MN.

FASEB J. 2004 Jun;18(9):968-70. Epub 2004 Apr 1.


Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta.

Dobierzewska A, Giltiay NV, Sabapathi S, Karakashian AA, Nikolova-Karakashian MN.

J Biol Chem. 2011 Sep 16;286(37):32064-73. doi: 10.1074/jbc.M111.238030. Epub 2011 Jun 27.


Ceramide- and ERK-dependent pathway for the activation of CCAAT/enhancer binding protein by interleukin-1beta in hepatocytes.

Giltiay NV, Karakashian AA, Alimov AP, Ligthle S, Nikolova-Karakashian MN.

J Lipid Res. 2005 Nov;46(11):2497-505. Epub 2005 Aug 16.


Aging in rat causes hepatic hyperresposiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2.

Rutkute K, Karakashian AA, Giltiay NV, Dobierzewska A, Nikolova-Karakashian MN.

Hepatology. 2007 Oct;46(4):1166-76.


Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).

Meur G, Qian Q, da Silva Xavier G, Pullen TJ, Tsuboi T, McKinnon C, Fletcher L, Tavaré JM, Hughes S, Johnson P, Rutter GA.

J Biol Chem. 2011 Apr 15;286(15):13647-56. doi: 10.1074/jbc.M110.204248. Epub 2011 Feb 18.


Macrophage CGI-58 deficiency promotes IL-1β transcription by activating the SOCS3-FOXO1 pathway.

Miao H, Ou J, Zhang X, Chen Y, Xue B, Shi H, Gan L, Yu L, Liang H.

Clin Sci (Lond). 2015 Apr;128(8):493-506. doi: 10.1042/CS20140414.


Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway.

Liu HY, Wen GB, Han J, Hong T, Zhuo D, Liu Z, Cao W.

J Biol Chem. 2008 Nov 7;283(45):30642-9. doi: 10.1074/jbc.M803698200. Epub 2008 Sep 11.


FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages.

Su D, Coudriet GM, Hyun Kim D, Lu Y, Perdomo G, Qu S, Slusher S, Tse HM, Piganelli J, Giannoukakis N, Zhang J, Dong HH.

Diabetes. 2009 Nov;58(11):2624-33. doi: 10.2337/db09-0232. Epub 2009 Aug 3.


Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction.

Meng Z, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X.

Endocrinology. 2009 Dec;150(12):5284-93. doi: 10.1210/en.2009-0671. Epub 2009 Oct 16.


Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation.

Rutkute K, Asmis RH, Nikolova-Karakashian MN.

J Lipid Res. 2007 Nov;48(11):2443-52. Epub 2007 Aug 10.


PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle.

Southgate RJ, Bruce CR, Carey AL, Steinberg GR, Walder K, Monks R, Watt MJ, Hawley JA, Birnbaum MJ, Febbraio MA.

FASEB J. 2005 Dec;19(14):2072-4. Epub 2005 Oct 3. Retraction in: FASEB J. 2009 Aug;23(8):2790.


Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.

Naïmi M, Gautier N, Chaussade C, Valverde AM, Accili D, Van Obberghen E.

Endocrinology. 2007 May;148(5):2424-34. Epub 2007 Feb 15. Erratum in: Endocrinology. 2007 Jul;148(7):3517.


Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis.

Jiao P, Feng B, Xu H.

PLoS One. 2012;7(7):e41168. doi: 10.1371/journal.pone.0041168. Epub 2012 Jul 25.


Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1.

Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ.

Nat Med. 2012 Feb 19;18(3):388-95. doi: 10.1038/nm.2686.


Protein kinase Cδ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3ζ.

Gerst F, Kaiser G, Panse M, Sartorius T, Pujol A, Hennige AM, Machicao F, Lammers R, Bosch F, Häring HU, Ullrich S.

Diabetologia. 2015 Dec;58(12):2819-31. doi: 10.1007/s00125-015-3744-z. Epub 2015 Sep 12.


Modulation of FoxO1 phosphorylation/acetylation by baicalin during aging.

Kim DH, Kim JM, Lee EK, Choi YJ, Kim CH, Choi JS, Kim ND, Yu BP, Chung HY.

J Nutr Biochem. 2012 Oct;23(10):1277-84. doi: 10.1016/j.jnutbio.2011.07.008. Epub 2011 Dec 29.


Insulin regulation of gene expression through the forkhead transcription factor Foxo1 (Fkhr) requires kinases distinct from Akt.

Nakae J, Kitamura T, Ogawa W, Kasuga M, Accili D.

Biochemistry. 2001 Oct 2;40(39):11768-76.


The role of FoxO1 in interleukin-1β-induced autostimulation in retina endothelial cells and retinas of diabetic rats.

Wu L, Guo F, Wu Y, Wang Q, Ma X, Zhao Y, Qin G.

Microvasc Res. 2017 Jul;112:93-100. doi: 10.1016/j.mvr.2017.03.003. Epub 2017 Mar 7.


TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.

Moylan JS, Smith JD, Chambers MA, McLoughlin TJ, Reid MB.

Am J Physiol Cell Physiol. 2008 Oct;295(4):C986-93. doi: 10.1152/ajpcell.00041.2008. Epub 2008 Aug 13.

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