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Items: 1 to 20 of 177

1.

Dsc orthologs are required for hypoxia adaptation, triazole drug responses, and fungal virulence in Aspergillus fumigatus.

Willger SD, Cornish EJ, Chung D, Fleming BA, Lehmann MM, Puttikamonkul S, Cramer RA.

Eukaryot Cell. 2012 Dec;11(12):1557-67. doi: 10.1128/EC.00252-12. Epub 2012 Oct 26.

2.

Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.

Vaknin Y, Hillmann F, Iannitti R, Ben Baruch N, Sandovsky-Losica H, Shadkchan Y, Romani L, Brakhage A, Kniemeyer O, Osherov N.

Infect Immun. 2016 May 24;84(6):1866-78. doi: 10.1128/IAI.00011-16. Print 2016 Jun.

3.

ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence.

Chung D, Barker BM, Carey CC, Merriman B, Werner ER, Lechner BE, Dhingra S, Cheng C, Xu W, Blosser SJ, Morohashi K, Mazurie A, Mitchell TK, Haas H, Mitchell AP, Cramer RA.

PLoS Pathog. 2014 Nov 6;10(11):e1004487. doi: 10.1371/journal.ppat.1004487. eCollection 2014 Nov. Erratum in: PLoS Pathog. 2014 Nov;10(11):e1004576.

4.

A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

Willger SD, Puttikamonkul S, Kim KH, Burritt JB, Grahl N, Metzler LJ, Barbuch R, Bard M, Lawrence CB, Cramer RA Jr.

PLoS Pathog. 2008 Nov;4(11):e1000200. doi: 10.1371/journal.ppat.1000200. Epub 2008 Nov 7.

5.

SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).

Blosser SJ, Cramer RA.

Antimicrob Agents Chemother. 2012 Jan;56(1):248-57. doi: 10.1128/AAC.05027-11. Epub 2011 Oct 17.

6.

SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus.

Blatzer M, Barker BM, Willger SD, Beckmann N, Blosser SJ, Cornish EJ, Mazurie A, Grahl N, Haas H, Cramer RA.

PLoS Genet. 2011 Dec;7(12):e1002374. doi: 10.1371/journal.pgen.1002374. Epub 2011 Dec 1.

7.

The signal peptide peptidase SppA is involved in sterol regulatory element-binding protein cleavage and hypoxia adaptation in Aspergillus nidulans.

Bat-Ochir C, Kwak JY, Koh SK, Jeon MH, Chung D, Lee YW, Chae SK.

Mol Microbiol. 2016 May;100(4):635-55. doi: 10.1111/mmi.13341. Epub 2016 Mar 2.

PMID:
26822492
8.

Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

Lloyd SJ, Raychaudhuri S, Espenshade PJ.

J Biol Chem. 2013 Jul 19;288(29):21043-54. doi: 10.1074/jbc.M113.468215. Epub 2013 Jun 12.

9.

RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus.

Dhingra S, Kowlaski CH, Thammahong A, Beattie SR, Bultman KM, Cramer RA.

mSphere. 2016 Mar 2;1(2). pii: e00035-16. doi: 10.1128/mSphere.00035-16. eCollection 2016 Mar-Apr.

10.

Effects of a defective endoplasmic reticulum-associated degradation pathway on the stress response, virulence, and antifungal drug susceptibility of the mold pathogen Aspergillus fumigatus.

Krishnan K, Feng X, Powers-Fletcher MV, Bick G, Richie DL, Woollett LA, Askew DS.

Eukaryot Cell. 2013 Apr;12(4):512-9. doi: 10.1128/EC.00319-12. Epub 2013 Jan 25.

11.

Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

Cheung R, Espenshade PJ.

J Biol Chem. 2013 Jul 12;288(28):20351-60. doi: 10.1074/jbc.M113.482224. Epub 2013 May 31.

12.

Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus.

Blosser SJ, Merriman B, Grahl N, Chung D, Cramer RA.

Microbiology. 2014 Nov;160(Pt 11):2492-506. doi: 10.1099/mic.0.080440-0. Epub 2014 Aug 8.

13.

Damage resistance protein (Dap) contributes to azole resistance in a sterol-regulatory-element-binding protein SrbA-dependent way.

Song J, Zhai P, Lu L.

Appl Microbiol Biotechnol. 2017 May;101(9):3729-3741. doi: 10.1007/s00253-016-8072-9. Epub 2017 Jan 3.

PMID:
28050634
14.

Endoplasmic reticulum localized PerA is required for cell wall integrity, azole drug resistance, and virulence in Aspergillus fumigatus.

Chung D, Thammahong A, Shepardson KM, Blosser SJ, Cramer RA.

Mol Microbiol. 2014 Jun;92(6):1279-98. doi: 10.1111/mmi.12626. Epub 2014 May 9.

15.

The three Aspergillus fumigatus CFEM-domain GPI-anchored proteins (CfmA-C) affect cell-wall stability but do not play a role in fungal virulence.

Vaknin Y, Shadkchan Y, Levdansky E, Morozov M, Romano J, Osherov N.

Fungal Genet Biol. 2014 Feb;63:55-64. doi: 10.1016/j.fgb.2013.12.005. Epub 2013 Dec 20.

PMID:
24361821
16.

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ.

PLoS Pathog. 2016 Jul 20;12(7):e1005775. doi: 10.1371/journal.ppat.1005775. eCollection 2016 Jul. Erratum in: PLoS Pathog. 2016 Dec 14;12 (12 ):e1006106.

17.

Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter.

Barker BM, Kroll K, Vödisch M, Mazurie A, Kniemeyer O, Cramer RA.

BMC Genomics. 2012 Feb 6;13:62. doi: 10.1186/1471-2164-13-62.

18.

The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus.

Kroll K, Shekhova E, Mattern DJ, Thywissen A, Jacobsen ID, Strassburger M, Heinekamp T, Shelest E, Brakhage AA, Kniemeyer O.

Mol Microbiol. 2016 Jul;101(1):92-108. doi: 10.1111/mmi.13377. Epub 2016 May 3.

PMID:
26991818
19.

The Aspergillus fumigatus pkcA G579R Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model.

Rocha MC, Godoy KF, de Castro PA, Hori JI, Bom VL, Brown NA, Cunha AF, Goldman GH, Malavazi I.

PLoS One. 2015 Aug 21;10(8):e0135195. doi: 10.1371/journal.pone.0135195. eCollection 2015.

20.

cipC is important for Aspergillus fumigatus virulence.

Canela HM, Takami LA, da Silva Ferreira ME.

APMIS. 2017 Feb;125(2):141-147. doi: 10.1111/apm.12648.

PMID:
28120495

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