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Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc.

Hayes AJ, Smith SM, Melrose J.

Histochem Cell Biol. 2013 Jan;139(1):1-11. doi: 10.1007/s00418-012-1041-1. Epub 2012 Oct 27.


Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix.

Hayes AJ, Gibson MA, Shu C, Melrose J.

Tissue Cell. 2014 Jun;46(3):185-97. doi: 10.1016/j.tice.2014.04.002. Epub 2014 May 6.


The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-β1 in skin compared to C57BL/6 wild type mice.

Shu C, Smith SM, Melrose J.

J Mol Histol. 2016 Jun;47(3):365-74. doi: 10.1007/s10735-016-9677-0. Epub 2016 Apr 21.


The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc.

Shu C, Hughes C, Smith SM, Smith MM, Hayes A, Caterson B, Little CB, Melrose J.

Glycoconj J. 2013 Oct;30(7):717-25. doi: 10.1007/s10719-013-9475-9. Epub 2013 Jun 13.


Colocalization in vivo and association in vitro of perlecan and elastin.

Hayes AJ, Lord MS, Smith SM, Smith MM, Whitelock JM, Weiss AS, Melrose J.

Histochem Cell Biol. 2011 Oct;136(4):437-54. doi: 10.1007/s00418-011-0854-7. Epub 2011 Aug 28.


Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development.

Smith SM, Whitelock JM, Iozzo RV, Little CB, Melrose J.

Histochem Cell Biol. 2009 Nov;132(5):491-503. doi: 10.1007/s00418-009-0623-z. Epub 2009 Aug 11.


The distribution of fibrillin-2 and LTBP-2, and their co-localisation with fibrillin-1 in adult bovine tail disc.

Li B, Urban JP, Yu J.

J Anat. 2012 Feb;220(2):164-72. doi: 10.1111/j.1469-7580.2011.01455.x. Epub 2011 Nov 20.


Absence of biglycan accelerates the degenerative process in mouse intervertebral disc.

Furukawa T, Ito K, Nuka S, Hashimoto J, Takei H, Takahara M, Ogino T, Young MF, Shinomura T.

Spine (Phila Pa 1976). 2009 Dec 1;34(25):E911-7. doi: 10.1097/BRS.0b013e3181b7c7ec.


Microfibrils at basement membrane zones interact with perlecan via fibrillin-1.

Tiedemann K, Sasaki T, Gustafsson E, Göhring W, Bätge B, Notbohm H, Timpl R, Wedel T, Schlötzer-Schrehardt U, Reinhardt DP.

J Biol Chem. 2005 Mar 25;280(12):11404-12. Epub 2005 Jan 17.


Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc.

Yu J, Tirlapur U, Fairbank J, Handford P, Roberts S, Winlove CP, Cui Z, Urban J.

J Anat. 2007 Apr;210(4):460-71.


Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities.

Mátés L, Nicolae C, Mörgelin M, Deák F, Kiss I, Aszódi A.

Matrix Biol. 2004 Jun;23(3):195-204.


Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration.

Melrose J, Shu C, Young C, Ho R, Smith MM, Young AA, Smith SS, Gooden B, Dart A, Podadera J, Appleyard RC, Little CB.

Spine (Phila Pa 1976). 2012 Jan 1;37(1):18-25. doi: 10.1097/BRS.0b013e31820cd8d5.


Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc.

Hayes AJ, Shu CC, Lord MS, Little CB, Whitelock JM, Melrose J.

Eur Cell Mater. 2016 Jul 5;32:40-57.


Intervertebral disc development is regulated by Wnt/β-catenin signaling.

Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, Yasuhara R, Pacifici M, Zhang Y, Iwamoto M, Enomoto-Iwamoto M.

Spine (Phila Pa 1976). 2011 Apr 15;36(8):E513-8. doi: 10.1097/BRS.0b013e3181f52cb5.


Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation.

Fujita K, Ando T, Ohba T, Wako M, Sato N, Nakamura Y, Ohnuma Y, Hara Y, Kato R, Nakao A, Haro H.

J Orthop Res. 2012 Apr;30(4):599-605. doi: 10.1002/jor.21560. Epub 2011 Sep 16.


Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.

Shu CC, Jackson MT, Smith MM, Smith SM, Penm S, Lord MS, Whitelock JM, Little CB, Melrose J.

Arthritis Rheumatol. 2016 Apr;68(4):868-79. doi: 10.1002/art.39529.


Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2.

Bedore J, Sha W, McCann MR, Liu S, Leask A, Séguin CA.

Arthritis Rheum. 2013 Oct;65(10):2634-44. doi: 10.1002/art.38075.

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