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Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone.

Brookes ZL, Ruff L, Upadhyay VS, Huang L, Prasad S, Solanky T, Nauli SM, Ong AC.

Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H33-41. doi: 10.1152/ajpheart.01102.2011. Epub 2012 Oct 26.


Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress.

Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD.

Am J Physiol Heart Circ Physiol. 2016 Jan 1;310(1):H39-48. doi: 10.1152/ajpheart.00490.2015. Epub 2015 Nov 13.


Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress.

Chen Y, Pearlman A, Luo Z, Wilcox CS.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2085-92. Epub 2007 Jul 20.


Metformin protects endothelial function in diet-induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway.

Cheang WS, Tian XY, Wong WT, Lau CW, Lee SS, Chen ZY, Yao X, Wang N, Huang Y.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):830-6. doi: 10.1161/ATVBAHA.113.301938. Epub 2014 Jan 30.


Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitrite.

Huang J, Lin SC, Nadershahi A, Watts SW, Sarkar R.

J Vasc Surg. 2008 Mar;47(3):599-607. doi: 10.1016/j.jvs.2007.11.006.


High salt intake reduces endothelium-dependent dilation of mouse arterioles via superoxide anion generated from nitric oxide synthase.

Nurkiewicz TR, Boegehold MA.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1550-6. Epub 2006 Nov 30.


Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production.

Kleinhenz JM, Kleinhenz DJ, You S, Ritzenthaler JD, Hansen JM, Archer DR, Sutliff RL, Hart CM.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1647-54. doi: 10.1152/ajpheart.00148.2009. Epub 2009 Aug 7.


Ramipril improves oxidative stress-related vascular endothelial dysfunction in db/db mice.

Liang W, Tan CY, Ang L, Sallam N, Granville DJ, Wright JM, Laher I.

J Physiol Sci. 2008 Dec;58(6):405-11. doi: 10.2170/physiolsci.RP012808.


Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.

Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X, Huang Y.

Cardiovasc Res. 2011 Nov 1;92(2):267-75. doi: 10.1093/cvr/cvr233. Epub 2011 Aug 29.


Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.

Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1486-94. doi: 10.1161/ATVBAHA.114.303678. Epub 2014 May 1.


Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades.

AbouAlaiwi WA, Takahashi M, Mell BR, Jones TJ, Ratnam S, Kolb RJ, Nauli SM.

Circ Res. 2009 Apr 10;104(7):860-9. doi: 10.1161/CIRCRESAHA.108.192765. Epub 2009 Mar 5.


Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone.

Sorrentino SA, Bahlmann FH, Besler C, Müller M, Schulz S, Kirchhoff N, Doerries C, Horváth T, Limbourg A, Limbourg F, Fliser D, Haller H, Drexler H, Landmesser U.

Circulation. 2007 Jul 10;116(2):163-73. Epub 2007 Jun 25.


Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, induces dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.

Omae T, Nagaoka T, Tanano I, Yoshida A.

Invest Ophthalmol Vis Sci. 2011 Aug 24;52(9):6749-56. doi: 10.1167/iovs.10-6826.


Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.

d'Uscio LV, Das P, Santhanam AV, He T, Younkin SG, Katusic ZS.

Cardiovasc Res. 2012 Dec 1;96(3):504-12. doi: 10.1093/cvr/cvs266. Epub 2012 Aug 10.


VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice.

Amura CR, Brodsky KS, Groff R, Gattone VH, Voelkel NF, Doctor RB.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C419-28. Epub 2007 May 2.


Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.

Yang J, Park Y, Zhang H, Gao X, Wilson E, Zimmer W, Abbott L, Zhang C.

Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1208-16. doi: 10.1152/ajpheart.00396.2009. Epub 2009 Aug 7.


Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene.

d'Uscio LV, He T, Santhanam AV, Tai LJ, Evans RM, Katusic ZS.

Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H1001-10. doi: 10.1152/ajpheart.00761.2013. Epub 2014 Jan 31.


Angiotensin II infusion alters vascular function in mouse resistance vessels: roles of O and endothelium.

Wang D, Chabrashvili T, Borrego L, Aslam S, Umans JG.

J Vasc Res. 2006;43(1):109-19. Epub 2005 Dec 6.


Contrasting vascular effects caused by loss of Bardet-Biedl syndrome genes.

Beyer AM, Guo DF, Sheffield VC, Rahmouni K.

Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1902-7. doi: 10.1152/ajpheart.00336.2010. Epub 2010 Sep 17.

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