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The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy.

Yu S, Zhou X, Steinke FC, Liu C, Chen SC, Zagorodna O, Jing X, Yokota Y, Meyerholz DK, Mullighan CG, Knudson CM, Zhao DM, Xue HH.

Immunity. 2012 Nov 16;37(5):813-26. doi: 10.1016/j.immuni.2012.08.009. Epub 2012 Oct 25. Erratum in: Immunity. 2014 Jan 16;40(1):166.


TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.

Steinke FC, Yu S, Zhou X, He B, Yang W, Zhou B, Kawamoto H, Zhu J, Tan K, Xue HH.

Nat Immunol. 2014 Jul;15(7):646-56. doi: 10.1038/ni.2897. Epub 2014 May 18.


A critical role for TCF-1 in T-lineage specification and differentiation.

Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O, Bhandoola A.

Nature. 2011 Aug 3;476(7358):63-8. doi: 10.1038/nature10279.


Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.

Shields BJ, Alserihi R, Nasa C, Bogue C, Alexander WS, McCormack MP.

Leukemia. 2015 Apr;29(4):927-38. doi: 10.1038/leu.2014.292. Epub 2014 Oct 6.


T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Wang R, Xie H, Huang Z, Ma J, Fang X, Ding Y, Sun Z.

J Immunol. 2011 Dec 1;187(11):5964-73. doi: 10.4049/jimmunol.1101205. Epub 2011 Oct 28.


Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling.

Maier E, Hebenstreit D, Posselt G, Hammerl P, Duschl A, Horejs-Hoeck J.

J Biol Chem. 2011 Jan 14;286(2):919-28. doi: 10.1074/jbc.M110.144949. Epub 2010 Oct 27.


Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1.

Okamura RM, Sigvardsson M, Galceran J, Verbeek S, Clevers H, Grosschedl R.

Immunity. 1998 Jan;8(1):11-20.


T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development.

Sharma A, Berga-Bolaños R, Sen JM.

PLoS One. 2014 Dec 23;9(12):e115803. doi: 10.1371/journal.pone.0115803. eCollection 2014.


IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1, and RORgammat: impact on thymocyte development.

Yu Q, Erman B, Park JH, Feigenbaum L, Singer A.

J Exp Med. 2004 Sep 20;200(6):797-803. Epub 2004 Sep 13.


Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors.

Klingel S, Morath I, Strietz J, Menzel K, Holstein TW, Gradl D.

Dev Biol. 2012 Aug 1;368(1):44-53. doi: 10.1016/j.ydbio.2012.05.012. Epub 2012 May 26.


Transcriptional regulation of CD4 gene expression by T cell factor-1/beta-catenin pathway.

Huang Z, Xie H, Ioannidis V, Held W, Clevers H, Sadim MS, Sun Z.

J Immunol. 2006 Apr 15;176(8):4880-7.


Overexpression of ICAT highlights a role for catenin-mediated canonical Wnt signalling in early T cell development.

Pongracz JE, Parnell SM, Jones T, Anderson G, Jenkinson EJ.

Eur J Immunol. 2006 Sep;36(9):2376-83.


The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ.

PLoS Biol. 2012;10(11):e1001430. doi: 10.1371/journal.pbio.1001430. Epub 2012 Nov 20.


LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.

Choi YS, Gullicksrud JA, Xing S, Zeng Z, Shan Q, Li F, Love PE, Peng W, Xue HH, Crotty S.

Nat Immunol. 2015 Sep;16(9):980-90. doi: 10.1038/ni.3226. Epub 2015 Jul 27.

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