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Reperfusion therapy in unclear-onset stroke based on MRI evaluation (RESTORE): a prospective multicenter study.

Kang DW, Sohn SI, Hong KS, Yu KH, Hwang YH, Han MK, Lee J, Park JM, Cho AH, Kim HJ, Kim DE, Cho YJ, Koo J, Yun SC, Kwon SU, Bae HJ, Kim JS.

Stroke. 2012 Dec;43(12):3278-83. doi: 10.1161/STROKEAHA.112.675926. Epub 2012 Oct 23.


Pretreatment diffusion-weighted imaging lesion volume predicts favorable outcome after intravenous thrombolysis with tissue-type plasminogen activator in acute ischemic stroke.

Kruetzelmann A, Köhrmann M, Sobesky J, Cheng B, Rosenkranz M, Röther J, Schellinger PD, Ringleb P, Gerloff C, Fiehler J, Thomalla G.

Stroke. 2011 May;42(5):1251-4. doi: 10.1161/STROKEAHA.110.600148. Epub 2011 Mar 17.


MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1210 patients.

Schellinger PD, Thomalla G, Fiehler J, Köhrmann M, Molina CA, Neumann-Haefelin T, Ribo M, Singer OC, Zaro-Weber O, Sobesky J.

Stroke. 2007 Oct;38(10):2640-5. Epub 2007 Aug 16.


Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke.

Higashida RT, Furlan AJ, Roberts H, Tomsick T, Connors B, Barr J, Dillon W, Warach S, Broderick J, Tilley B, Sacks D; Technology Assessment Committee of the American Society of Interventional and Therapeutic Neuroradiology; Technology Assessment Committee of the Society of Interventional Radiology.

Stroke. 2003 Aug;34(8):e109-37. Epub 2003 Jul 17. Erratum in: Stroke. 2003 Nov;34(11):2774.


Bridging intravenous-intra-arterial rescue strategy increases recanalization and the likelihood of a good outcome in nonresponder intravenous tissue plasminogen activator-treated patients: a case-control study.

Rubiera M, Ribo M, Pagola J, Coscojuela P, Rodriguez-Luna D, Maisterra O, Ibarra B, Piñeiro S, Meler P, Romero FJ, Alvarez-Sabin J, Molina CA.

Stroke. 2011 Apr;42(4):993-7. doi: 10.1161/STROKEAHA.110.597104. Epub 2011 Mar 3.


Clinical and magnetic resonance imaging predictors of very early neurological response to intravenous thrombolysis in patients with middle cerebral artery occlusion.

Apoil M, Turc G, Tisserand M, Calvet D, Naggara O, Domigo V, Baron JC, Oppenheim C, Touzé E.

J Am Heart Assoc. 2013 Dec 5;2(6):e000511. doi: 10.1161/JAHA.113.000511.


Validation of FLAIR hyperintense lesions as imaging biomarkers to predict the outcome of acute stroke after intra-arterial thrombolysis following intravenous tissue plasminogen activator.

Chung JW, Kim KJ, Noh WY, Jang MS, Yang MH, Han MK, Kwon OK, Jung C, Kim JH, Oh CW, Lee JS, Lee J, Bae HJ.

Cerebrovasc Dis. 2013;35(5):461-8. doi: 10.1159/000350201. Epub 2013 May 31.


A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND).

Ma H, Parsons MW, Christensen S, Campbell BC, Churilov L, Connelly A, Yan B, Bladin C, Phan T, Barber AP, Read S, Hankey GJ, Markus R, Wijeratne T, Grimley R, Mahant N, Kleinig T, Sturm J, Lee A, Blacker D, Gerraty R, Krause M, Desmond PM, McBride SJ, Carey L, Howells DW, Hsu CY, Davis SM, Donnan GA; EXTEND investigators.

Int J Stroke. 2012 Jan;7(1):74-80. doi: 10.1111/j.1747-4949.2011.00730.x.


Safety and feasibility of intraarterial eptifibatide as a revascularization tool in acute ischemic stroke.

Memon MZ, Natarajan SK, Sharma J, Mathews MS, Snyder KV, Siddiqui AH, Hopkins LN, Levy EI.

J Neurosurg. 2011 Apr;114(4):1008-13. doi: 10.3171/2010.8.JNS10318. Epub 2010 Sep 24.


Worse stroke outcome in atrial fibrillation is explained by more severe hypoperfusion, infarct growth, and hemorrhagic transformation.

Tu HT, Campbell BC, Christensen S, Desmond PM, De Silva DA, Parsons MW, Churilov L, Lansberg MG, Mlynash M, Olivot JM, Straka M, Bammer R, Albers GW, Donnan GA, Davis SM; EPITHET-DEFUSE Investigators.

Int J Stroke. 2015 Jun;10(4):534-40. doi: 10.1111/ijs.12007. Epub 2013 Mar 12.


Stroke lesion volumes and outcome are not different in hemispheric stroke side treated with intravenous thrombolysis based on magnetic resonance imaging criteria.

Golsari A, Cheng B, Sobesky J, Schellinger PD, Fiehler J, Gerloff C, Thomalla G.

Stroke. 2015 Apr;46(4):1004-8. doi: 10.1161/STROKEAHA.114.007292. Epub 2015 Feb 19.


Wake-up stroke within 3 hours of symptom awareness: imaging and clinical features compared to standard recombinant tissue plasminogen activator treated stroke.

Roveri L, La Gioia S, Ghidinelli C, Anzalone N, De Filippis C, Comi G.

J Stroke Cerebrovasc Dis. 2013 Aug;22(6):703-8. doi: 10.1016/j.jstrokecerebrovasdis.2011.10.003. Epub 2011 Nov 30.


Systematic review of outcome after ischemic stroke due to anterior circulation occlusion treated with intravenous, intra-arterial, or combined intravenous+intra-arterial thrombolysis.

Mullen MT, Pisapia JM, Tilwa S, Messé SR, Stein SC.

Stroke. 2012 Sep;43(9):2350-5. doi: 10.1161/STROKEAHA.111.639211. Epub 2012 Jul 17. Review.


Combined intravenous and intraarterial revascularization therapy using MRI perfusion/diffusion mismatch selection for acute ischemic stroke at 3-6 h after symptom onset.

Han MK, Kim SH, Ko SB, Paik NJ, Kwon OK, Lee YS, Oh CW, Kim JH, Park SH, Bae HJ.

Neurocrit Care. 2008;8(3):353-9. doi: 10.1007/s12028-007-9046-7.


Intravenous tissue plasminogen activator for patients with minor ischemic stroke.

Huisa BN, Raman R, Neil W, Ernstrom K, Hemmen TM.

J Stroke Cerebrovasc Dis. 2012 Nov;21(8):732-6. doi: 10.1016/j.jstrokecerebrovasdis.2011.03.009. Epub 2011 Apr 30.


A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits with Intra-Arterial therapy (EXTEND-IA).

Campbell BC, Mitchell PJ, Yan B, Parsons MW, Christensen S, Churilov L, Dowling RJ, Dewey H, Brooks M, Miteff F, Levi C, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Kleinig T, Scroop R, Chryssidis S, Barber A, Hope A, Moriarty M, McGuinness B, Wong AA, Coulthard A, Wijeratne T, Lee A, Jannes J, Leyden J, Phan TG, Chong W, Holt ME, Chandra RV, Bladin CF, Badve M, Rice H, de Villiers L, Ma H, Desmond PM, Donnan GA, Davis SM; EXTEND-IA investigators.

Int J Stroke. 2014 Jan;9(1):126-32. doi: 10.1111/ijs.12206. Epub 2013 Nov 10.


Immediate changes in stroke lesion volumes post thrombolysis predict clinical outcome.

Luby M, Warach SJ, Nadareishvili Z, Merino JG.

Stroke. 2014 Nov;45(11):3275-9. doi: 10.1161/STROKEAHA.114.006082. Epub 2014 Sep 11.


A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of magnetic resonance imaging-based thrombolysis in wake-up stroke (WAKE-UP).

Thomalla G, Fiebach JB, Østergaard L, Pedraza S, Thijs V, Nighoghossian N, Roy P, Muir KW, Ebinger M, Cheng B, Galinovic I, Cho TH, Puig J, Boutitie F, Simonsen CZ, Endres M, Fiehler J, Gerloff C; WAKE-UP investigators.

Int J Stroke. 2014 Aug;9(6):829-36. doi: 10.1111/ijs.12011. Epub 2013 Mar 12.


Infarct volume is a pivotal biomarker after intra-arterial stroke therapy.

Yoo AJ, Chaudhry ZA, Nogueira RG, Lev MH, Schaefer PW, Schwamm LH, Hirsch JA, González RG.

Stroke. 2012 May;43(5):1323-30. doi: 10.1161/STROKEAHA.111.639401. Epub 2012 Mar 15.


THrombolysis for Acute Wake-up and unclear-onset Strokes with alteplase at 0·6 mg/kg (THAWS) Trial.

Koga M, Toyoda K, Kimura K, Yamamoto H, Sasaki M, Hamasaki T, Kitazono T, Aoki J, Seki K, Homma K, Sato S, Minematsu K; THAWS investigators.

Int J Stroke. 2014 Dec;9(8):1117-24. doi: 10.1111/ijs.12360. Epub 2014 Aug 4.

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