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Items: 1 to 20 of 100

1.

Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.

Mohammed AM, Syeda K, Hadden T, Kowluru A.

Biochem Pharmacol. 2013 Jan 1;85(1):109-14. doi: 10.1016/j.bcp.2012.09.024. Epub 2012 Oct 23.

2.

Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1.

Subasinghe W, Syed I, Kowluru A.

Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R12-20. doi: 10.1152/ajpregu.00421.2010. Epub 2010 Oct 13.

3.

Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1).

Sidarala V, Veluthakal R, Syeda K, Vlaar C, Newsholme P, Kowluru A.

Biochem Pharmacol. 2015 Jun 15;95(4):301-10. doi: 10.1016/j.bcp.2015.04.001. Epub 2015 Apr 14.

PMID:
25881746
4.

Activation of apocynin-sensitive NADPH oxidase (Nox2) activity in INS-1 832/13 cells under glucotoxic conditions.

Mohammed AM, Kowluru A.

Islets. 2013 May-Jun;5(3):129-31. doi: 10.4161/isl.25058. Epub 2013 May 21.

PMID:
23695780
5.

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

Diabetes. 2008 Nov;57(11):3034-44. doi: 10.2337/db07-1802. Epub 2008 Jun 30.

6.

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.

Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco FA, Villate O, Oliveira JM, Casimir M, Bugliani M, Engin F, Hotamisligil GS, Marchetti P, Eizirik DL.

Diabetologia. 2015 Oct;58(10):2307-16. doi: 10.1007/s00125-015-3669-6. Epub 2015 Jun 23.

PMID:
26099855
7.

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells.

Chan JY, Cooney GJ, Biden TJ, Laybutt DR.

Diabetologia. 2011 Jul;54(7):1766-76. doi: 10.1007/s00125-011-2139-z. Epub 2011 Apr 7.

PMID:
21472432
8.
9.

TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells.

Prause M, Berchtold LA, Urizar AI, Hyldgaard Trauelsen M, Billestrup N, Mandrup-Poulsen T, Størling J.

Mol Cell Endocrinol. 2016 Jan 15;420:24-36. doi: 10.1016/j.mce.2015.11.021. Epub 2015 Nov 22.

PMID:
26610752
10.

Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2.

Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI.

Circ Res. 2009 Jan 30;104(2):210-8, 21p following 218. doi: 10.1161/CIRCRESAHA.108.181040. Epub 2008 Dec 18.

11.

Nox2 and Nox4 mediate tumour necrosis factor-α-induced ventricular remodelling in mice.

Moe KT, Yin NO, Naylynn TM, Khairunnisa K, Wutyi MA, Gu Y, Atan MS, Wong MC, Koh TH, Wong P.

J Cell Mol Med. 2011 Dec;15(12):2601-13. doi: 10.1111/j.1582-4934.2011.01261.x.

12.

Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide.

Kacheva S, Lenzen S, Gurgul-Convey E.

Cytokine. 2011 Aug;55(2):195-201. doi: 10.1016/j.cyto.2011.04.002. Epub 2011 Apr 29.

PMID:
21531147
13.

L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells.

Syed I, Szulc ZM, Ogretmen B, Kowluru A.

Cell Physiol Biochem. 2012;30(4):1051-8. doi: 10.1159/000341481. Epub 2012 Sep 24.

14.

Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches.

Kowluru A.

Biochem Pharmacol. 2011 Apr 15;81(8):965-75. doi: 10.1016/j.bcp.2011.01.013. Epub 2011 Feb 12.

15.

Phagocyte-like NADPH oxidase [Nox2] in cellular dysfunction in models of glucolipotoxicity and diabetes.

Kowluru A, Kowluru RA.

Biochem Pharmacol. 2014 Apr 1;88(3):275-83. doi: 10.1016/j.bcp.2014.01.017. Epub 2014 Jan 22.

PMID:
24462914
16.

Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.

Weaver JR, Holman TR, Imai Y, Jadhav A, Kenyon V, Maloney DJ, Nadler JL, Rai G, Simeonov A, Taylor-Fishwick DA.

Mol Cell Endocrinol. 2012 Jul 6;358(1):88-95. doi: 10.1016/j.mce.2012.03.004. Epub 2012 Mar 20.

PMID:
22502743
17.
18.

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells.

Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L, Marchetti P, Haefliger JA, Eizirik DL, Cardozo AK.

Cell Death Differ. 2012 Nov;19(11):1836-46. doi: 10.1038/cdd.2012.67. Epub 2012 Jun 1.

19.

NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model.

Veluthakal R, Sidarala V, Kowluru A.

Cell Physiol Biochem. 2016;39(2):760-7. doi: 10.1159/000445666. Epub 2016 Jul 29.

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