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Evolutionary history of human disease genes reveals phenotypic connections and comorbidity among genetic diseases.

Park S, Yang JS, Kim J, Shin YE, Hwang J, Park J, Jang SK, Kim S.

Sci Rep. 2012;2:757. doi: 10.1038/srep00757. Epub 2012 Oct 22.


Evolutionary conservation and network structure characterize genes of phenotypic relevance for mitosis in human.

Ostaszewski M, Eifes S, del Sol A.

PLoS One. 2012;7(5):e36488. doi: 10.1371/journal.pone.0036488. Epub 2012 May 2.


Inferring gene-phenotype associations via global protein complex network propagation.

Yang P, Li X, Wu M, Kwoh CK, Ng SK.

PLoS One. 2011;6(7):e21502. doi: 10.1371/journal.pone.0021502. Epub 2011 Jul 25.


An ancient evolutionary origin of genes associated with human genetic diseases.

Domazet-Loso T, Tautz D.

Mol Biol Evol. 2008 Dec;25(12):2699-707. doi: 10.1093/molbev/msn214. Epub 2008 Sep 26.


Inverse relationship between evolutionary rate and age of mammalian genes.

Albà MM, Castresana J.

Mol Biol Evol. 2005 Mar;22(3):598-606. Epub 2004 Nov 10. Erratum in: Mol Biol Evol. 2005 Apr;22(4):1159.


Protein localization as a principal feature of the etiology and comorbidity of genetic diseases.

Park S, Yang JS, Shin YE, Park J, Jang SK, Kim S.

Mol Syst Biol. 2011 May 24;7:494. doi: 10.1038/msb.2011.29.


Disease networks. Uncovering disease-disease relationships through the incomplete interactome.

Menche J, Sharma A, Kitsak M, Ghiassian SD, Vidal M, Loscalzo J, Barabási AL.

Science. 2015 Feb 20;347(6224):1257601. doi: 10.1126/science.1257601.


Evolutionary dynamics of co-segregating gene clusters associated with complex diseases.

Preuss C, Riemenschneider M, Wiedmann D, Stoll M.

PLoS One. 2012;7(5):e36205. doi: 10.1371/journal.pone.0036205. Epub 2012 May 14.


Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history.

Nomiyama H, Osada N, Yoshie O.

Genes Cells. 2013 Jan;18(1):1-16. doi: 10.1111/gtc.12013. Epub 2012 Nov 12. Review.


On the origins of Mendelian disease genes in man: the impact of gene duplication.

Dickerson JE, Robertson DL.

Mol Biol Evol. 2012 Jan;29(1):61-9. doi: 10.1093/molbev/msr111. Epub 2011 Jun 24. Erratum in: Mol Biol Evol. 2012 Sep;29(9):2284.


Co-clustering phenome-genome for phenotype classification and disease gene discovery.

Hwang T, Atluri G, Xie M, Dey S, Hong C, Kumar V, Kuang R.

Nucleic Acids Res. 2012 Oct;40(19):e146. doi: 10.1093/nar/gks615. Epub 2012 Jun 26.


Positionally biased gene loss after whole genome duplication: evidence from human, yeast, and plant.

Makino T, McLysaght A.

Genome Res. 2012 Dec;22(12):2427-35. doi: 10.1101/gr.131953.111. Epub 2012 Jul 26.


Ranking candidate disease genes from gene expression and protein interaction: a Katz-centrality based approach.

Zhao J, Yang TH, Huang Y, Holme P.

PLoS One. 2011;6(9):e24306. doi: 10.1371/journal.pone.0024306. Epub 2011 Sep 2.


Interacting gene clusters and the evolution of the vertebrate immune system.

Makino T, McLysaght A.

Mol Biol Evol. 2008 Sep;25(9):1855-62. doi: 10.1093/molbev/msn137. Epub 2008 Jun 23. Erratum in: Mol Biol Evol. 2008 Dec;25(12). doi: 10.1093/molbev/msn241.


Relaxed selection is a precursor to the evolution of phenotypic plasticity.

Hunt BG, Ometto L, Wurm Y, Shoemaker D, Yi SV, Keller L, Goodisman MA.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15936-41. doi: 10.1073/pnas.1104825108. Epub 2011 Sep 12.


Evolutionary mutant models for human disease.

Albertson RC, Cresko W, Detrich HW 3rd, Postlethwait JH.

Trends Genet. 2009 Feb;25(2):74-81. doi: 10.1016/j.tig.2008.11.006. Epub 2008 Dec 26.


Exploring the differences in evolutionary rates between monogenic and polygenic disease genes in human.

Podder S, Ghosh TC.

Mol Biol Evol. 2010 Apr;27(4):934-41. doi: 10.1093/molbev/msp297. Epub 2009 Dec 2. Erratum in: Mol Biol Evol. 2011 Sep;28(9):2719.


Evolutionary signatures amongst disease genes permit novel methods for gene prioritization and construction of informative gene-based networks.

Priedigkeit N, Wolfe N, Clark NL.

PLoS Genet. 2015 Feb 13;11(2):e1004967. doi: 10.1371/journal.pgen.1004967. eCollection 2015 Feb.

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