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Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats.

Panigrahi GB, Slean MM, Simard JP, Pearson CE.

J Biol Chem. 2012 Dec 7;287(50):41844-50. doi: 10.1074/jbc.M112.420398. Epub 2012 Oct 18.


Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.

Panigrahi GB, Slean MM, Simard JP, Gileadi O, Pearson CE.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12593-8. doi: 10.1073/pnas.0909087107. Epub 2010 Jun 22.


N-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalpha.

Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S.

Nucleic Acids Res. 2003 Jun 15;31(12):3217-26.


Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.

Räschle M, Marra G, Nyström-Lahti M, Schär P, Jiricny J.

J Biol Chem. 1999 Nov 5;274(45):32368-75.


Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair.

Panigrahi GB, Lau R, Montgomery SE, Leonard MR, Pearson CE.

Nat Struct Mol Biol. 2005 Aug;12(8):654-62. Epub 2005 Jul 17.


HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.

Jäger AC, Rasmussen M, Bisgaard HC, Singh KK, Nielsen FC, Rasmussen LJ.

Oncogene. 2001 Jun 14;20(27):3590-5.


Oxidative stress inactivates the human DNA mismatch repair system.

Chang CL, Marra G, Chauhan DP, Ha HT, Chang DK, Ricciardiello L, Randolph A, Carethers JM, Boland CR.

Am J Physiol Cell Physiol. 2002 Jul;283(1):C148-54.


Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cells.

Leung WK, Kim JJ, Wu L, Sepulveda JL, Sepulveda AR.

J Biol Chem. 2000 May 26;275(21):15728-32.


Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.

Qi Y, Schoene NW, Lartey FM, Cheng WH.

J Biol Chem. 2010 Oct 22;285(43):33010-7. doi: 10.1074/jbc.M110.137406. Epub 2010 Aug 6.


Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair-deficient tumors.

Hatch SB, Lightfoot HM Jr, Garwacki CP, Moore DT, Calvo BF, Woosley JT, Sciarrotta J, Funkhouser WK, Farber RA.

Clin Cancer Res. 2005 Mar 15;11(6):2180-7.


Alterations of DNA mismatch repair proteins and microsatellite instability levels in gastric cancer cell lines.

Yao Y, Tao H, Kim JJ, Burkhead B, Carloni E, Gasbarrini A, Sepulveda AR.

Lab Invest. 2004 Jul;84(7):915-22.


hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

Plotz G, Raedle J, Brieger A, Trojan J, Zeuzem S.

Nucleic Acids Res. 2002 Feb 1;30(3):711-8.


Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability.

Ma AH, Xia L, Littman SJ, Swinler S, Lader G, Polinkovsky A, Olechnowicz J, Kasturi L, Lutterbaugh J, Modrich P, Veigl ML, Markowitz SD, Sedwick WD.

Oncogene. 2000 Apr 27;19(18):2249-56.


Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks.

Slean MM, Panigrahi GB, Castel AL, Pearson AB, Tomkinson AE, Pearson CE.

DNA Repair (Amst). 2016 Jun;42:107-18. doi: 10.1016/j.dnarep.2016.04.002. Epub 2016 Apr 16.


Interconverting conformations of slipped-DNA junctions formed by trinucleotide repeats affect repair outcome.

Slean MM, Reddy K, Wu B, Nichol Edamura K, Kekis M, Nelissen FH, Aspers RL, Tessari M, Schärer OD, Wijmenga SS, Pearson CE.

Biochemistry. 2013 Feb 5;52(5):773-85. doi: 10.1021/bi301369b. Epub 2013 Jan 22.

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