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Items: 1 to 20 of 134

1.

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.

Christodoulou MS, Zunino F, Zuco V, Borrelli S, Comi D, Fontana G, Martinelli M, Lorens JB, Evensen L, Sironi M, Pieraccini S, Dalla Via L, Gia OM, Passarella D.

ChemMedChem. 2012 Dec;7(12):2134-43. doi: 10.1002/cmdc.201200322. Epub 2012 Oct 19.

PMID:
23086693
2.

Synthesis and antitumor activity evaluation of a novel series of camptothecin analogs.

Lv J, Guo N, Wen SP, Teng YO, Ma MX, Yu P.

J Asian Nat Prod Res. 2013;15(8):867-74. doi: 10.1080/10286020.2013.804068. Epub 2013 Jun 25.

PMID:
23796391
3.

Synthesis of 9-(heteroarylmethylidene)amino derivatives of homocamptothecin with biological activities.

Guo W, Miao Z, Sheng C, Yao J, Liu W, Zhu L, Zhang Y, Cheng P, Dong G, Zhuang C, Zhang W.

Chem Biodivers. 2011 Jul;8(7):1266-73. doi: 10.1002/cbdv.201000271.

PMID:
21766447
4.

Synthesis and biological evaluation of novel homocamptothecins conjugating with dihydropyrimidine derivatives as potent topoisomerase I inhibitors.

Zhu L, Cheng P, Lei N, Yao J, Sheng C, Zhuang C, Guo W, Liu W, Zhang Y, Dong G, Wang S, Miao Z, Zhang W.

Arch Pharm (Weinheim). 2011 Nov;344(11):726-34. doi: 10.1002/ardp.201000402. Epub 2011 Sep 29.

PMID:
21956522
5.

Synthesis and biological evaluation of new camptothecin derivatives obtained by modification of position 20.

Riva E, Comi D, Borrelli S, Colombo F, Danieli B, Borlak J, Evensen L, Lorens JB, Fontana G, Gia OM, Via LD, Passarella D.

Bioorg Med Chem. 2010 Dec 15;18(24):8660-8. doi: 10.1016/j.bmc.2010.09.069. Epub 2010 Oct 7.

PMID:
21071230
6.

Semisynthesis, biological activity, and molecular modeling studies of C-ring-modified camptothecins.

Samorì C, Guerrini A, Varchi G, Fontana G, Bombardelli E, Tinelli S, Beretta GL, Basili S, Moro S, Zunino F, Battaglia A.

J Med Chem. 2009 Feb 26;52(4):1029-39. doi: 10.1021/jm801153y.

PMID:
19530720
7.

Synthesis and biological evaluation of new homocamptothecin analogs.

Luo Y, Yu S, Tong L, Huang Q, Lu W, Chen Y.

Eur J Med Chem. 2012 Aug;54:281-6. doi: 10.1016/j.ejmech.2012.05.002. Epub 2012 May 15.

PMID:
22647222
8.

Structure and properties of camptothecin derivatives, their protonated forms, and model interaction with the topoisomerase I-DNA complex.

Ivanova B, Spiteller M.

Biopolymers. 2012 Feb;97(2):134-44. doi: 10.1002/bip.21714. Epub 2011 Sep 6.

PMID:
21898362
9.
10.

Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells.

Su H, Zhang P, Cheetham AG, Koo JM, Lin R, Masood A, Schiapparelli P, Quiñones-Hinojosa A, Cui H.

Theranostics. 2016 Apr 28;6(7):1065-74. doi: 10.7150/thno.15420. eCollection 2016.

11.

Anticancer activity of new haloalkyl camptothecin esters against human cancer cell lines and human tumor xenografts grown in nude mice.

Cao Z, Mendoza J, Kozielski A, Liu X, Dejesus A, Wang Y, Zhan CG, Vardeman D, Giovanella B.

Anticancer Agents Med Chem. 2012 Sep;12(7):818-28.

PMID:
22583427
12.

A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity.

Deshmukh M, Chao P, Kutscher HL, Gao D, Sinko PJ.

J Med Chem. 2010 Feb 11;53(3):1038-47. doi: 10.1021/jm901029n.

13.

Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.

Liu W, Zhu L, Guo W, Zhuang C, Zhang Y, Sheng C, Cheng P, Yao J, Wang W, Dong G, Wang S, Miao Z, Zhang W.

Eur J Med Chem. 2011 Jun;46(6):2408-14. doi: 10.1016/j.ejmech.2011.03.024. Epub 2011 Mar 23.

PMID:
21463912
14.

Bioreduction activated prodrugs of camptothecin: molecular design, synthesis, activation mechanism and hypoxia selective cytotoxicity.

Zhang Z, Tanabe K, Hatta H, Nishimoto S.

Org Biomol Chem. 2005 May 21;3(10):1905-10. Epub 2005 Apr 14.

PMID:
15889173
15.

Synthesis and cytotoxic activity of new 9-substituted camptothecins.

Dallavalle S, Rocchetta DG, Musso L, Merlini L, Morini G, Penco S, Tinelli S, Beretta GL, Zunino F.

Bioorg Med Chem Lett. 2008 May 1;18(9):2781-7. doi: 10.1016/j.bmcl.2008.04.016. Epub 2008 Apr 10.

PMID:
18434153
16.

10-Boronic acid substituted camptothecin as prodrug of SN-38.

Wang L, Xie S, Ma L, Chen Y, Lu W.

Eur J Med Chem. 2016 Jun 30;116:84-89. doi: 10.1016/j.ejmech.2016.03.063. Epub 2016 Mar 24.

PMID:
27060760
17.

Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies.

Yoon KJ, Krull EJ, Morton CL, Bornmann WG, Lee RE, Potter PM, Danks MK.

Mol Cancer Ther. 2003 Nov;2(11):1171-81.

18.

Synthesis and activity of a folate peptide camptothecin prodrug.

Henne WA, Doorneweerd DD, Hilgenbrink AR, Kularatne SA, Low PS.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5350-5. Epub 2006 Aug 9.

PMID:
16901694
19.

Synthesis and activity of a folate targeted monodisperse PEG camptothecin conjugate.

Henne WA, Kularatne SA, Hakenjos J, Carron JD, Henne KL.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5810-3. doi: 10.1016/j.bmcl.2013.08.113. Epub 2013 Sep 7.

PMID:
24064501
20.

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

Fournier-Dit-Chabert J, Vinader V, Santos AR, Redondo-Horcajo M, Dreneau A, Basak R, Cosentino L, Marston G, Abdel-Rahman H, Loadman PM, Shnyder SD, Díaz JF, Barasoain I, Falconer RA, Pors K.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7693-6. doi: 10.1016/j.bmcl.2012.09.104. Epub 2012 Oct 10.

PMID:
23103097

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