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Items: 1 to 20 of 100

1.

Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival.

Véret J, Coant N, Gorshkova IA, Giussani P, Fradet M, Riccitelli E, Skobeleva A, Goya J, Kassis N, Natarajan V, Portha B, Berdyshev EV, Le Stunff H.

Biochim Biophys Acta. 2013 Feb;1831(2):251-62. doi: 10.1016/j.bbalip.2012.10.003. Epub 2012 Oct 17.

PMID:
23085009
2.
3.

FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.

Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG, Natarajan V.

J Biol Chem. 2009 Feb 27;284(9):5467-77. doi: 10.1074/jbc.M805186200. Epub 2009 Jan 1.

4.

Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.

Véret J, Coant N, Berdyshev EV, Skobeleva A, Therville N, Bailbé D, Gorshkova I, Natarajan V, Portha B, Le Stunff H.

Biochem J. 2011 Aug 15;438(1):177-89. doi: 10.1042/BJ20101386.

PMID:
21592087
5.

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

Maceyka M, Sankala H, Hait NC, Le Stunff H, Liu H, Toman R, Collier C, Zhang M, Satin LS, Merrill AH Jr, Milstien S, Spiegel S.

J Biol Chem. 2005 Nov 4;280(44):37118-29. Epub 2005 Aug 23.

6.

Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1α Protein Expression.

Qi Y, Wang W, Chen J, Dai L, Kaczorowski D, Gao X, Xia P.

J Biol Chem. 2015 Sep 18;290(38):23282-90. doi: 10.1074/jbc.M115.677542. Epub 2015 Aug 3.

7.

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, Pettus B, Hannun YA, Obeid L, Trojanowska M.

J Biol Chem. 2004 Dec 24;279(52):53994-4001. Epub 2004 Oct 12.

8.

Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells.

Jung IR, Choi SE, Jung JG, Lee SA, Han SJ, Kim HJ, Kim DJ, Lee KW, Kang Y.

Mol Cell Endocrinol. 2015 May 15;407:74-84. doi: 10.1016/j.mce.2015.03.007. Epub 2015 Mar 14.

PMID:
25779532
9.

Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis.

Wu J, Sun P, Zhang X, Liu H, Jiang H, Zhu W, Wang H.

J Cell Biochem. 2012 Apr;113(4):1152-8. doi: 10.1002/jcb.23450. Erratum in: J Cell Biochem. 2013 May;114(5):1216.

PMID:
22275065
10.

Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase.

Suzuki H, Riley RT, Sharma RP.

Toxicology. 2007 Jan 5;229(1-2):42-53. Epub 2006 Sep 29.

11.

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.

Matula K, Collie-Duguid E, Murray G, Parikh K, Grabsch H, Tan P, Lalwani S, Garau R, Ong Y, Bain G, Smith AD, Urquhart G, Bielawski J, Finnegan M, Petty R.

BMC Cancer. 2015 Oct 22;15:762. doi: 10.1186/s12885-015-1718-7.

12.

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.

Kharroubi I, Ladrière L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL.

Endocrinology. 2004 Nov;145(11):5087-96. Epub 2004 Aug 5.

PMID:
15297438
13.

Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.

Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C, Obeid LM.

J Biol Chem. 2003 Sep 5;278(36):34541-7. Epub 2003 Jun 18.

14.
15.

Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells.

Sargsyan E, Bergsten P.

Lipids Health Dis. 2011 Jul 11;10:115. doi: 10.1186/1476-511X-10-115.

16.

Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis.

Karimian G, Buist-Homan M, Schmidt M, Tietge UJ, de Boer JF, Klappe K, Kok JW, Combettes L, Tordjmann T, Faber KN, Moshage H.

Biochim Biophys Acta. 2013 Dec;1832(12):1922-9. doi: 10.1016/j.bbadis.2013.06.011. Epub 2013 Jun 28.

17.

Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest.

Gorshkova IA, Wang H, Orbelyan GA, Goya J, Natarajan V, Beiser DG, Vanden Hoek TL, Berdyshev EV.

Life Sci. 2013 Sep 17;93(9-11):359-66. doi: 10.1016/j.lfs.2013.07.017. Epub 2013 Jul 24.

PMID:
23892195
18.

Differential impact of acute and chronic lipotoxicity on gene expression in INS-1 cells.

Xiao J, Gregersen S, Pedersen SB, Hermansen K.

Metabolism. 2002 Feb;51(2):155-62.

PMID:
11833041
19.

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. doi: 10.1152/ajpendo.00478.2007. Epub 2008 Jan 15.

20.

Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells.

Böhm A, Flößer A, Ermler S, Fender AC, Lüth A, Kleuser B, Schrör K, Rauch BH.

Cardiovasc Res. 2013 Aug 1;99(3):505-13. doi: 10.1093/cvr/cvt112. Epub 2013 May 7.

PMID:
23658376

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