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Items: 1 to 20 of 105

1.

Long-timescale molecular dynamics simulations elucidate the dynamics and kinetics of exposure of the hydrophobic patch in troponin C.

Lindert S, Kekenes-Huskey PM, McCammon JA.

Biophys J. 2012 Oct 17;103(8):1784-9. doi: 10.1016/j.bpj.2012.08.058. Epub 2012 Oct 16.

2.

Photocrosslinking of benzophenone-labeled single cysteine troponin I mutants to other thin filament proteins.

Luo Y, Wu JL, Li B, Langsetmo K, Gergely J, Tao T.

J Mol Biol. 2000 Feb 25;296(3):899-910.

PMID:
10677290
3.

Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study.

Lindert S, Kekenes-Huskey PM, Huber G, Pierce L, McCammon JA.

J Phys Chem B. 2012 Jul 26;116(29):8449-59. doi: 10.1021/jp212173f. Epub 2012 Feb 14.

4.

Molecular basis of calcium-sensitizing and desensitizing mutations of the human cardiac troponin C regulatory domain: a multi-scale simulation study.

Kekenes-Huskey PM, Lindert S, McCammon JA.

PLoS Comput Biol. 2012;8(11):e1002777. doi: 10.1371/journal.pcbi.1002777. Epub 2012 Nov 29.

5.
6.

Calcium- and magnesium-dependent interactions between the C-terminus of troponin I and the N-terminal, regulatory domain of troponin C.

Digel J, Abugo O, Kobayashi T, Gryczynski Z, Lakowicz JR, Collins JH.

Arch Biochem Biophys. 2001 Mar 15;387(2):243-9.

PMID:
11370847
7.

Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C.

Cordina NM, Liew CK, Gell DA, Fajer PG, Mackay JP, Brown LJ.

Biochemistry. 2013 Mar 19;52(11):1950-62. doi: 10.1021/bi4000172. Epub 2013 Mar 6.

PMID:
23425245
8.

Structural and functional studies on Troponin I and Troponin C interactions.

Ngai SM, Pearlstone JR, Farah CS, Reinach FC, Smillie LB, Hodges RS.

J Cell Biochem. 2001 Jun 26-Jul 25;83(1):33-46. Erratum in: J Cell Biochem 2002;84(4):847.

PMID:
11500952
10.

Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations.

Stevens CM, Rayani K, Singh G, Lotfalisalmasi B, Tieleman DP, Tibbits GF.

J Biol Chem. 2017 Jul 14;292(28):11915-11926. doi: 10.1074/jbc.M116.770776. Epub 2017 May 22.

PMID:
28533433
11.

Involvement of conserved, acidic residues in the N-terminal domain of troponin C in calcium-dependent regulation.

Kobayashi T, Zhao X, Wade R, Collins JH.

Biochemistry. 1999 Apr 27;38(17):5386-91.

PMID:
10220325
12.

Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC.

Stevens CM, Rayani K, Genge CE, Singh G, Liang B, Roller JM, Li C, Li AY, Tieleman DP, van Petegem F, Tibbits GF.

Biophys J. 2016 Jul 12;111(1):38-49. doi: 10.1016/j.bpj.2016.05.029.

13.

Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems.

Tikunova SB, Liu B, Swindle N, Little SC, Gomes AV, Swartz DR, Davis JP.

Biochemistry. 2010 Mar 9;49(9):1975-84. doi: 10.1021/bi901867s.

16.

A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility.

Lim CC, Yang H, Yang M, Wang CK, Shi J, Berg EA, Pimentel DR, Gwathmey JK, Hajjar RJ, Helmes M, Costello CE, Huo S, Liao R.

Biophys J. 2008 May 1;94(9):3577-89. doi: 10.1529/biophysj.107.112896. Epub 2008 Jan 22.

17.

Ca(2+) and Mg(2+) binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament.

Braga CA, Pinto JR, Valente AP, Silva JL, Sorenson MM, Foguel D, Suarez MC.

Int J Biochem Cell Biol. 2006 Jan;38(1):110-22. Epub 2005 Sep 9.

PMID:
16183325
18.

Effect of Ca2+ binding properties of troponin C on rate of skeletal muscle force redevelopment.

Lee RS, Tikunova SB, Kline KP, Zot HG, Hasbun JE, Minh NV, Swartz DR, Rall JA, Davis JP.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C1091-9. doi: 10.1152/ajpcell.00491.2009. Epub 2010 Aug 11.

19.

Structures of four Ca2+-bound troponin C at 2.0 A resolution: further insights into the Ca2+-switch in the calmodulin superfamily.

Houdusse A, Love ML, Dominguez R, Grabarek Z, Cohen C.

Structure. 1997 Dec 15;5(12):1695-711.

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