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Items: 1 to 20 of 244

1.

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.

Goranovič D, Blažič M, Magdevska V, Horvat J, Kuščer E, Polak T, Santos-Aberturas J, Martínez-Castro M, Barreiro C, Mrak P, Kopitar G, Kosec G, Fujs S, Martín JF, Petković H.

BMC Microbiol. 2012 Oct 19;12:238. doi: 10.1186/1471-2180-12-238.

2.

Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.

Ordóñez-Robles M, Rodríguez-García A, Martín JF.

Appl Microbiol Biotechnol. 2016 Sep;100(18):8091-103. doi: 10.1007/s00253-016-7696-0. Epub 2016 Jun 29.

PMID:
27357227
3.

Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.

Mo S, Yoo YJ, Ban YH, Lee SK, Kim E, Suh JW, Yoon YJ.

Appl Environ Microbiol. 2012 Apr;78(7):2249-55. doi: 10.1128/AEM.06766-11. Epub 2012 Jan 20.

4.

FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.

Zhang XS, Luo HD, Tao Y, Wang YY, Jiang XH, Jiang H, Li YQ.

J Ind Microbiol Biotechnol. 2016 Dec;43(12):1693-1703. Epub 2016 Oct 18.

PMID:
27757551
5.

Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).

Barreiro C, Prieto C, Sola-Landa A, Solera E, Martínez-Castro M, Pérez-Redondo R, García-Estrada C, Aparicio JF, Fernández-Martínez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodríguez-García A, Tauch A, Martín JF.

J Bacteriol. 2012 Jul;194(14):3756-7. doi: 10.1128/JB.00692-12.

6.
7.

Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.

Jones AC, Gust B, Kulik A, Heide L, Buttner MJ, Bibb MJ.

PLoS One. 2013 Jul 11;8(7):e69319. doi: 10.1371/journal.pone.0069319. Print 2013.

8.

Novel chemobiosynthetic approach for exclusive production of FK506.

Kosec G, Goranovič D, Mrak P, Fujs S, Kuščer E, Horvat J, Kopitar G, Petković H.

Metab Eng. 2012 Jan;14(1):39-46. doi: 10.1016/j.ymben.2011.11.003. Epub 2011 Nov 12.

PMID:
22100790
9.

Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement.

Huang D, Li S, Xia M, Wen J, Jia X.

Microb Cell Fact. 2013 May 24;12:52. doi: 10.1186/1475-2859-12-52.

10.

The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control.

Salehi-Najafabadi Z, Barreiro C, Rodríguez-García A, Cruz A, López GE, Martín JF.

Appl Microbiol Biotechnol. 2014 Jun;98(11):4919-36. doi: 10.1007/s00253-014-5595-9. Epub 2014 Feb 22.

PMID:
24562179
11.

Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.

Blažič M, Kosec G, Baebler Š, Gruden K, Petković H.

Microb Cell Fact. 2015 Oct 14;14:164. doi: 10.1186/s12934-015-0352-z.

12.

Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies.

Du W, Huang D, Xia M, Wen J, Huang M.

J Ind Microbiol Biotechnol. 2014 Jul;41(7):1131-43. doi: 10.1007/s10295-014-1450-3. Epub 2014 May 1.

PMID:
24788378
13.

Origin of the allyl group in FK506 biosynthesis.

Goranovic D, Kosec G, Mrak P, Fujs S, Horvat J, Kuscer E, Kopitar G, Petkovic H.

J Biol Chem. 2010 May 7;285(19):14292-300. doi: 10.1074/jbc.M109.059600. Epub 2010 Mar 1.

14.

Improvement of Wuyiencin biosynthesis in Streptomyces wuyiensis CK-15 by identification of a key regulator, WysR.

Liu Y, Ryu H, Ge B, Pan G, Sun L, Park K, Zhang K.

J Microbiol Biotechnol. 2014 Dec 28;24(12):1644-53.

15.

Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer 'Streptomyces tsukubaensis'.

Martínez-Castro M, Salehi-Najafabadi Z, Romero F, Pérez-Sanchiz R, Fernández-Chimeno RI, Martín JF, Barreiro C.

Appl Microbiol Biotechnol. 2013 Mar;97(5):2139-52. doi: 10.1007/s00253-012-4364-x. Epub 2012 Sep 20.

PMID:
22990582
16.

Identification and characterization of wblA-dependent tmcT regulation during tautomycetin biosynthesis in Streptomyces sp. CK4412.

Nah JH, Park SH, Yoon HM, Choi SS, Lee CH, Kim ES.

Biotechnol Adv. 2012 Jan-Feb;30(1):202-9. doi: 10.1016/j.biotechadv.2011.05.004. Epub 2011 May 20. Erratum in: Biotechnol Adv. 2012 Nov;30(6):1750.

PMID:
21624452
17.

Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.

Xia M, Huang D, Li S, Wen J, Jia X, Chen Y.

Biotechnol Bioeng. 2013 Oct;110(10):2717-30. doi: 10.1002/bit.24941. Epub 2013 May 16.

PMID:
23682004
18.

Overexpression of the putative extracytoplasmic function sigma (σ) factor FujE enhances FK506 production in Streptomyces sp. strain KCCM 11116P.

Lee SK, Yang SH, Kang CM, Mo S, Suh JW.

Can J Microbiol. 2014 Jun;60(6):363-9. doi: 10.1139/cjm-2014-0166. Epub 2014 Apr 22.

PMID:
24869633
19.

Trends in the biosynthesis and production of the immunosuppressant tacrolimus (FK506).

Barreiro C, Martínez-Castro M.

Appl Microbiol Biotechnol. 2014 Jan;98(2):497-507. doi: 10.1007/s00253-013-5362-3. Epub 2013 Nov 24. Review.

PMID:
24272367
20.

dRNA-seq transcriptional profiling of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis NRRL18488 and general analysis of the transcriptome.

Bauer JS, Fillinger S, Förstner K, Herbig A, Jones AC, Flinspach K, Sharma C, Gross H, Nieselt K, Apel AK.

RNA Biol. 2017 Jun 30:1-10. doi: 10.1080/15476286.2017.1341020. [Epub ahead of print]

PMID:
28665778

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