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Systematic investigation of changes in oxidized cerebral cytochrome c oxidase concentration during frontal lobe activation in healthy adults.

Kolyva C, Tachtsidis I, Ghosh A, Moroz T, Cooper CE, Smith M, Elwell CE.

Biomed Opt Express. 2012 Oct 1;3(10):2550-66. doi: 10.1364/BOE.3.002550. Epub 2012 Sep 14.


Spatial Distribution of Changes in Oxidised Cytochrome C Oxidase During Visual Stimulation Using Broadband Near Infrared Spectroscopy Imaging.

Phan P, Highton D, Brigadoi S, Tachtsidis I, Smith M, Elwell CE.

Adv Exp Med Biol. 2016;923:195-201. doi: 10.1007/978-3-319-38810-6_26.


Cytochrome c oxidase response to changes in cerebral oxygen delivery in the adult brain shows higher brain-specificity than haemoglobin.

Kolyva C, Ghosh A, Tachtsidis I, Highton D, Cooper CE, Smith M, Elwell CE.

Neuroimage. 2014 Jan 15;85 Pt 1:234-44. doi: 10.1016/j.neuroimage.2013.05.070. Epub 2013 May 23.


Dependence on NIRS source-detector spacing of cytochrome c oxidase response to hypoxia and hypercapnia in the adult brain.

Kolyva C, Ghosh A, Tachtsidis I, Highton D, Smith M, Elwell CE.

Adv Exp Med Biol. 2013;789:353-359. doi: 10.1007/978-1-4614-7411-1_47.


Functional NIRS Measurement of Cytochrome-C-Oxidase Demonstrates a More Brain-Specific Marker of Frontal Lobe Activation Compared to the Haemoglobins.

de Roever I, Bale G, Cooper RJ, Tachtsidis I.

Adv Exp Med Biol. 2017;977:141-147. doi: 10.1007/978-3-319-55231-6_19.


Brain mitochondrial oxidative metabolism during and after cerebral hypoxia-ischemia studied by simultaneous phosphorus magnetic-resonance and broadband near-infrared spectroscopy.

Bainbridge A, Tachtsidis I, Faulkner SD, Price D, Zhu T, Baer E, Broad KD, Thomas DL, Cady EB, Robertson NJ, Golay X.

Neuroimage. 2014 Nov 15;102 Pt 1:173-83. doi: 10.1016/j.neuroimage.2013.08.016. Epub 2013 Aug 17. Review.


A new broadband near-infrared spectroscopy system for in-vivo measurements of cerebral cytochrome-c-oxidase changes in neonatal brain injury.

Bale G, Mitra S, Meek J, Robertson N, Tachtsidis I.

Biomed Opt Express. 2014 Sep 5;5(10):3450-66. doi: 10.1364/BOE.5.003450. eCollection 2014 Oct 1.


Multi-channel multi-distance broadband near-infrared spectroscopy system to measure the spatial response of cellular oxygen metabolism and tissue oxygenation.

Phan P, Highton D, Lai J, Smith M, Elwell C, Tachtsidis I.

Biomed Opt Express. 2016 Oct 5;7(11):4424-4440. eCollection 2016 Nov 1.


Interrelationship Between Broadband NIRS Measurements of Cerebral Cytochrome C Oxidase and Systemic Changes Indicates Injury Severity in Neonatal Encephalopathy.

Bale G, Mitra S, de Roever I, Chan M, Caicedo-Dorado A, Meek J, Robertson N, Tachtsidis I.

Adv Exp Med Biol. 2016;923:181-186. doi: 10.1007/978-3-319-38810-6_24.


Measurement of frontal lobe functional activation and related systemic effects: a near-infrared spectroscopy investigation.

Tachtsidis I, Leung TS, Devoto L, Delpy DT, Elwell CE.

Adv Exp Med Biol. 2008;614:397-403. doi: 10.1007/978-0-387-74911-2_44.


Relationship between brain tissue haemodynamics, oxygenation and metabolism in the healthy human adult brain during hyperoxia and hypercapnea.

Tachtsidis I, Tisdall MM, Leung TS, Pritchard C, Cooper CE, Smith M, Elwell CE.

Adv Exp Med Biol. 2009;645:315-20. doi: 10.1007/978-0-387-85998-9_47.


Changes in the attenuation of near infrared spectra by the healthy adult brain during hypoxaemia cannot be accounted for solely by changes in the concentrations of oxy- and deoxy-haemoglobin.

Tisdall MM, Tachtsidis I, Leung TS, Elwell CE, Smith M.

Adv Exp Med Biol. 2008;614:217-25. doi: 10.1007/978-0-387-74911-2_25.


Changes in Cerebral Oxidative Metabolism during Neonatal Seizures Following Hypoxic-Ischemic Brain Injury.

Mitra S, Bale G, Mathieson S, Uria-Avellanal C, Meek J, Tachtsidis I, Robertson NJ.

Front Pediatr. 2016 Aug 10;4:83. doi: 10.3389/fped.2016.00083. eCollection 2016.


Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data.

Brigadoi S, Phan P, Highton D, Powell S, Cooper RJ, Hebden J, Smith M, Tachtsidis I, Elwell CE, Gibson AP.

Neurophotonics. 2017 Apr;4(2):021105. doi: 10.1117/1.NPh.4.2.021105. Epub 2017 May 24.


Non-invasive measurement of a metabolic marker of infant brain function.

Siddiqui MF, Lloyd-Fox S, Kaynezhad P, Tachtsidis I, Johnson MH, Elwell CE.

Sci Rep. 2017 May 2;7(1):1330. doi: 10.1038/s41598-017-01394-z.


Analysis of the changes in the oxidation of brain tissue cytochrome-c-oxidase in traumatic brain injury patients during hypercapnoea: a broadband NIRS study.

Tachtsidis I, Tisdall MM, Pritchard C, Leung TS, Ghosh A, Elwell CE, Smith M.

Adv Exp Med Biol. 2011;701:9-14. doi: 10.1007/978-1-4419-7756-4_2.


Evaluation of Haemoglobin and Cytochrome Responses During Forearm Ischaemia Using Multi-wavelength Time Domain NIRS.

Lange F, Dunne L, Tachtsidis I.

Adv Exp Med Biol. 2017;977:67-72. doi: 10.1007/978-3-319-55231-6_10.


Investigation of in vivo measurement of cerebral cytochrome-c-oxidase redox changes using near-infrared spectroscopy in patients with orthostatic hypotension.

Tachtsidis I, Tisdall M, Leung TS, Cooper CE, Delpy DT, Smith M, Elwell CE.

Physiol Meas. 2007 Feb;28(2):199-211. Epub 2006 Dec 19.


Bicuculline-induced seizures: a challenge for optical and biochemical modeling of the cytochrome oxidase CuA NIRS signal.

Cooper CE, Cope M, Elwell CE, Delpy DT.

Adv Exp Med Biol. 2009;645:129-34. doi: 10.1007/978-0-387-85998-9_20.


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