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Items: 1 to 20 of 85

1.

A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.

Voigt T, Gerding-Reimers C, Ngoc Tran TT, Bergmann S, Lachance H, Schölermann B, Brockmeyer A, Janning P, Ziegler S, Waldmann H.

Angew Chem Int Ed Engl. 2013 Jan 2;52(1):410-4. doi: 10.1002/anie.201205728. Epub 2012 Oct 18.

PMID:
23080551
2.

Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization.

Zimmermann TJ, Roy S, Martinez NE, Ziegler S, Hedberg C, Waldmann H.

Chembiochem. 2013 Feb 11;14(3):295-300. doi: 10.1002/cbic.201200711. Epub 2013 Jan 31.

PMID:
23364933
3.

Novel 2-substituted quinolin-4-yl-benzenesulfonate derivatives: synthesis, antiproliferative activity, and inhibition of cellular tubulin polymerization.

Kakadiya R, Wu YC, Dong H, Kuo HH, Yih LH, Chou TC, Su TL.

ChemMedChem. 2011 Jun 6;6(6):1119-29. doi: 10.1002/cmdc.201100121. Epub 2011 May 3.

PMID:
21542133
4.

Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.

Aneja R, Vangapandu SN, Lopus M, Viswesarappa VG, Dhiman N, Verma A, Chandra R, Panda D, Joshi HC.

Biochem Pharmacol. 2006 Aug 14;72(4):415-26. Epub 2006 May 10.

PMID:
16780803
5.

UA62784 Is a cytotoxic inhibitor of microtubules, not CENP-E.

Tcherniuk S, Deshayes S, Sarli V, Divita G, Abrieu A.

Chem Biol. 2011 May 27;18(5):631-41. doi: 10.1016/j.chembiol.2011.03.006.

6.
7.

[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.

Mahboobi S, Sellmer A, Höcher H, Eichhorn E, Bär T, Schmidt M, Maier T, Stadlwieser JF, Beckers TL.

J Med Chem. 2006 Sep 21;49(19):5769-76.

PMID:
16970401
8.

Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents.

Qian Y, Zhang HJ, Lv PC, Zhu HL.

Bioorg Med Chem. 2010 Dec 1;18(23):8218-25. doi: 10.1016/j.bmc.2010.10.008. Epub 2010 Oct 29.

PMID:
21036623
9.

[Progress in the study of tubulin inhibitors].

Shang H, Pan L, Yang S, Chen H, Cheng MS.

Yao Xue Xue Bao. 2010 Sep;45(9):1078-88. Review. Chinese.

PMID:
21351562
10.

Increased cellular apoptosis susceptibility (CSE1L/CAS) protein expression promotes protrusion extension and enhances migration of MCF-7 breast cancer cells.

Tai CJ, Shen SC, Lee WR, Liao CF, Deng WP, Chiou HY, Hsieh CI, Tung JN, Chen CS, Chiou JF, Li LT, Lin CY, Hsu CH, Jiang MC.

Exp Cell Res. 2010 Oct 15;316(17):2969-81. doi: 10.1016/j.yexcr.2010.07.019. Epub 2010 Aug 3.

PMID:
20688056
11.

Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents.

Qian Y, Ma GY, Yang Y, Cheng K, Zheng QZ, Mao WJ, Shi L, Zhao J, Zhu HL.

Bioorg Med Chem. 2010 Jun 15;18(12):4310-6. doi: 10.1016/j.bmc.2010.04.091. Epub 2010 May 20.

PMID:
20493717
12.

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.

Bioorg Med Chem. 2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.

PMID:
23022053
13.

Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents.

Jiang J, Sun B, Wang YY, Cui M, Zhang L, Cui CZ, Wang YF, Liu XG, Lou HX.

Bioorg Med Chem. 2012 Apr 1;20(7):2382-91. doi: 10.1016/j.bmc.2012.02.004. Epub 2012 Feb 9.

PMID:
22365913
14.

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents.

Abuhaie CM, Bîcu E, Rigo B, Gautret P, Belei D, Farce A, Dubois J, Ghinet A.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):147-52. doi: 10.1016/j.bmcl.2012.10.135. Epub 2012 Nov 8.

PMID:
23200248
15.

Recent advances in the synthesis of tubulysins.

Xiangming X, Friestad GK, Lei Y.

Mini Rev Med Chem. 2013 Oct;13(11):1572-8. Review.

PMID:
23746060
16.

Podoverine A--a novel microtubule destabilizing natural product from the Podophyllum species.

Tran TT, Gerding-Reimers C, Schölermann B, Stanitzki B, Henkel T, Waldmann H, Ziegler S.

Bioorg Med Chem. 2014 Sep 15;22(18):5110-6. doi: 10.1016/j.bmc.2014.01.039. Epub 2014 Feb 1.

PMID:
24530033
17.

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin.

Vendrell-Navarro G, Rúa F, Bujons J, Brockmeyer A, Janning P, Ziegler S, Messeguer A, Waldmann H.

Chembiochem. 2015 Jul 27;16(11):1580-7. doi: 10.1002/cbic.201500169. Epub 2015 Jun 17.

PMID:
26010161
18.

Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents.

Kim ND, Park ES, Kim YH, Moon SK, Lee SS, Ahn SK, Yu DY, No KT, Kim KH.

Bioorg Med Chem. 2010 Oct 1;18(19):7092-100. doi: 10.1016/j.bmc.2010.07.072. Epub 2010 Aug 6.

PMID:
20810285
19.

Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.

Bennani YL, Gu W, Canales A, Díaz FJ, Eustace BK, Hoover RR, Jiménez-Barbero J, Nezami A, Wang T.

J Med Chem. 2012 Mar 8;55(5):1920-5. doi: 10.1021/jm200848t. Epub 2012 Feb 27.

PMID:
22320354
20.

Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin.

Bhattacharyya B, Panda D, Gupta S, Banerjee M.

Med Res Rev. 2008 Jan;28(1):155-83. Review.

PMID:
17464966

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